{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T03:18:14Z","timestamp":1785295094340,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T00:00:00Z","timestamp":1725667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Parasomnias and sleep\u2010related movement disorders (SRMD) are major causes of sleep disorders and may be drug induced. The objective of this study was to conduct a systematic review of the literature to examine the association between drug use and the occurrence of parasomnias and SRMD. Following Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses guidelines for reporting systematic reviews, we searched PubMed databases between January 2020 and June 2023. The searches retrieved 937 records, of which 174 publications were selected for full\u2010text screening and 73 drugs were identified. The most common drug\u2010induced parasomnias were nightmares and rapid eye movement (REM) sleep behaviour disorders and sleepwalking. In terms of drug\u2010induced SRMD, restless legs syndrome, periodic limb movement disorders (PLMD), and sleep\u2010related bruxism were most frequent. Medications that inhibit noradrenergic, serotonergic, or orexin transmission could induce REM sleep (e.g., nightmares). Regarding sleepwalking, dysregulation of serotoninergic neurone activity is implicated. Antipsychotics are mentioned, as well as medications involved in the gamma\u2010aminobutyric acid (GABA) pathway. A mechanism of desensitisation\u2010autoregulation of GABA receptors on serotoninergic neurones is a hypothesis. SRMD and PLMD could involve medications disrupting the dopamine pathway (e.g., antipsychotics or opioids). Opioids would act on mu receptors and increase dopamine release. The role of adenosine and iron is also hypothesised. Regarding bruxism, the hypotheses raised involve dysregulation of mesocortical pathway or a downregulation of nigrostriatal pathway, related to medications involving dopamine or serotonin. Parasomnias are rarely identified in drug product labels, likely due to the recent classification of their diagnoses. An analysis of pharmacovigilance data could be valuable to supplement existing literature data.<\/jats:p>","DOI":"10.1111\/jsr.14306","type":"journal-article","created":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T10:14:04Z","timestamp":1725704044000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Parasomnias and sleep\u2010related movement disorders induced by drugs in the adult population: a review about iatrogenic medication effects"],"prefix":"10.1111","volume":"34","author":[{"given":"Sylvain","family":"Dumont","sequence":"first","affiliation":[{"name":"Service Pharmacie AP\u2010HP, GHU Paris Nord, DMU PRISME, H\u00f4pital Bichat\u2010Claude Bernard  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Bloch","sequence":"additional","affiliation":[{"name":"Service Pharmacie AP\u2010HP, GHU Paris Nord, DMU PRISME, H\u00f4pital Larboisi\u00e8re\u2010Fernand Widal  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Lillo\u2010Lelouet","sequence":"additional","affiliation":[{"name":"Centre R\u00e9gional de Pharmacovigilance, H\u00f4pital Europ\u00e9en Georges Pompidou  Paris France"},{"name":"Universit\u00e9 Paris Cit\u00e9, Innovative Therapies in Hemostasis, INSERM  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6339-0478","authenticated-orcid":false,"given":"Christine","family":"Le Beller","sequence":"additional","affiliation":[{"name":"Centre R\u00e9gional de Pharmacovigilance, H\u00f4pital Europ\u00e9en Georges Pompidou  Paris France"},{"name":"Universit\u00e9 Paris Cit\u00e9, Innovative Therapies in Hemostasis, INSERM  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre A.","family":"Geoffroy","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Psychiatrie et d'Addictologie AP\u2010HP, GHU Paris Nord, DMU Neurosciences, H\u00f4pital Bichat \u2010 Claude Bernard  Paris France"},{"name":"Centre ChronoS, GHU Paris \u2010 Psychiatry and Neurosciences  Paris France"},{"name":"Universit\u00e9 Paris Cit\u00e9, NeuroDiderot, INSERM  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6135-9916","authenticated-orcid":false,"given":"Marc","family":"Veyrier","sequence":"additional","affiliation":[{"name":"Service Pharmacie AP\u2010HP, GHU Paris Nord, DMU PRISME, H\u00f4pital Bichat\u2010Claude Bernard  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9123990"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.11040096"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2010.07.011"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/33.5.585"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/00207454.2010.520541"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2006.09.002"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.4314\/mmj.v30i1.9"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2014.947262"},{"issue":"2","key":"e_1_2_9_11_1","first-page":"182","article-title":"Major neurotransmitters involved in the regulation of sleep\u2010wake cycle","volume":"64","author":"Franco\u2010P\u00e9rez J.","year":"2012","journal-title":"Revista de Investigaci\u00f3n Cl\u00ednica"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2190\/PM.48.3.d"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2020.02.018"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.332.7547.950"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2007.01966.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852900015698"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.1.177"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2011.04.019"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2004.06.013"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2011.00071"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2009.10.006"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/154411130301400104"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleh.2017.07.006"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-011-0905-9"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2012(02)17"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2010.07.005"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.19.2323"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.169.4.459"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.26919"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2009.12.006"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01283029"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-0970"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11126-010-9149-8"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa072743"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.6600"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2004.09.006"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30311-9"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNF.0000000000000108"},{"key":"e_1_2_9_40_1","volume-title":"WHO pharmacovigilance indicators: A practical manual for the assessment of pharmacovigilance systems","author":"World Health Organization","year":"2015"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02354268"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.005947"}],"container-title":["Journal of Sleep Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsr.14306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T15:54:11Z","timestamp":1743263651000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jsr.14306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,7]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/jsr.14306"],"URL":"https:\/\/doi.org\/10.1111\/jsr.14306","archive":["Portico"],"relation":{},"ISSN":["0962-1105","1365-2869"],"issn-type":[{"value":"0962-1105","type":"print"},{"value":"1365-2869","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,7]]},"assertion":[{"value":"2024-01-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14306"}}