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Most nocturnal gastro\u2010oesophageal reflux events occur during the awake cycle, and arousals precede most nocturnal gastro\u2010oesophageal reflux events, indicating that arousal from sleep predisposes to nocturnal gastro\u2010oesophageal reflux. This sheds light on the complex relationship between nocturnal gastro\u2010oesophageal reflux and sleep, and has implications for managing nocturnal gastro\u2010oesophageal reflux symptoms. The appearance of symptoms and the pathophysiology of nocturnal gastro\u2010oesophageal reflux are influenced by sleep hygiene, sleep disturbances and the misalignment of circadian rhythms. Nocturnal gastro\u2010oesophageal reflux and its related sleep disorders are prevalent and negatively impact the quality of life. There is conflicting evidence on whether nocturnal gastro\u2010oesophageal reflux and sleep disturbances are causally linked, and whether sleep disturbances drive nocturnal gastro\u2010oesophageal reflux. Poor sleep quality increases oesophageal hypersensitivity and overall acid exposure. The nocturnal gastro\u2010oesophageal reflux is linked to the more severe forms of gastro\u2010oesophageal reflux disease, especially with atypical\/extra\u2010oesophageal manifestations and complications of mucosal damage such as oesophagitis and stricture, Barret's oesophagus, and oesophageal adenocarcinoma. This review highlights the role of sleep problems in presenting nocturnal gastro\u2010oesophageal reflux, and the potential benefits of treating sleep disturbances in enhancing patient care and quality of life.<\/jats:p>","DOI":"10.1111\/jsr.14158","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T05:50:28Z","timestamp":1707976228000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Wake up to gastro\u2010oesophageal reflux disease: The interplay between arousal and night\u2010time reflux"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9848-3179","authenticated-orcid":false,"given":"Hanan","family":"Elkalawy","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Perioperative Care Tufts Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wael","family":"Abosena","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine Tanta University  Gharbeya Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Elnagger","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hartford Health Care  Hartford Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harmony","family":"Allison","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Tufts Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ctg.2014.8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2018.02.041"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/dote.12495"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/26.3.342"},{"issue":"4","key":"e_1_2_9_6_1","first-page":"421","article-title":"Cisapride and metoclopramide in the treatment of gastroesophageal reflux disease","volume":"10","author":"Arabehety J. 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