{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:11:48Z","timestamp":1785111108139,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:00:00Z","timestamp":1713830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Sleep\u2010disordered breathing is common among children with spinal muscular atrophy, but has been hardly studied among adult subjects. Little is known about sleep quality in spinal muscular atrophy. The aims of this study were to evaluate occurrence and characteristics of sleep\u2010disordered breathing and subjective sleep quality among adolescent and adult patients with spinal muscular atrophy type 2 or 3. Twenty patients aged 33.9\u2009\u00b1\u200915.2\u2009years were studied. They underwent nocturnal cardiorespiratory monitoring, lung and muscular function evaluation, and were administered the Pittsburgh Sleep Quality Index questionnaire. Nineteen patients showed sleep\u2010disordered breathing, with obstructive events in seven subjects and non\u2010obstructive events in the remaining 12. In the latter group, 10 patients showed pseudo\u2010obstructive hypopneas. Patients with non\u2010obstructive sleep\u2010disordered breathing were younger (<jats:italic>p<\/jats:italic>\u2009=\u20090.042), had a lower body mass index (<jats:italic>p<\/jats:italic>\u2009=\u20090.0001), were more often affected by spinal muscular atrophy type 2 (<jats:italic>p<\/jats:italic>\u2009=\u20090.001), and showed worse impairment of respiratory function than patients with obstructive sleep\u2010disordered breathing. Ten patients were classified as poor sleepers and 10 patients good sleepers. In the whole sample, sniff nasal inspiratory pressure proved to be the only independent predictor of sleep quality (<jats:italic>p<\/jats:italic>\u2009=\u20090.009). In conclusion, sleep\u2010disordered breathing is common even among adult patients with spinal muscular atrophy type 2 and 3, and may show either obstructive or different types on non\u2010obstructive features. A worse respiratory muscle function is associated to non\u2010obstructive sleep\u2010disordered breathing and poorer sleep quality. Sleep quality should receive greater attention especially in patients with spinal muscular atrophy type 2, who have a poorer respiratory muscle function, as it could affect their quality of life.<\/jats:p>","DOI":"10.1111\/jsr.14222","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T04:49:31Z","timestamp":1713934171000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Spectrum of sleep\u2010disordered breathing and quality of sleep in adolescent and adult patients with spinal muscular atrophy"],"prefix":"10.1111","volume":"33","author":[{"given":"Grazia","family":"Crescimanno","sequence":"first","affiliation":[{"name":"National Research Council Institute of Biomedical Research and Innovation (IRIB\u2010CNR)  Palermo Italy"},{"name":"Regional Center for Diagnosis and Treatment of Neuromuscular Disease, Department of Biomedicine, Neuroscience and Advanced Diagnostic (BIND) University of Palermo  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Lupica","sequence":"additional","affiliation":[{"name":"Regional Center for Diagnosis and Treatment of Neuromuscular Disease, Department of Biomedicine, Neuroscience and Advanced Diagnostic (BIND) University of Palermo  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vito","family":"Tommasello","sequence":"additional","affiliation":[{"name":"Regional Center for Diagnosis and Treatment of Neuromuscular Disease, Department of Biomedicine, Neuroscience and Advanced Diagnostic (BIND) University of Palermo  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Di Stefano","sequence":"additional","affiliation":[{"name":"Regional Center for Diagnosis and Treatment of Neuromuscular Disease, Department of Biomedicine, Neuroscience and Advanced Diagnostic (BIND) University of Palermo  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Brighina","sequence":"additional","affiliation":[{"name":"Regional Center for Diagnosis and Treatment of Neuromuscular Disease, Department of Biomedicine, Neuroscience and Advanced Diagnostic (BIND) University of Palermo  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6819-7928","authenticated-orcid":false,"given":"Oreste","family":"Marrone","sequence":"additional","affiliation":[{"name":"National Research Council Institute of Biomedical Research and Innovation (IRIB\u2010CNR)  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2017.03.023"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.14-1-72"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.01302001a"},{"issue":"4","key":"e_1_2_10_5_1","first-page":"318","article-title":"Sleep disorders in neuromuscular diseases","volume":"48","author":"Cerveri I.","year":"1993","journal-title":"Monaldi Archives for Chest Disease"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2019.12.004"},{"issue":"10","key":"e_1_2_10_7_1","first-page":"1675","article-title":"Sleep disordered breathing in children with neuromuscular disease","volume":"10","author":"Chidambaram A. 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