{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:40:25Z","timestamp":1753879225281,"version":"3.41.2"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T00:00:00Z","timestamp":1728691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070092"],"award-info":[{"award-number":["82070092"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>To explore the association between the severity of sleep\u2010disordered breathing, different types of respiratory events, peripheral oxygen saturation (SpO<jats:sub>2<\/jats:sub>), age and sleep stage on cerebral oxygen saturation (rSO<jats:sub>2<\/jats:sub>) in children. We enrolled children aged 4\u201314\u2009years who were treated for snoring or mouth breathing at the Sleep Center of Beijing Children's Hospital, from February 2022 to July 2022. All children completed polysomnography, and SpO<jats:sub>2<\/jats:sub>, rSO<jats:sub>2<\/jats:sub>, and heart rate (HR) were recorded synchronously. A total of 70 children were included, including 16 (22.9%) with primary snoring, 38 (54.3%) with mild obstructive sleep apnea (OSA), and 16 (22.9%) with moderate\u2010to\u2010severe OSA. There were no significant differences in the mean rSO<jats:sub>2<\/jats:sub> or minimum rSO<jats:sub>2<\/jats:sub> among the primary snoring, mild OSA, and moderate\u2010to\u2010severe OSA groups (all <jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). A total of 1119 respiratory events were included in the analysis. Regardless of the type of respiratory event, rSO<jats:sub>2<\/jats:sub> and HR changes occur prior to fluctuations in SpO<jats:sub>2<\/jats:sub>. A mixed\u2010effects model showed that \u0394rSO<jats:sub>2<\/jats:sub> was positively correlated with \u0394SpO<jats:sub>2<\/jats:sub>, duration of respiratory event, mixed and obstructive apnea, central apnea, while negatively correlated with age and rapid eye movement (REM) sleep stage (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Larger rSO<jats:sub>2<\/jats:sub> fluctuations were impacted by a greater \u0394SpO<jats:sub>2<\/jats:sub>, longer duration of respiratory events, younger age, apnea\u2010related respiratory events and non\u2010REM sleep stage. Thus, sleep disordered breathing in younger children warrants more attention. More research is needed to determine whether REM sleep has special protective effects on rSO<jats:sub>2<\/jats:sub>.<\/jats:p>","DOI":"10.1111\/jsr.14366","type":"journal-article","created":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T09:00:21Z","timestamp":1728723621000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Study on cerebral oxygen saturation in children with sleep\u2010disordered breathing"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9046-7090","authenticated-orcid":false,"given":"Yunxiao","family":"Wu","sequence":"first","affiliation":[{"name":"School of Instrumentation Science and Optoelectronic Engineering Beihang University  Beijing China"},{"name":"Department of Otolaryngology, Head and Neck Surgery, Beijing Children's Hospital Capital Medical University, National Center for Children's Health  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhifei","family":"Xu","sequence":"additional","affiliation":[{"name":"Respiratory Department, Beijing Children's Hospital Capital Medical University, China National Clinical Research Center of Respiratory Diseases, National Center for Children's Health  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wentong","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Beijing Children's Hospital Capital Medical University, National Center for Children's Health  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Automation, Chinese Academy of Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Beijing Children's Hospital Capital Medical University, National Center for Children's Health  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolin","family":"Ning","sequence":"additional","affiliation":[{"name":"School of Instrumentation Science and Optoelectronic Engineering Beihang University  Beijing China"},{"name":"Key Laboratory of Ultra\u2010Weak Magnetic Field Measurement Technology, Ministry of Education, School of Instrumentation and Optoelectronic Engineering Beihang University  Beijing China"},{"name":"Institute of Large\u2010Scale Scientific Facility and Centre for Zero Magnetic Field Science Beihang University  Hangzhou China"},{"name":"National Institute of Extremely\u2010Weak Magnetic Field Infrastructure  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Beijing Children's Hospital Capital Medical University, National Center for Children's Health  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,12]]},"reference":[{"issue":"6","key":"e_1_2_12_2_1","first-page":"437","article-title":"Cerebral oxygenation during sleep in patients with obstructive sleep apnea: A near\u2010infrared spectroscopy study","volume":"41","author":"Akhan G.","year":"2012","journal-title":"Journal of Otolaryngology \u2013 Head & Neck Surgery"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00127603"},{"volume-title":"International classification of sleep disorders","year":"2014","author":"American Academy of Sleep Medicine","key":"e_1_2_12_4_1"},{"volume-title":"The AASM manual for the scoring of sleep and associated events: Rules,terminology, and technical specifications, version 2.6","year":"2020","author":"Berry R. 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