{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T08:53:05Z","timestamp":1781340785255,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T00:00:00Z","timestamp":1699401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AARG\u201019\u2010618403"],"award-info":[{"award-number":["AARG\u201019\u2010618403"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002620","name":"Asian Center for Theological Studies and Missions, Asia United Theological University","doi-asserted-by":"publisher","award":["KL2TR002536"],"award-info":[{"award-number":["KL2TR002536"]}],"id":[{"id":"10.13039\/501100002620","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research","doi-asserted-by":"publisher","award":["P20 NR018081"],"award-info":[{"award-number":["P20 NR018081"]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Hippocampal atrophy is a prominent neurodegenerative feature of Alzheimer's disease and related dementias. Alterations in circadian rhythms can exacerbate cognitive aging and neurodegeneration. This study aimed to examine how dim light melatonin onset and melatonin levels are associated with hippocampal volume in cognitively healthy individuals. We studied data from 52 later\u2010life adults (mean age\u2009\u00b1\u2009SD\u2009=\u200970.0\u2009\u00b1\u20096.3\u2009years). T1\u2010weighted anatomical images from 3.0\u2009T magnetic resonance imaging data were collected and processed using the BRAINSTools toolbox. Dim light melatonin onset was used to assess circadian timing. The area under the curve was calculated to quantify melatonin concentration levels 6\u2009hr before bedtime, and 14\u2010day wrist actigraphy data were used to assess habitual bedtime. Multiple linear regression modelling with hippocampal volume as the dependent variable was used to analyse the data adjusting for age and sex. The average dim light melatonin onset was 19:45\u2005hours (SD\u2009=\u200984\u2009min), and area under the curve of melatonin levels 6\u2009hr before habitual bedtime was 38.4\u2009pg\u2005ml<jats:sup>\u22121<\/jats:sup>\u2009\u00d7\u2009hr (SD\u2009=\u200929.3). We found that later dim light melatonin onset time (<jats:italic>b<\/jats:italic>\u2009=\u20090.16, <jats:italic>p<\/jats:italic>\u2009=\u20090.005) and greater area under the curve of melatonin levels 6\u2009hr before habitual bedtime (<jats:italic>b<\/jats:italic>\u2009=\u20090.05, <jats:italic>p<\/jats:italic>\u2009=\u20090.046) were associated with greater adjusted hippocampal volume. The time between dim light melatonin onset and the midpoint of sleep timing was not associated with hippocampal volume. The findings suggest that earlier circadian timing (dim light melatonin onset) and reduced melatonin may be associated with reduced hippocampal volume in older adults. Future research will help researchers utilize circadian rhythm information to delay brain aging.<\/jats:p>","DOI":"10.1111\/jsr.14090","type":"journal-article","created":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T02:25:40Z","timestamp":1699496740000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Circadian timing, melatonin and hippocampal volume in later\u2010life adults"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4828-5143","authenticated-orcid":false,"given":"Chooza","family":"Moon","sequence":"first","affiliation":[{"name":"University of Iowa College of Nursing  Iowa Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin F.","family":"Hoth","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Iowa Roy J. and Lucille A. Carver College of Medicine  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yelena","family":"Perkhounkova","sequence":"additional","affiliation":[{"name":"University of Iowa College of Nursing  Iowa Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meina","family":"Zhang","sequence":"additional","affiliation":[{"name":"University of Iowa College of Nursing  Iowa Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihye","family":"Lee","sequence":"additional","affiliation":[{"name":"University of Iowa College of Nursing  Iowa Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Hein","sequence":"additional","affiliation":[{"name":"University of Iowa College of Nursing  Iowa Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Hopkins","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Iowa Roy J. and Lucille A. Carver College of Medicine  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Magnotta","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Iowa Roy J. and Lucille A. Carver College of Medicine  Iowa City Iowa USA"},{"name":"Department of Radiology University of Iowa Roy J. and Lucille A. Carver College of Medicine  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3816-8194","authenticated-orcid":false,"given":"Helen J.","family":"Burgess","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Sleep and Circadian Research Laboratory University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleepadvances\/zpab007"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibneur.2023.01.005"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.32598\/bcn.12.2.986.1"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00032.2011"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.08.014"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003055"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12384"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-36762-w"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsz033"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0071354"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2020.10.011"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-200331"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26617"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.2147\/nedt.1.2.155.61043"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.23397"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2018.04.013"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsad033"},{"issue":"4","key":"e_1_2_12_19_1","first-page":"168","article-title":"Sundowning and circadian rhythm disorders in dementia","volume":"106","author":"Klaffke S.","year":"2006","journal-title":"Acta Neurologica Belgica"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20200534"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/07420528.2011.597531"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2019.101904"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.4998"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/014662167700100306"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2010.00802.x"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2016.11.007"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10040615"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/crj.12909"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.3233\/JND-190397"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/074873049701200507"},{"key":"e_1_2_12_31_1","volume-title":"The calculus of observations: An introduction to numerical analysis","author":"Whittaker E. T.","year":"1967"},{"key":"e_1_2_12_32_1","unstructured":"World Health Organization. (2021).Global status report on the public health response to dementia.https:\/\/www.who.int\/publications-detail-redirect\/9789240033245"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1241224"}],"container-title":["Journal of Sleep Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsr.14090","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T05:17:37Z","timestamp":1729055857000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jsr.14090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,8]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1111\/jsr.14090"],"URL":"https:\/\/doi.org\/10.1111\/jsr.14090","archive":["Portico"],"relation":{},"ISSN":["0962-1105","1365-2869"],"issn-type":[{"value":"0962-1105","type":"print"},{"value":"1365-2869","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,8]]},"assertion":[{"value":"2023-08-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14090"}}