{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T04:57:39Z","timestamp":1764910659328,"version":"3.46.0"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T00:00:00Z","timestamp":1738022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    The neuronal ceroid lipofuscinoses (NCLs) are a group of recessively inherited neurodegenerative diseases characterizsed by lysosomal storage of fluorescent materials. CLN3 disease, or juvenile Batten disease, is the most common NCL that is caused by mutations in the\n                    <jats:italic>Ceroid Lipofuscinosis, Neuronal 3<\/jats:italic>\n                    (\n                    <jats:italic>CLN3<\/jats:italic>\n                    ) gene. Sleep disturbances are among the most common symptoms associated with CLN3 disease that deteriorate the patients' life quality, yet this is understudied and has not been delineated in animal models of the disease. The current study utilised PiezoSleep, a non\u2010invasive, automated piezoelectric motion sensing system, to classify sleep and wakefulness in a\n                    <jats:italic>Cln3<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u0394ex1\u20136\/\u0394ex1\u20106<\/jats:italic>\n                    <\/jats:sup>\n                    (\n                    <jats:italic>Cln3<\/jats:italic>\n                    KO) mouse model and age\u2010 and sex\u2010matched wild\u2010type (WT) controls. The sleep\u2013wake classification by PiezoSleep was found to be about 90% accurate when validated against simultaneous polysomnographic recordings including electroencephalography (EEG) and electromyography (EMG) in a small cohort of WT and\n                    <jats:italic>Cln3<\/jats:italic>\n                    KO mice. Our large cohort PiezoSleep study revealed sleep abnormalities during the light period in male\n                    <jats:italic>Cln3<\/jats:italic>\n                    KO mice compared with WT male mice, and more subtle differences in\n                    <jats:italic>Cln3<\/jats:italic>\n                    KO female mice in the dark period compared with WT female mice. Our characterisation of sleep in the\n                    <jats:italic>Cln3<\/jats:italic>\n                    KO mouse model aligns with sleep abnormalities seen in CLN3 disease patients and serves as a basis to continue examining sleep disturbances commonly reported for CLN3 disease and other NCLs. As the first animal model study capturing sleep disturbances in CLN3 disease, our work will facilitate future studies into the potential mechanism behind sleep disturbances associated with the disease and the potential treatment strategies.\n                  <\/jats:p>","DOI":"10.1111\/jsr.14461","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T07:24:16Z","timestamp":1738049056000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characterisation of sleep in a mouse model of\n                    <scp>CLN3<\/scp>\n                    disease revealed sex\u2010specific sleep disturbances"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4854-1556","authenticated-orcid":false,"given":"Kelby M.","family":"Kane","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences University of Kentucky  Lexington Kentucky 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