{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T06:36:07Z","timestamp":1784874967397,"version":"3.55.0"},"reference-count":117,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T00:00:00Z","timestamp":1716422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The formal identification and naming of rapid eye movement (REM) sleep behaviour disorder (RBD) in 1985\u20131987 is described; the historical background of RBD from 1966 to 1985 is briefly discussed; and RBD milestones are presented. Current knowledge on RBD is identified with reference to recent comprehensive reviews, allowing for a focus on research priorities for RBD: factors and predictors of neurodegenerative phenoconversion from isolated RBD and patient enrolment in neuroprotective trials; isolated RBD clinical research cohorts; epidemiology of RBD; traumatic brain injury, post\u2010traumatic stress disorder, RBD and neurodegeneration; depression, RBD and synucleinopathy; evolution of prodromal RBD to neurodegeneration; gut microbiome dysbiosis and colonic synuclein histopathology in isolated RBD; other alpha\u2010synuclein research in isolated RBD; narcolepsy\u2010RBD; dreams and nightmares in RBD; phasic REM sleep in isolated RBD; RBD, periodic limb movements, periodic limb movement disorder pseudo\u2010RBD; other neurophysiology research in RBD; cardiac scintigraphy (<jats:sup>123<\/jats:sup>I\u2010MIBG) in isolated RBD; brain magnetic resonance imaging biomarkers in isolated RBD; microRNAs as biomarkers in isolated RBD; actigraphic, other automated digital monitoring and machine learning research in RBD; prognostic counselling and ethical considerations in isolated RBD; and REM sleep basic science research. RBD research is flourishing, and is strategically situated at an ever\u2010expanding crossroads of clinical (sleep) medicine, neurology, psychiatry and neuroscience.<\/jats:p>","DOI":"10.1111\/jsr.14228","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T02:55:10Z","timestamp":1716519310000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["<scp>REM<\/scp> sleep behaviour disorder (<scp>RBD<\/scp>): Personal perspectives and research priorities"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0095-2680","authenticated-orcid":false,"given":"Carlos H.","family":"Schenck","sequence":"first","affiliation":[{"name":"Minnesota Regional Sleep Disorders Center, Department of Psychiatry Hennepin County Medical Center and University of Minnesota Medical School  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,23]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"International classification of sleep disorders","author":"American Academy of Sleep Medicine","year":"2023"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.50833"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.16001"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26902"},{"key":"e_1_2_10_6_1","first-page":"223","volume-title":"Rapid\u2010Eye\u2010Movement Sleep Behavior Disorder","author":"Arnulf I.","year":"2018"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006366"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000207748"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.16260"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2015.12.002"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-022-11213-9"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.14109"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1109\/EMBC40787.2023.10341133"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2020.01.010"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.2147\/NSS.S423878"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2024.101898"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsae002"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000208008"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.9416"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-015-1557-1"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0016-5"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2021.04.007"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsae007"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51738"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsz237"},{"key":"e_1_2_10_26_1","article-title":"PLMS and autonomic activation in patients with restless legs syndrome and REM sleep behavior disorder","volume":"24","author":"Fantini L.","year":"2001","journal-title":"Sleep"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000179346.39655.e0"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000038348.94399.f6"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.13768"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsab259"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz111"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.13880"},{"key":"e_1_2_10_33_1","first-page":"71","volume-title":"The unconscious: Nature, functions, methods of study","author":"Fisher C.","year":"1978"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsw063"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsad030"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsac244"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci13101398"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsx197"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2024.01.019"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsae074"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.134.12.1335"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.13612"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-38248-4"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-200103000-00005"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000207147"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/28.2.203"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70056-5"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsae031"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10204709"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2017.08.468"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.21050115"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad072"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.2874"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-35209-1"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2023.107496"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000207947"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-023-00628-4"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000200707"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1520\/JFS12842J"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/14.1.69"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1520\/JFS2002399"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/30.12.1779"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsz064"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/31.5.717"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.2.331"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2012.01.009"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsae052"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsad132"},{"key":"e_1_2_10_69_1","volume-title":"An essay on the shaking palsy [monograph]","author":"Parkinson J.","year":"1817"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000200235"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz030"},{"key":"e_1_2_10_72_1","first-page":"153","volume-title":"Rapid\u2010Eye\u2010Movement Sleep Behavior Disorder","author":"Provini F.","year":"2018"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2017.07.021"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-022-06374-4"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsz128.47"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000208015"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2023.08.006"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26085"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsad310"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics14040363"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsaa024"},{"key":"e_1_2_10_82_1","volume-title":"Paradox lost: Midnight in the battleground of sleep and dreams","author":"Schenck C. H.","year":"2005"},{"key":"e_1_2_10_83_1","first-page":"vii","volume-title":"Rapid\u2010Eye\u2010Movement Sleep Behavior Disorder","author":"Schenck C. H.","year":"2018"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-022-02574-6"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.3390\/ctn7030019"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2012.10.009"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/20.11.972"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/9.2.293"},{"key":"e_1_2_10_89_1","first-page":"208","article-title":"Human REM sleep chronic behavior disorders: A new category of parasomnia","volume":"14","author":"Schenck C. H.","year":"1985","journal-title":"Sleep Research"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.2.388"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1987.03390130104038"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410390216"},{"key":"e_1_2_10_93_1","volume-title":"Rapid\u2010Eye\u2010Movement Sleep Behavior Disorder","author":"Schenck C. H.","year":"2018"},{"key":"e_1_2_10_94_1","first-page":"579","volume-title":"Rapid\u2010Eye\u2010Movement Sleep Behavior Disorder","author":"Schenck H.","year":"2018"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.145.5.652a"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.1993.tb00093.x"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410320103"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/25.2.120"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/15.3.226"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.146.9.1166"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.2147\/NSS.S435201"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2019.e03140"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-1777111"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsad109"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-2019-0245"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26835"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsy227"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsaa160"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2009.08.002"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2020.12.012"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2023.105956"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2022.08.018"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-83980-w"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-023-01322-x"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2021-327460"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2022-330922"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-024-00682-6"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26298"}],"container-title":["Journal of Sleep Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsr.14228","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T15:54:49Z","timestamp":1743263689000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jsr.14228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,23]]},"references-count":117,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/jsr.14228"],"URL":"https:\/\/doi.org\/10.1111\/jsr.14228","archive":["Portico"],"relation":{},"ISSN":["0962-1105","1365-2869"],"issn-type":[{"value":"0962-1105","type":"print"},{"value":"1365-2869","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,23]]},"assertion":[{"value":"2024-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14228"}}