{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:28:38Z","timestamp":1788344918764,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007605","name":"Aarhus Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007605","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012774","name":"Innovationsfonden","doi-asserted-by":"publisher","award":["7038\u201000157B"],"award-info":[{"award-number":["7038\u201000157B"]}],"id":[{"id":"10.13039\/100012774","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Many patients with depression report insomnia symptoms that profoundly affect their health and well\u2010being. Non\u2010pharmacological treatments of insomnia may be preferable for some patients. In this randomised crossover trial, we investigated the efficacy of the Protac Ball Blanket\u00ae on insomnia among patients with depression. Included patients (<jats:italic>n<\/jats:italic>\u2009=\u200945) were diagnosed with unipolar depression, and with subjective insomnia and poor sleep quality (Pittsburgh Sleep Quality Index Score &gt; 5). Each patient slept 2\u2009weeks with a Protac Ball Blanket\u00ae and 2\u2009weeks with a control duvet. Randomisation defined the order of the 2\u2010week sleep periods. Patients served as their own control in this design. The primary outcome was changes in total night\u2010time sleep. Secondary outcomes were sleep\u2010onset latency, number of awakenings, wake after sleep onset, daily use of pro necessitate sedatives and hypnotics, subjective sleep quality (Pittsburgh Sleep Quality Index), insomnia severity (Insomnia Severity Index), symptoms of depression (Hamilton Depression Rating Scale, Major Depression Inventory), symptoms of anxiety (Beck Anxiety Index), and patient\u2010reported outcomes concerning interpersonal sensitivity, neurasthenia, anxiety and depression (Self\u2010Reported Symptom State Scale). Paired two\u2010sided <jats:italic>t<\/jats:italic>\u2010tests were used to compare the means of the differences of the outcomes. Protac Ball Blanket\u00ae increased total night\u2010time sleep by 12.9 min (95% confidence interval: 1.21\u201324.63, <jats:italic>p<\/jats:italic>\u2009=\u20090.031). Among the secondary outcomes, Protac Ball Blanket\u00ae decreased Hamilton Depression Rating Scale by 2.78 (95% confidence interval: \u22125.44; \u22120.11, <jats:italic>p<\/jats:italic>\u2009=\u20090.042) and Insomnia Severity Index by 2.98 (95% confidence interval: \u22125.45; \u22120.50, <jats:italic>p<\/jats:italic>\u2009=\u20090.020). No changes were observed in sleep\u2010onset latency, number of awakenings, wake after sleep onset, Pittsburgh Sleep Quality Index, Major Depression Inventory, Beck Anxiety Index, Self\u2010Reported Symptom State Scale, and medication use. The results suggest that some patients may benefit from Protac Ball Blanket\u00ae as an add\u2010on non\u2010pharmacological treatment to improve sleep in depression.<\/jats:p>","DOI":"10.1111\/jsr.14238","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T00:44:20Z","timestamp":1715647460000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The efficacy of ball blankets on insomnia in depression in outpatient clinics: A randomised crossover multicentre trial"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1309-6761","authenticated-orcid":false,"given":"Sanne Toft","family":"Kristiansen","sequence":"first","affiliation":[{"name":"Research Unit for Nursing and Healthcare, Department of Public Health, Health Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poul","family":"Videbech","sequence":"additional","affiliation":[{"name":"Centre for Neuropsychiatric Depression Research Mental Health Centre Glostrup  Glostrup Denmark"},{"name":"Clinical Institute University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Speed","sequence":"additional","affiliation":[{"name":"Department of Affective Disorders Aarhus University Hospital\u2010Psychiatry  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Dionysopoulos","sequence":"additional","affiliation":[{"name":"Sleep Medicine The Royal Melbourne Hospital\u2014City Campus  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merete Bender","family":"Bjerrum","sequence":"additional","affiliation":[{"name":"Research Unit for Nursing and Healthcare, Department of Public Health, Health Aarhus University  Aarhus Denmark"},{"name":"Centre of Clinical Guidelines\u2014Danish National Clearing House, Department of Clinical Medicine Aalborg University  Aalborg Denmark"},{"name":"Danish Centre of Systematic Reviews A JBI Centre of Excellence  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik Roj","family":"Larsen","sequence":"additional","affiliation":[{"name":"Translational Neuropsychiatry Unit, Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,13]]},"reference":[{"issue":"3","key":"e_1_2_10_2_1","first-page":"1022","article-title":"Positive effects of a weighted blanket on insomnia","volume":"2","author":"Ackerley P.","year":"2015","journal-title":"Journal of Sleep Medicine and Disorders"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2011.01.011"},{"key":"e_1_2_10_4_1","volume-title":"Rating Scales for Affektive Lidelser","author":"Bech P.","year":"2005"},{"key":"e_1_2_10_5_1","volume-title":"Beck anxiety inventory manual","author":"Beck A.","year":"1993"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2007.10.008"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.7326\/M17-0046"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(89)90047-4"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/0164212X.2015.1066220"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/15.5.461"},{"key":"e_1_2_10_11_1","unstructured":"Denmark I. 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