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However, these studies were often limited by small sample sizes. In this study, we examine associations between multiple indices of white matter integrity and sleep health in 29,114 UK Biobank participants. Late chronotype, daytime sleepiness, insomnia symptoms and, most extensively, long sleep duration were independently associated with diffusion MRI markers of reduced white matter integrity. Previous findings showing an association between insomnia symptoms and decreased fractional anisotropy (FA) in the anterior internal capsule could not be replicated. To our knowledge, the current analysis is the first study to find an association between long sleep duration and impaired microstructural white matter integrity. Previous assumptions concerning the role of white matter integrity for insomnia are challenged.<\/jats:p>","DOI":"10.1111\/jsr.70034","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T22:30:16Z","timestamp":1741818616000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Sleep Health and White Matter Integrity in the\n                    <scp>UK<\/scp>\n                    Biobank"],"prefix":"10.1111","volume":"34","author":[{"given":"Roxana","family":"Petri","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Medical Centre \u2013 University of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5342-055X","authenticated-orcid":false,"given":"Florian","family":"Holub","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Medical Centre \u2013 University of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9737-9365","authenticated-orcid":false,"given":"Julian E.","family":"Schiel","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Medical Centre \u2013 University of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9436-1258","authenticated-orcid":false,"given":"Bernd","family":"Feige","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Medical Centre \u2013 University of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"},{"name":"Center for Basics in NeuroModulation (NeuroModulBasics), Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin K.","family":"Rutter","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Endocrinology and Gastroenterology, School of Medical Sciences University of Manchester  Manchester UK"},{"name":"Diabetes, Endocrinology and Metabolism Centre, Manchester Royal Infirmary Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5371-9631","authenticated-orcid":false,"given":"Sandra","family":"Tamm","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Psychiatry Oxford University  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1968-6220","authenticated-orcid":false,"given":"Dieter","family":"Riemann","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Medical Centre \u2013 University of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"},{"name":"Center for Basics in NeuroModulation (NeuroModulBasics), Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon D.","family":"Kyle","sequence":"additional","affiliation":[{"name":"Sleep and Circadian Neuroscience Institute (SCNi), Nuffield Department of Clinical Neurosciences University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4133-3464","authenticated-orcid":false,"given":"Kai","family":"Spiegelhalder","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Medical Centre \u2013 University of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.10.034"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","unstructured":"Arora A. 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