{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:40:07Z","timestamp":1791384007236,"version":"4.3.3"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T00:00:00Z","timestamp":1729468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    The aim of the present study was to examine gender and age\u2010specific effects on subjective daytime sleepiness (as measured by the Epworth Sleepiness Scale), body weight and eating behaviour in patients with central disorders of hypersomnolence. Based on the European Narcolepsy Network database, we compared 1035 patients with narcolepsy type I and 505 patients with other central disorders of hypersomnolence (\u201cnarcoleptic borderland\u201d), including narcolepsy type II (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009308) and idiopathic hypersomnia (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009174), using logistic regression and general linear models. In the entire study population, the Epworth Sleepiness Scale was higher in women (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009735, mean age\u2009=\u200930\u2009years, mean Epworth Sleepiness Scale\u2009=\u200916.6 \u00b1 SD 3.9) than in men (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009805, mean age\u2009=\u200932\u2009years, mean Epworth Sleepiness Scale\u2009=\u200915.8 \u00b1 SD 4.4). In women with narcolepsy type I (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009475), both Epworth Sleepiness Scale and body mass index increased in parallel with age. In women of the narcoleptic borderland (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009260), the Epworth Sleepiness Scale markedly peaked in their early 30s, while body mass index only started to rise at that age. This rise in body mass index following the Epworth Sleepiness Scale peak cannot be explained by sleepiness\u2010induced uncontrolled eating, as self\u2010reported uncontrolled eating was negatively associated with the Epworth Sleepiness Scale in this group. We propose that the narcoleptic borderland harbours a unique cluster of women in their fertile years with an unexplored aetiology requiring further investigation towards tailored interventions.\n                  <\/jats:p>","DOI":"10.1111\/jsr.14365","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T03:11:00Z","timestamp":1729480260000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Daytime sleepiness and\n                    <scp>BMI<\/scp>\n                    exhibit gender and age differences in patients with central disorders of hypersomnolence"],"prefix":"10.1111","volume":"34","author":[{"given":"Laura","family":"Ferrazzini","sequence":"first","affiliation":[{"name":"Department of Neurology, Inselspital, Bern University Hospital University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Neurology, Inselspital, Bern University Hospital University of Bern  Bern Switzerland"},{"name":"Ohio Sleep Medicine Institute  Dublin Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongxing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Sleep Medicine, Sleep Research and Epileptology Klinik Barmelweid AG  Barmelweid Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramin","family":"Khatami","sequence":"additional","affiliation":[{"name":"Department of Neurology, Inselspital, Bern University Hospital University of Bern  Bern Switzerland"},{"name":"Center for Sleep Medicine, Sleep Research and Epileptology Klinik Barmelweid AG  Barmelweid Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0683-6506","authenticated-orcid":false,"given":"Yves","family":"Dauvilliers","sequence":"additional","affiliation":[{"name":"Sleep\u2010Wake Disorders Unit, Department of Neurology Gui\u2010de\u2010Chauliac University Hospital  Montpellier France"},{"name":"National Reference Centre for Narcolepsy and Rare Hypersomnias  Montpellier France"},{"name":"Institute of Neurosciences of Montpellier University of Montpellier, INSERM  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Barateau","sequence":"additional","affiliation":[{"name":"Sleep\u2010Wake Disorders Unit, Department of Neurology Gui\u2010de\u2010Chauliac University Hospital  Montpellier France"},{"name":"National Reference Centre for Narcolepsy and Rare Hypersomnias  Montpellier France"},{"name":"Institute of Neurosciences of Montpellier University of Montpellier, INSERM  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert","family":"Mayer","sequence":"additional","affiliation":[{"name":"Neurology Department, Hephata Klinik  Schwalmstadt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Pizza","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum University of Blogna  Bologna Italy"},{"name":"RCCS Istituto delle Scienze Neurologiche di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1051-0472","authenticated-orcid":false,"given":"Giuseppe","family":"Plazzi","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum University of Blogna  Bologna Italy"},{"name":"Department of Biomedical, Metabolic and Neural Sciences University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7480-7841","authenticated-orcid":false,"given":"Jari K.","family":"Gool","sequence":"additional","affiliation":[{"name":"Stichting Epilepsie Instellingen Nederlands (SEIN) Sleep\u2010wake Center  Heemstede the Netherlands"},{"name":"Leiden University Medical Center Department of Neurology  Leiden the Netherlands"},{"name":"Anatomy &amp; 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