{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:56:43Z","timestamp":1793386603015,"version":"4.5.0"},"reference-count":85,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T00:00:00Z","timestamp":1697155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1196261"],"award-info":[{"award-number":["1196261"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Quetiapine is an antipsychotic medication indicated for schizophrenia and bipolar disorder. However, quetiapine also has hypnotic properties and as such is increasingly being prescribed at low doses \u2018off\u2010label\u2019 in people with insomnia symptoms. Pharmacologically, in addition to its dopaminergic properties, quetiapine also modulates multiple other transmitter systems involved in sleep\/wake modulation and potentially breathing. However, very little is known about the impact of quetiapine on obstructive sleep apnoea (OSA), OSA endotypes including chemosensitivity, and control of breathing. Given that many people with insomnia also have undiagnosed OSA, it is important to understand the effects of quetiapine on OSA and its mechanisms. Accordingly, this concise review covers the existing knowledge on the effects of quetiapine on sleep and breathing. Further, we highlight the pharmacodynamics of quetiapine and its potential to alter key OSA endotypes to provide potential mechanistic insight. Finally, an agenda for future research priorities is proposed to fill the current key knowledge gaps.<\/jats:p>","DOI":"10.1111\/jsr.14051","type":"journal-article","created":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T03:10:00Z","timestamp":1697253000000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Effects of the antipsychotic quetiapine on sleep and breathing: a review of clinical findings and potential mechanisms"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9993-0576","authenticated-orcid":false,"given":"Cricket","family":"Fauska","sequence":"first","affiliation":[{"name":"Adelaide Institute for Sleep Health\/Flinders Health and Medical Research Institute Sleep Health, College of Medicine and Public Health Flinders University  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6931-2913","authenticated-orcid":false,"given":"Tarun","family":"Bastiampillai","sequence":"additional","affiliation":[{"name":"Discipline of Psychiatry, College of Medicine and Public Health Flinders University  Adelaide South Australia Australia"},{"name":"Southern Adelaide Local Health Network Flinders Medical Centre  Adelaide South Australia Australia"},{"name":"Department of Psychiatry Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7572-0796","authenticated-orcid":false,"given":"Robert J.","family":"Adams","sequence":"additional","affiliation":[{"name":"Adelaide Institute for Sleep Health\/Flinders Health and Medical Research Institute Sleep Health, College of Medicine and Public Health Flinders University  Adelaide South Australia Australia"},{"name":"Respiratory, Sleep and Ventilation Service Southern Adelaide Local Health Network  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6818-6065","authenticated-orcid":false,"given":"Gary","family":"Wittert","sequence":"additional","affiliation":[{"name":"University of Adelaide  Adelaide South Australia Australia"},{"name":"Freemasons Centre for Male Health and Wellbeing, South Australian Health and Medical Research Institute University of Adelaide  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3503-2363","authenticated-orcid":false,"given":"Danny J.","family":"Eckert","sequence":"additional","affiliation":[{"name":"Adelaide Institute for Sleep Health\/Flinders Health and Medical Research Institute Sleep Health, College of Medicine and Public Health Flinders University  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3302-5995","authenticated-orcid":false,"given":"Kelly A.","family":"Loffler","sequence":"additional","affiliation":[{"name":"Adelaide Institute for Sleep Health\/Flinders Health and Medical Research Institute Sleep Health, College of Medicine and Public Health Flinders University  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,13]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01074.2020"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.10256"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/AIA.0000000000000357"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13009"},{"key":"e_1_2_14_6_1","unstructured":"AstraZeneca. (2020).Australian Product Information Seroquel. Retrieved fromhttps:\/\/www.ebs.tga.gov.au\/ebs\/picmi\/picmirepository.nsf\/pdf?OpenAgent&id=CP-2020-PI-02417-1&d=20211103172310101"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbres.2021.12.013"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.5561"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2020.1713091"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2021.11.023"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-021-01689-8"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.308097"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.18773\/austprescr.2015.032"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00213.2015"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2022.114680"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2021.101492"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612821666150619092903"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/jcp.0000000000000130"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2014.10.018"},{"key":"e_1_2_14_20_1","unstructured":"ClinCalc.com. (2023).Quetiapine Drug Usage Statistics United States 2013\u20132020. Retrieved fromhttps:\/\/clincalc.com\/DrugStats\/Drugs\/Quetiapine"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-003-1759-5"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13346"},{"key":"e_1_2_14_23_1","unstructured":"Drug Utilisation Sub\u2010Committee A. G. D. o. H. (2013).DUSC review on the utilisation of antipsychotics \u2013 August 2013. Public Summary Document. Retrieved fromhttps:\/\/www.pbs.gov.au\/industry\/listing\/elements\/pbac-meetings\/psd\/2013-08\/antipsychotics-psd-08-2013.pdf"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2016.12.003"},{"key":"e_1_2_14_25_1","volume-title":"Kryger's principles and practice of sleep medicine","author":"Eckert D. J.","year":"2021"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.3596"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs20100588"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201303-0448oc"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-016-0352-5"},{"key":"e_1_2_14_30_1","unstructured":"FDA. (2020).Highlights of Prescribing Information Seroquel XR (Quetiapine) extended\u2010release tablets for oral use. Retrieved fromhttps:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2020\/022047Orig1s042lbl.pdf"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200202-107OC"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.3109\/00207450903222758"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2016.05.005"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.2147\/ndt.s12433"},{"issue":"3","key":"e_1_2_14_35_1","first-page":"487","article-title":"Gender issues in obstructive sleep apnea","volume":"94","author":"Geer J. H.","year":"2021","journal-title":"The Yale Journal of Biology and Medicine"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-017-2281-8"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0256-2021"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12875-021-01510-z"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/00050067.2022.2089544"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(15)00043-0"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/wps.21010"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301646"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130100761"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.6506"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881116681399"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-017-1537-y"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/yic.0000000000000124"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2017.11.029"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2018.03.002"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21155434"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.28419"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP281912"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2017.02.032"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13548"},{"key":"e_1_2_14_55_1","unstructured":"Mabbott V. Paul Storey P. B. D. &Commonwealth of Australia. (2016).Australian Statistics on Medicines 2015. Retrieved fromhttps:\/\/www.pbs.gov.au\/info\/statistics\/asm\/asm-2015"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.2165\/11632030-000000000-00000"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleepj\/zsx050.318"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.88a.20031"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2017.04.008"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2022.11.024"},{"key":"e_1_2_14_61_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01788-2021"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws342"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.23.3015"},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2021.08.080"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.9778\/cmajo.20140009"},{"key":"e_1_2_14_66_1","volume-title":"Chronic insomnia disorder in Australia","author":"Reynolds A. C.","year":"2019"},{"key":"e_1_2_14_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12594"},{"key":"e_1_2_14_68_1","doi-asserted-by":"publisher","DOI":"10.1080\/15402002.2016.1266491"},{"key":"e_1_2_14_69_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201404-0783OC"},{"key":"e_1_2_14_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-015-4002-2"},{"key":"e_1_2_14_71_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.2182-17.2018"},{"key":"e_1_2_14_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2010.00890.x"},{"key":"e_1_2_14_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2021.101519"},{"key":"e_1_2_14_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2021.03.023"},{"key":"e_1_2_14_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.14009"},{"key":"e_1_2_14_76_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsac063"},{"key":"e_1_2_14_77_1","doi-asserted-by":"publisher","DOI":"10.5665\/SLEEP.1116"},{"key":"e_1_2_14_78_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201903-0692OC"},{"key":"e_1_2_14_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-007-0968-8"},{"key":"e_1_2_14_80_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j603"},{"key":"e_1_2_14_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-020-05663-0"},{"key":"e_1_2_14_82_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2109080"},{"key":"e_1_2_14_83_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.16.2013"},{"key":"e_1_2_14_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(83)90403-2"},{"key":"e_1_2_14_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2019.01.004"},{"key":"e_1_2_14_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleh.2022.07.004"}],"container-title":["Journal of Sleep Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsr.14051","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T05:02:40Z","timestamp":1715662960000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jsr.14051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,13]]},"references-count":85,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/jsr.14051"],"URL":"https:\/\/doi.org\/10.1111\/jsr.14051","archive":["Portico"],"relation":{},"ISSN":["0962-1105","1365-2869"],"issn-type":[{"value":"0962-1105","type":"print"},{"value":"1365-2869","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,13]]},"assertion":[{"value":"2023-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14051"}}