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Agrypnia excitata is characterized by a severe loss of sleep leading to a complete derangement of physiological sleep\u2013wake cycle and body homeostasis. Agrypnia excitata is a definite clinico\u2010neurophysiological condition characterized by: (1) slow\u2010wave sleep loss with disruption of sleepwake cycle; (2) a 24\u2010hr motor and autonomic overactivity; and (3) peculiar episodes of oneiric stupor. 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