{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:14:07Z","timestamp":1787015647628,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:00:00Z","timestamp":1698105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515011127"],"award-info":[{"award-number":["2021A1515011127"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Dexmedetomidine (DEX) has been described as a safe sedative in clinical practice, but its effects on the pathophysiological traits of obstructive sleep apnea (OSA) are unclear. We estimated the effects of DEX sedation on the four key pathophysiological traits of OSA (pharyngeal collapsibility, dilator muscle function, arousal threshold, and loop gain) in adult patients with OSA by conducting a secondary analysis of a prospective diagnostic trial. Pathophysiological traits estimated from polysomnography and the respiratory parameters under natural sleep and DEX\u2010induced sleep were compared. Bivariate and multivariate linear regression analyses were used to estimate the relationship between pathophysiological traits and OSA severity for both sleep states. Adult patients with OSA had a significantly higher pharyngeal collapsibility (V\n                    <jats:sub>passive<\/jats:sub>\n                    : 44.9 [15.7 to 53.8] vs. 53.3 [34.2 to 66.3] %\n                    <jats:sub>eupnea<\/jats:sub>\n                    ,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), arousal threshold (178.5 [132.5 to 234.6] vs. 140.5 [123.2 to 192.3] %\n                    <jats:sub>eupnea<\/jats:sub>\n                    ,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), and loop gain (LG1: 0.74\u2009\u00b1\u20090.25 vs. 0.60\u2009\u00b1\u20090.17,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001; LGn: 0.52\u2009\u00b1\u20090.12 vs. 0.44\u2009\u00b1\u20090.08,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) during DEX\u2010induced sleep compared with natural sleep. There was no significant difference in dilator muscle function or PSG respiratory parameters between natural versus DEX\u2010induced sleep states. Bivariate regression analysis showed varying degrees of correlation between OSA traits and severity. Multiple regression analysis indicated that collapsibility was the strongest predictor of the apnea\u2013hypopnea index for both sleep states. Dexmedetomidine sedation in patients with OSA increased the pharyngeal collapsibility without impairing dilator muscle function, while elevating arousal threshold and increasing loop gain.\n                  <\/jats:p>","DOI":"10.1111\/jsr.14079","type":"journal-article","created":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T02:50:07Z","timestamp":1698202207000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Identifying the pathophysiological traits of obstructive sleep apnea during dexmedetomidine sedation"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7847-9858","authenticated-orcid":false,"given":"Chunbo","family":"Li","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology The First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Guangzhou Key Laboratory of Otorhinolaryngology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renqiang","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology The First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Guangzhou Key Laboratory of Otorhinolaryngology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingmei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology The First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Guangzhou Key Laboratory of Otorhinolaryngology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology The First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Guangzhou Key Laboratory of Otorhinolaryngology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology The First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Guangzhou Key Laboratory of Otorhinolaryngology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology The First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Guangzhou Key Laboratory of Otorhinolaryngology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology The First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Guangzhou Key Laboratory of Otorhinolaryngology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology The First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Guangzhou Key Laboratory of Otorhinolaryngology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wu","sequence":"additional","affiliation":[{"name":"Guangzhou Key Laboratory of Otorhinolaryngology  Guangzhou China"},{"name":"Department of Anesthesiology The First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou 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