{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:49:14Z","timestamp":1790192954927,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T00:00:00Z","timestamp":1726531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF21OC0065373"],"award-info":[{"award-number":["NNF21OC0065373"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001732","name":"Danmarks Grundforskningsfond","doi-asserted-by":"publisher","award":["DNRF121"],"award-info":[{"award-number":["DNRF121"]}],"id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Sleep disturbances exacerbate chronic pain, increase psychological load, and increase inflammation. Delayed onset muscle soreness (DOMS) mimics aspects of chronic pain, predominantly affecting peripheral pain mechanisms, while experimental sleep provocations have been shown to impact central pain mechanisms. This study aimed to combine a DOMS model with total sleep deprivation (TSD) to create a novel model affecting both peripheral and central pain mechanisms. A total of 30 healthy participants attended two sessions (baseline and follow\u2010up) separated by 24\u2009h of TSD and a home rating after 48\u2009h. Assessments of interleukin 6 (IL\u20106) levels, sleep quality, pain catastrophising, affect, and symptoms of depression and anxiety were included in the baseline and follow\u2010up sessions. Additionally, pressure pain and tolerance thresholds, temporal summation, and conditioned pain modulation (CPM) were assessed using cuff\u2010pressure algometry in the baseline and follow\u2010up sessions. DOMS was induced with eccentric calf raises during the baseline session followed by 24\u2009h of TSD. At follow\u2010up pain tolerance (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.012) was significantly reduced, and CPM (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.036) was significantly impaired compared to baseline. Psychological changes included decreases in pain catastrophising (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.027), positive affect (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), negative affect (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.003), and anxiety (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.012). Explorative regression models predicted 58% and 68% of DOMS pain intensity after 24 and 48\u2009h, respectively, based on baseline body mass index, pain thresholds, psychological measures, and IL\u20106 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). Combining DOMS with 1\u2009night of TSD induced pain hypersensitivity, impaired CPM, and altered psychological states. A combination of baseline inflammation, psychological measures, and pain sensitivity significantly predicted DOMS pain intensity after 24 and 48\u2009h.\n                  <\/jats:p>","DOI":"10.1111\/jsr.14329","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T00:53:56Z","timestamp":1726620836000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Psychophysical changes after total sleep deprivation and experimental muscle pain"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4283-2094","authenticated-orcid":false,"given":"Emma","family":"Hertel","sequence":"first","affiliation":[{"name":"Faculty of Medicine Aalborg University  Aalborg Denmark"},{"name":"Mathemathical Modeling of Knee Osteoarthritis (MathKOA) Aalborg University  Aalborg 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Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian Kj\u00e6r\u2010Staal","family":"Petersen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Aalborg University  Aalborg Denmark"},{"name":"Mathemathical Modeling of Knee Osteoarthritis (MathKOA) Aalborg University  Aalborg Denmark"},{"name":"Center for Neuroplasticity and Pain (CNAP) Aalborg University  Aalborg 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