{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T13:18:04Z","timestamp":1784639884975,"version":"3.55.0"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T00:00:00Z","timestamp":1733097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Excessive daytime sleepiness is a possible symptom of post\u2010COVID syndrome and is also the cardinal symptom of narcolepsy, a rare life\u2010long sleep disorder with a possible autoimmune background. Recent reports indicate that COVID\u201019 infection may trigger narcolepsy. However, it remains unclear how best to identify and treat such cases. A 25\u2010year\u2010old male developed daytime sleepiness after COVID\u201019 infection. A diagnosis of narcolepsy type II was made based on pathologically shortened sleep latencies in polysomnography and multiple sleep latency tests (MSLT) together with several sleep\u2010onset REM\u2010sleep periods (SOREMs). Pupillography and neuropsychological testing revealed reduced alertness levels. Hypocretin levels in the cerebrospinal fluid were borderline. Based on the postulated autoimmune background of narcolepsy, we performed an intravenous high\u2010dose corticosteroid pulse therapy with methylprednisolone. Narcoleptic symptoms immediately and consistently remitted after the corticosteroid pulse. Follow\u2010up after 4 months revealed normalisation of sleep latencies, no further SOREMs in the MSLT, and increased alertness in pupillography and neurocognitive testing. No further wakefulness promoting drug therapy was required. Narcolepsy should be considered in the differential diagnosis of post\u2010COVID syndrome with leading symptoms of daytime sleepiness. Furthermore, immunosuppressive therapy may offer a treatment option in managing an otherwise lifelong disorder in select cases.<\/jats:p>","DOI":"10.1111\/jsr.14406","type":"journal-article","created":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T19:14:12Z","timestamp":1733166852000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Corticosteroid\u2010responsive narcolepsy type\n                    <scp>II<\/scp>\n                    after\n                    <scp>COVID<\/scp>\n                    \u201019: A relevant differential diagnosis of post\u2010\n                    <scp>COVID<\/scp>\n                    syndrome (a case report)"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6007-5114","authenticated-orcid":false,"given":"Erika C. S.","family":"K\u00fcnstler","sequence":"first","affiliation":[{"name":"Department of Neurology Jena University Hospital  Jena Germany"},{"name":"Interdisciplinary Centre for Sleep and Ventilatory Medicine Jena University Hospital  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solveig","family":"Menrad","sequence":"additional","affiliation":[{"name":"Department of Neurology Jena University Hospital  Jena Germany"},{"name":"Interdisciplinary Centre for Sleep and Ventilatory Medicine Jena University Hospital  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Utech","sequence":"additional","affiliation":[{"name":"Department of Neurology Jena University Hospital  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Finke","sequence":"additional","affiliation":[{"name":"Department of Neurology Jena University Hospital  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6291-2721","authenticated-orcid":false,"given":"Sven","family":"Rupprecht","sequence":"additional","affiliation":[{"name":"Department of Neurology Jena University Hospital  Jena Germany"},{"name":"Interdisciplinary Centre for Sleep and Ventilatory Medicine Jena University Hospital  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,2]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"International classification of sleep disorders","author":"American Academy of Sleep Medicine","year":"2014"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0226-9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsy118"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20339"},{"key":"e_1_2_8_6_1","article-title":"A rare case of narcolepsy following SARS\u2010CoV\u20102 infection. 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Sleep gems: Case reports from the world of sleep","volume":"205","author":"Deshpande P.","year":"2022","journal-title":"American Thoracic Society"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsaa044"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/NSS.S275931"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/26.7.809"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2020.1719832"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2869.2003.00380.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.13754"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.8668"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000609"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.12.2253"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.7370"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/NSS.S344299"}],"container-title":["Journal of Sleep Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsr.14406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T02:51:40Z","timestamp":1764903100000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jsr.14406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,2]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1111\/jsr.14406"],"URL":"https:\/\/doi.org\/10.1111\/jsr.14406","archive":["Portico"],"relation":{},"ISSN":["0962-1105","1365-2869"],"issn-type":[{"value":"0962-1105","type":"print"},{"value":"1365-2869","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,2]]},"assertion":[{"value":"2024-06-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14406"}}