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Here, we established mouse CLAS (mCLAS)\u2010mediated SWA enhancement and explored its effects on sleep deficits in neurodegeneration, by targeting the up\u2010phase of slow waves in mouse models of Alzheimer's disease (AD, Tg2576) and Parkinson's disease (PD, M83). We found that tracking a 2\u2009Hz component of slow waves leads to highest precision of non\u2010rapid eye movement (NREM) sleep detection in mice, and that its combination with a 30\u00b0 up\u2010phase target produces a significant 15\u201330% SWA increase from baseline in wild\u2010type (WT\n                    <jats:sub>AD<\/jats:sub>\n                    )\u00a0and transgenic (TG\n                    <jats:sub>AD<\/jats:sub>\n                    ) mice versus a mock stimulation group. Conversely, combining 2\u2009Hz with a 40\u00b0 phase target yields a significant increase ranging 30\u201335% in WT\n                    <jats:sub>PD<\/jats:sub>\n                    and TG\n                    <jats:sub>PD<\/jats:sub>\n                    mice. Interestingly, these phase\u2010target\u2010triggered SWA increases are not genotype dependent but strain specific. Sleep alterations that may contribute to disease progression and burden were described in AD and PD lines. Notably, pathological sleep traits were rescued by mCLAS, which elicited a 14% decrease of pathologically heightened NREM sleep fragmentation in TG\n                    <jats:sub>AD<\/jats:sub>\n                    mice, accompanied by a steep decrease in microarousal events during both light and dark periods. Overall, our results indicate that model\u2010tailored phase targeting is key to modulate SWA through mCLAS, prompting the acute alleviation of key neurodegeneration\u2010associated sleep phenotypes and potentiating sleep regulation and consolidation. Further experiments assessing the long\u2010term effect of mCLAS in neurodegeneration may majorly impact the establishment of sleep\u2010based therapies.\n                  <\/jats:p>","DOI":"10.1111\/jsr.14316","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T01:35:25Z","timestamp":1725327325000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Novel murine closed\u2010loop auditory stimulation paradigm elicits macrostructural sleep benefits in neurodegeneration"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5404-4506","authenticated-orcid":false,"given":"In\u00eas","family":"Dias","sequence":"first","affiliation":[{"name":"Department of Neurology University Hospital Zurich (USZ)  Schlieren Switzerland"},{"name":"Department of Health Sciences and Technology (D\u2010HEST) ETH Zurich  Zurich Switzerland"},{"name":"Neuroscience Center Zurich (ZNZ) University of Zurich (UZH)  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sedef","family":"Kollarik","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Zurich (USZ)  Schlieren Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Siegel","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Zurich (USZ)  Schlieren Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3417-1978","authenticated-orcid":false,"given":"Christian R.","family":"Baumann","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Zurich (USZ)  Schlieren Switzerland"},{"name":"Neuroscience Center Zurich (ZNZ) University of Zurich (UZH)  Zurich Switzerland"},{"name":"Center of Competence Sleep and Health University of Zurich (UZH)  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos G.","family":"Moreira","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Zurich (USZ)  Schlieren Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5482-7933","authenticated-orcid":false,"given":"Daniela","family":"Noain","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Zurich (USZ)  Schlieren Switzerland"},{"name":"Neuroscience Center Zurich (ZNZ) University of Zurich (UZH)  Zurich Switzerland"},{"name":"Center of Competence Sleep and Health University of Zurich (UZH)  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2018.00248"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.3171"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000000329"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CUB.2018.01.087"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13855"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-42100-5"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15405"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.3390"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1109\/LSENS.2019.2914425"},{"key":"e_1_2_10_11_1","volume-title":"Discovering statistics using IBM SPSS statistics","author":"Field A.","year":"2013"},{"key":"e_1_2_10_12_1","first-page":"521","volume-title":"Neuron","author":"Giasson B. 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