{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:26:19Z","timestamp":1792725979060,"version":"4.5.0"},"reference-count":66,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860307"],"award-info":[{"award-number":["81860307"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This study investigated the abnormal dynamic functional connectivity (dFC) variability of the thalamo\u2010cortical circuit in patients with obstructive sleep apnea (OSA) and explored the relationship between these changes and the clinical characteristics of patients with OSA. A total of 91 newly diagnosed patients with moderate\u2010to\u2010severe OSA and 84 education\u2010matched healthy controls (HCs) were included. All participants underwent neuropsychological testing and a functional magnetic resonance imaging scan. We explored the thalamo\u2010cortical dFC changes by dividing the thalamus into 16 subregions and combining them using a sliding\u2010window approach. Correlation analysis assessed the relationship between dFC variability and clinical features, and the support vector machine method was used for classification. The OSA group exhibited increased dFC variability between the thalamic subregions and extensive cortical areas, compared with the HCs group. Decreased dFC variability was observed in some frontal\u2010occipital\u2010temporal cortical regions. These dFC changes positively correlated with daytime sleepiness, disease severity, and cognitive scores. Altered dFC variability contributed to the discrimination between patients with OSA and HCs, with a classification accuracy of 77.8%. Our findings show thalamo\u2010cortical overactivation and disconnection in patients with OSA, disrupting information flow within the brain networks. These results enhance understanding of the temporal variability of thalamo\u2010cortical circuits in patients with OSA.<\/jats:p>","DOI":"10.1111\/jsr.14159","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T08:01:36Z","timestamp":1707292896000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Abnormal temporal variability of thalamo\u2010cortical circuit in patients with moderate\u2010to\u2010severe obstructive sleep apnea"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3424-8421","authenticated-orcid":false,"given":"Ting","family":"Long","sequence":"first","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital, Jiangxi Medical College, Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqiang","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital, Jiangxi Medical College, Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital, Jiangxi Medical College, Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital, Jiangxi Medical College, Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital, Jiangxi Medical College, Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital, Jiangxi Medical College, Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital, Jiangxi Medical College, Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital, Jiangxi Medical College, Nanchang University  Nanchang China"},{"name":"PET Center The First Affiliated Hospital of Nanchang University  Nanchang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0835-3375","authenticated-orcid":false,"given":"Dechang","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital, Jiangxi Medical College, Nanchang University  Nanchang China"},{"name":"PET Center The First Affiliated Hospital of Nanchang University  Nanchang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww083"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs352"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.4986"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2021.09.044"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2020.01.010"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1889"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2010.00013"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00363"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2022.04.005"},{"issue":"8","key":"e_1_2_12_12_1","first-page":"1103","article-title":"Neural alterations and depressive symptoms in obstructive sleep apnea patients","volume":"31","author":"Cross R. 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