{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T20:30:34Z","timestamp":1778272234311,"version":"3.51.4"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T00:00:00Z","timestamp":1710720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020101","name":"ProMedica Senior Care","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020101","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Mitochondrial diseases are rare genetic disorders often accompanied by severe sleep disorders. We present the case of a 12\u2010year\u2010old boy diagnosed with a severe primary mitochondrial disease, exhibiting ataxia, spasticity, progressive external ophthalmoplegia, cardiomyopathy and severely disrupted sleep, but no cognitive impairment. Interestingly, his parents reported improved sleep during night train rides. Based on this observation, we installed a rocking bed in the patient's bedroom and performed different interventions, including immersive multimodal vestibular, kinesthetic and auditory stimuli, reminiscent of the sensory experiences encountered during train rides. Over a 5\u2010month period, we conducted four 2\u2010week nocturnal interventions, separated by 1\u2010week washout phases, to determine the subjectively best\u2010perceived stimulation parameters, followed by a final 4\u2010week intervention using the optimal parameters. We assessed sleep duration and quality using the Mini Sleep Questionnaire, monitored pulse rate changes and used videography to document nocturnal interactions between the patient and caregivers. Patient\u2010reported outcome measures, clinical examinations and personal outcomes of specific interests were used to document daytime sleepiness, restlessness, anxiety, fatigue, cognitive performance and physical posture. In the final 4\u2010week intervention, sleep duration increased by 25%, required caregiver interactions reduced by 75%, and caregiving time decreased by 40%. Subjective fatigue, assessed by the Checklist Individual Strength, decreased by 40%, falling below the threshold of severe fatigue. Our study suggests that rocking beds could provide a promising treatment regime for selected patients with persistent severe sleep disorders. Further research is required to validate these findings in larger patient populations with sleep disorders and other conditions.<\/jats:p>","DOI":"10.1111\/jsr.14153","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T04:06:42Z","timestamp":1710821202000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Nocturnal vestibular stimulation using a rocking bed improves a severe sleep disorder in a patient with mitochondrial disease"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9727-3491","authenticated-orcid":false,"given":"Alexander","family":"Breuss","sequence":"first","affiliation":[{"name":"ETH Zurich, Sensory\u2010Motor Systems Lab Institute of Robotics and Intelligent Systems  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Strasser","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Inselspital Bern University Hospital, University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Marc","family":"Nuoffer","sequence":"additional","affiliation":[{"name":"Division of Paediatric Endocrinology, Diabetology and Metabolism, Department of Paediatrics, and Institute of Clinical Chemistry, Inselspital Bern University Hospital, University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Klein","sequence":"additional","affiliation":[{"name":"Division of Neuropediatrics, Inselspital Bern University Hospital  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eveline","family":"Perret\u2010Hoign\u00e9","sequence":"additional","affiliation":[{"name":"Division of Neuropediatrics, Inselspital Bern University Hospital  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Felder","sequence":"additional","affiliation":[{"name":"Division of Neuropediatrics, Inselspital Bern University Hospital  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Stauffer","sequence":"additional","affiliation":[{"name":"Institute for Physiotherapy, Inselspital Bern University Hospital, University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3616-9038","authenticated-orcid":false,"given":"Peter","family":"Wolf","sequence":"additional","affiliation":[{"name":"ETH Zurich, Sensory\u2010Motor Systems Lab Institute of Robotics and Intelligent Systems  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1726-2950","authenticated-orcid":false,"given":"Robert","family":"Riener","sequence":"additional","affiliation":[{"name":"ETH Zurich, Sensory\u2010Motor Systems Lab Institute of Robotics and Intelligent Systems  Zurich Switzerland"},{"name":"Spinal Cord Injury Center University Hospital Balgrist  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1358-1759","authenticated-orcid":false,"given":"Matthias","family":"Gautschi","sequence":"additional","affiliation":[{"name":"Division of Paediatric Endocrinology, Diabetology and Metabolism, Department of Paediatrics, and Institute of Clinical Chemistry, Inselspital Bern University Hospital, University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/07420528.2014.901347"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2011.05.012"},{"key":"e_1_2_9_4_1","volume-title":"World Sleep Congress 2023","author":"Breuss A.","year":"2023"},{"key":"e_1_2_9_5_1","volume-title":"31. Jahrestagung Der Deutschen Gesellschaft F\u00fcr Schlafforschung Und Schlafmedizin e. V","author":"Breuss A.","year":"2023"},{"key":"e_1_2_9_6_1","volume-title":"Automation in medical engineering","author":"Breuss A.","year":"2023"},{"key":"e_1_2_9_7_1","volume-title":"Test of nonverbal intelligence: TONI\u20104","author":"Brown L.","year":"2010"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/S11910-021-01121-2\/TABLES\/1"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(89)90047-4"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11517-015-1423-3"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1078390317746726"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.5014\/AJOT.46.10.910"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0012162206001162"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.15761\/GMO.1000117"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.80"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NMD.2015.03.001"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1163\/22134808-00002495"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-13-808\/TABLES\/5"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/14.6.540"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00633"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1989.00520460115022"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00298.2002"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/JAMA.2014.16419"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01799112"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0150581"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-19880-3"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/J006v01n03_01"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1997.tb07414.x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NMD.2019.09.012"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1051\/medsci\/2019124"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2006.08.006"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/JSR.13051"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000011005"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.5664\/JCSM.4212"},{"key":"e_1_2_9_35_1","doi-asserted-by":"crossref","unstructured":"Russell D. J. Rosenbaum P. L. &Wright M.(Physiotherapist). GROSS MOTOR FUNCTION MEASURE (GMFM\u201066 & GMFM\u201088)\u2009: USER'S MANUAL. Published online 2021.","DOI":"10.1097\/PEP.0000000000000858"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2014\/10312.5298"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1378\/CHEST.14-0970"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1468-1331.2011.03496.X"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8227(96)01358-7"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-003-1422-8"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00421-006-0372-9\/METRICS"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18031"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.01446"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(94)90099-X"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dib.2019.104228"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/13.6.533"}],"container-title":["Journal of Sleep Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsr.14153","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:56:50Z","timestamp":1743555410000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jsr.14153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,18]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1111\/jsr.14153"],"URL":"https:\/\/doi.org\/10.1111\/jsr.14153","archive":["Portico"],"relation":{},"ISSN":["0962-1105","1365-2869"],"issn-type":[{"value":"0962-1105","type":"print"},{"value":"1365-2869","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,18]]},"assertion":[{"value":"2023-11-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14153"}}