{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T13:05:32Z","timestamp":1792242332063,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,24]],"date-time":"2024-03-24T00:00:00Z","timestamp":1711238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Insomnia disorder may affect mental health, increasing suicidal risk. Targeting insomnia is crucial in the clinical practice. Sixty\u2010six consecutive patients with insomnia disorder according with the DSM\u20105\u2010TR criteria were treated with the dual orexin receptor antagonist, daridorexant 50\u2009mg. Baseline (T0), 1\u2009month (T1) and 3\u2009month (T2) evaluations were performed. Insomnia severity (Insomnia Severity Index), mood, anxiety symptoms and suicidal risk (Beck Depression Inventory\u2010II, Young Mania Rating Scale, Self\u2010Reported Anxiety Scale, Suicidal Ideation Scale), dysfunctional insomnia\u2010cognitive factors and pre\u2010sleep arousal (Dysfunctional Beliefs About Sleep, Pre\u2010Sleep Arousal Scale) were evaluated. The final sample included 66 patients (\n                    <jats:italic>n<\/jats:italic>\n                    \u2005=\u200936, 54% females, mean age 60\u2009\u00b1\u200913.6\u2009years). Most of them, 64%, suffered from insomnia disorder comorbid with unipolar\/bipolar depression, anxiety disorders and substance use disorders. Repeated ANOVA analyses showed that Insomnia Severity Index, Dysfunctional Beliefs About Sleep and Pre\u2010Sleep Arousal Scale total score decreased across time (\n                    <jats:italic>F<\/jats:italic>\n                    \u2009=\u200968.818,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001;\n                    <jats:italic>F<\/jats:italic>\n                    \u2009=\u200947.561,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001;\n                    <jats:italic>F<\/jats:italic>\n                    \u2009=\u200928.142,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001, respectively). Similarly, Beck Depression Inventory\u2010II, Self\u2010Reported Anxiety Scale, Young Mania Rating Scale, and Suicidal Ideation Scale significantly decreased over time (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Predictors of insomnia remission (Insomnia Severity Index\u2009&lt;\u20098) at T1 were improvement of Insomnia Severity Index at T1 (\n                    <jats:italic>F<\/jats:italic>\n                    \u2009=\u200960.205,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), and improvement of Dysfunctional Beliefs About Sleep at T1 (\n                    <jats:italic>F<\/jats:italic>\n                    \u2009=\u20094.432,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.041). Insomnia remission at T2 was best predicted by improvement of Dysfunctional Beliefs About Sleep at T2 (\n                    <jats:italic>F<\/jats:italic>\n                    \u2009=\u20093.993,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.023). Multiple\u2010regression models showed that clinical improvement of Beck Depression Inventory\u2010II was best predicted by improvement in Dysfunctional Beliefs About Sleep at T1 and T2, manic symptoms by Insomnia Severity Index at T2, anxiety symptoms by Dysfunctional Beliefs About Sleep, Insomnia Severity Index and somatic Pre\u2010Sleep Arousal Scale at T1 and T2. With the caution of a naturalistic design, early experience with daridorexant showed that by targeting insomnia it may be possible to improve not only insomnia symptoms but also comorbid symptoms.\n                  <\/jats:p>","DOI":"10.1111\/jsr.14196","type":"journal-article","created":{"date-parts":[[2024,3,24]],"date-time":"2024-03-24T19:48:40Z","timestamp":1711309720000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Early experience with the new\n                    <scp>DORA<\/scp>\n                    daridorexant in patients with insomnia disorder and comorbid mental disturbances: Results of a naturalistic study with 3\u2009months follow\u2010up"],"prefix":"10.1111","volume":"33","author":[{"given":"Laura","family":"Palagini","sequence":"first","affiliation":[{"name":"Department of Neuroscience Section of Psychiatry, University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaspare","family":"Alfi","sequence":"additional","affiliation":[{"name":"Department of Surgical Medical, Molecular, and Critical Area Pathology, University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Gurrieri","sequence":"additional","affiliation":[{"name":"Department of Surgical Medical, Molecular, and Critical Area Pathology, University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Annuzzi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Section of Psychiatry, University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Caruso","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Section of Psychiatry, University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Gambini","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Section of Psychiatry, University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Grenno","sequence":"additional","affiliation":[{"name":"Department of Surgical Medical, Molecular, and Critical Area Pathology, University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Trivella","sequence":"additional","affiliation":[{"name":"Department of Surgical Medical, Molecular, and Critical Area Pathology, University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio","family":"Presta","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Section of Psychiatry, University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Miniati","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Section of Psychiatry, University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Pini","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Section of Psychiatry, University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Perugi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Section of Psychiatry, University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Gemignani","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Section of Psychiatry, University of Pisa  Pisa Italy"},{"name":"Department of Surgical Medical, Molecular, and Critical Area Pathology, University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425787"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2023.101878"},{"key":"e_1_2_10_5_1","volume-title":"La Depressione","author":"Beck A. 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