{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T05:06:03Z","timestamp":1776229563698,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Central sleep apneas (CSA) can occur de novo at high\u2010altitude in individuals without sleep\u2010disordered breathing at low altitude. These apneas are usually brief, lasting only 5\u201315\u2009s. This report presents the first documented case of a man experiencing extreme altitude\u2010induced CSA lasting more than 100\u2009s in the absence of any sleep breathing disorder in normoxia. A 23\u2010year\u2010old male with no pre\u2010existing health conditions was recruited for a study examining the work of breathing during sleep at a simulated altitude of 3500\u2009m (FiO\n                    <jats:sub>2<\/jats:sub>\n                    :13%). A lowland polysomnography was first conducted to exclude moderate to severe sleep\u2010disordered breathing and showed an apnea\u2013hypopnea index (AHI) of 7.6\/h, an oxygen desaturation index (ODI) of 4.8\/h, and a mean pulse oximetry\u2010based oxygen saturation (SpO\n                    <jats:sub>2<\/jats:sub>\n                    ) of 93.9%. During the recording in the hypoxic chamber, the participant experienced prolonged CSA lasting up to 1\u2009min and 49\u2009s. These apneas were associated with significant oxygen desaturations (nadir: 44%). To investigate the origin of these atypical CSA, the participant underwent a new low\u2010altitude polysomnography with transcutaneous CO\n                    <jats:sub>2<\/jats:sub>\n                    measurement (mean PaCO\n                    <jats:sub>2<\/jats:sub>\n                    :46\u2009mmHg) and diurnal arterial blood gas analysis (pH: 7.42, pCO\n                    <jats:sub>2<\/jats:sub>\n                    : 35.1\u2009mmHg, pO\n                    <jats:sub>2<\/jats:sub>\n                    : 79.9\u2009mmHg, HCO\n                    <jats:sub>3<\/jats:sub>\n                    <jats:sup>\u2212<\/jats:sup>\n                    : 22.4\u2009mmol\/L). These results indicated no signs of chronic hypercapnia or hypocapnia. A hypoxia tolerance test (FiO\n                    <jats:sub>2<\/jats:sub>\n                    : 11.5%) demonstrated a good ventilatory response to hypoxia during exercise (1.004\u2009L\/min\/kg). A rebreathing test according to the Read protocol in hyperoxia demonstrated an impaired ventilatory response to CO\n                    <jats:sub>2<\/jats:sub>\n                    (&lt;0.6\u2009L\/min\/mmHg). This report documents a rare form of extreme hypoxia\u2010induced CSA, potentially caused by impaired CO\n                    <jats:sub>2<\/jats:sub>\n                    chemoreceptor sensitivity and an increased arousal threshold.\n                  <\/jats:p>","DOI":"10.1111\/jsr.14429","type":"journal-article","created":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T18:10:12Z","timestamp":1733076612000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Extreme altitude\u2010induced central sleep apneas lasting more than 100\u2009seconds in a healthy 23\u2010year\u2010old man"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9477-372X","authenticated-orcid":false,"given":"Gr\u00e9gory","family":"Heiniger","sequence":"first","affiliation":[{"name":"Center for Investigation and Research in Sleep Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arton","family":"Peci","sequence":"additional","affiliation":[{"name":"Center for Investigation and Research in Sleep Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola Andrea","family":"Marchi","sequence":"additional","affiliation":[{"name":"Center for Investigation and Research in Sleep Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffroy","family":"Solelhac","sequence":"additional","affiliation":[{"name":"Center for Investigation and Research in Sleep Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Th\u00e9o","family":"Imler","sequence":"additional","affiliation":[{"name":"Center for Investigation and Research in Sleep Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrien","family":"Waeber","sequence":"additional","affiliation":[{"name":"Center for Investigation and Research in Sleep Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Bradley","sequence":"additional","affiliation":[{"name":"Center for Investigation and Research in Sleep Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianpaolo","family":"Lecciso","sequence":"additional","affiliation":[{"name":"Center for Investigation and Research in Sleep Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Wellman","sequence":"additional","affiliation":[{"name":"Division of Sleep and Circadian Disorders Brigham and Women's Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alban","family":"Lovis","sequence":"additional","affiliation":[{"name":"Division of Pneumology, Department of Medicine Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Monney","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Cardio\u2010Vascular Department Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise","family":"Auberson","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Cardio\u2010Vascular Department Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3215-7788","authenticated-orcid":false,"given":"Raphael","family":"Heinzer","sequence":"additional","affiliation":[{"name":"Center for Investigation and Research in Sleep Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2013.05.020"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.6576"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00363.2021"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00070404"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-1770342"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00649.2013"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2014.277210"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-015-1290-z"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(00)00157-2"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(97)00024-8"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP285427"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scispo.2015.10.001"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.185504"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1114\/B:ABME.0000049037.65204.4c"},{"key":"e_1_2_11_16_1","first-page":"5828","article-title":"Ventilatory instability during sleep: New insights from the computational model","volume":"2005","author":"Topor Z. L.","year":"2005","journal-title":"Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00585.2002"}],"container-title":["Journal of Sleep Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsr.14429","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T02:52:43Z","timestamp":1764903163000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jsr.14429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1111\/jsr.14429"],"URL":"https:\/\/doi.org\/10.1111\/jsr.14429","archive":["Portico"],"relation":{},"ISSN":["0962-1105","1365-2869"],"issn-type":[{"value":"0962-1105","type":"print"},{"value":"1365-2869","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"2024-08-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14429"}}