{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:53:47Z","timestamp":1791003227076,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003825","name":"Magyar Tudom\u00e1nyos Akad\u00e9mia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Migraine has been linked to chronotype, but with mixed results. Here, we tested chronotype in association with physical and mental health and headache characteristics in a large database of migraine patients and controls. A sample of the UK Biobank (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009360,081; 58.3% female, mean age: 56.38) was used. Data included self\u2010reported chronotype, mental (neuroticism, depression, stress) and physical (body fat percentage, overall health rating) health factors, and migraine diagnosis based on ICD\u201010\u2009G43 diagnosis from healthcare data. Morning type controls (\n                    <jats:italic>C<\/jats:italic>\n                    <jats:sub>morning<\/jats:sub>\n                    ,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009210,775), evening type controls (\n                    <jats:italic>C<\/jats:italic>\n                    <jats:sub>evening<\/jats:sub>\n                    ,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009129,174), morning type migraine patients (\n                    <jats:italic>M<\/jats:italic>\n                    <jats:sub>morning<\/jats:sub>\n                    ,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200912,194), and evening type migraine patients (\n                    <jats:italic>M<\/jats:italic>\n                    <jats:sub>evening<\/jats:sub>\n                    ,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20097938) were compared. Additionally, in a subsample of questionnaire\u2010based migraine (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200915,356), chronotype was tested in association with headache\u2010related features. One\u2010way ANOVA, Kruskal\u2013Wallis test and chi\u2010squared test were run in SPSS 28 with Bonferroni correction. Evening chronotype was more frequent among migraine patients with an OR\u2009=\u20091.06, 95% CI [1.03; 1.09] compared to controls (\n                    <jats:italic>\u03c7<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u200916.523,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). The\n                    <jats:italic>M<\/jats:italic>\n                    <jats:sub>evening<\/jats:sub>\n                    group showed the worst level of all mental and physical health variables, while the\n                    <jats:italic>C<\/jats:italic>\n                    <jats:sub>morning<\/jats:sub>\n                    group reported the best values. Migraine patients with morning or evening chronotype showed a highly similar headache symptom profile, but the\n                    <jats:italic>M<\/jats:italic>\n                    <jats:sub>evening<\/jats:sub>\n                    subgroup expressed a higher disability (\n                    <jats:italic>t<\/jats:italic>\n                    \u2009=\u2009\u22123.965,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). In conclusion, evening chronotype was associated with the worst physical and mental health status and the highest headache\u2010related disability among migraine patients, suggesting a need for elevated medical attention on chronotype in migraine.\n                  <\/jats:p>","DOI":"10.1111\/jsr.70066","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T03:18:51Z","timestamp":1744255131000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Evening Chronotype Associates With Worse Physical and Mental Health and Headache\u2010Related Disability Among Migraine Patients"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7826-9179","authenticated-orcid":false,"given":"Daniel","family":"Baksa","sequence":"first","affiliation":[{"name":"Department of Pharmacodynamics, Faculty of Pharmaceutical Sciences Semmelweis University  Budapest 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Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9213-4345","authenticated-orcid":false,"given":"Dora","family":"Torok","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics, Faculty of Pharmaceutical Sciences Semmelweis University  Budapest Hungary"},{"name":"NAP3.0\u2010SE Neuropsychopharmacology Research Group, Hungarian Brain Research Program Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4765-2351","authenticated-orcid":false,"given":"Gabor","family":"Hullam","sequence":"additional","affiliation":[{"name":"Department of Measurement and Information Systems Budapest University of Technology and Economics  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8141-3410","authenticated-orcid":false,"given":"Gyorgy","family":"Bagdy","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics, Faculty of Pharmaceutical Sciences Semmelweis University  Budapest Hungary"},{"name":"NAP3.0\u2010SE Neuropsychopharmacology Research Group, Hungarian Brain Research Program Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5975-4267","authenticated-orcid":false,"given":"Gabriella","family":"Juhasz","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics, Faculty of Pharmaceutical Sciences Semmelweis University  Budapest Hungary"},{"name":"NAP3.0\u2010SE Neuropsychopharmacology Research Group, Hungarian Brain Research Program Semmelweis University  Budapest 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