{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:03:21Z","timestamp":1790193801086,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,20]],"date-time":"2025-04-20T00:00:00Z","timestamp":1745107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In an unselected obstructive sleep apnoea (OSA) population, continuous positive airway pressure (CPAP) slightly lowers blood pressure (BP). The aim was to investigate the differential effects of CPAP on BP in different OSA severities. Medline was searched through December 2023 for randomised controlled trials (RCTs) on the effect of CPAP compared to an inactive control on office, 24\u2009h, diurnal and nocturnal systolic and diastolic BP in OSA. A random\u2010effects meta\u2010analysis was performed at the study level for the different BP measures; meta\u2010regression and subgroup analyses were used to examine the effects of OSA characteristics and CPAP use. Seventy\u2010five RCTs (10,025 patients) were included. CPAP lowered office, 24\u2009h, diurnal and nocturnal systolic BP (SBP) by \u22122.5 (95% CI \u22123.8 to \u22121.2; nRCTs\u2009=\u200940), \u22122.6 (95% CI \u22123.6 to \u22121.6;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200929), \u22122.2 (95% CI \u22123.2 to \u22121.3;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200932) and\u2009\u2212\u20093.5 (95% CI \u22124.4 to \u22122.5;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200932) mmHg, respectively. In the meta\u2010regressions, higher 24\u2009h and diurnal SBP and longer nocturnal CPAP use were significantly associated with greater BP reduction (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). In subgroup analyses, the reduction in 24\u2009h, diurnal, and nocturnal SBP was greater in studies with an apnoea\u2010hypopnoea index\u2009\u2265\u200930\/h compared to mild OSA. CPAP use \u2265\u20095\u2009h\/night had a greater impact on lowering 24\u2009h and nocturnal SBP (\u22124.2 vs. \u22122.1,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.05, and \u22124.2 vs. \u22121.6\u2009mmHg,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.01). CPAP has the strongest BP\u2010lowering effect on nocturnal blood pressure, which is, particularly, relevant prognostically and the effect is stronger at higher baseline BP and with CPAP use of \u2265\u20095\u2009h.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Study Registration:<\/jats:bold>\n                    The systematic review and meta\u2010analysis has been registered on PROSPERO: CRD42023477227.\n                  <\/jats:p>","DOI":"10.1111\/jsr.70072","type":"journal-article","created":{"date-parts":[[2025,4,20]],"date-time":"2025-04-20T22:54:31Z","timestamp":1745189671000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effects of\n                    <scp>CPAP<\/scp>\n                    on Blood Pressure Parameter Across Different Severities of Obstructive Sleep Apnoea: A Meta\u2010Analysis"],"prefix":"10.1111","volume":"34","author":[{"given":"Lara","family":"Benning","sequence":"first","affiliation":[{"name":"Department of Pulmonology and Sleep Disorders Centre University Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00ebl J.","family":"Herzig","sequence":"additional","affiliation":[{"name":"Department of Pulmonology and Sleep Disorders Centre University Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle S.","family":"Mollet","sequence":"additional","affiliation":[{"name":"Department of Pulmonology and Sleep Disorders Centre University Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Bradicich","sequence":"additional","affiliation":[{"name":"Department of Pulmonology and Sleep Disorders Centre University Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martino F.","family":"Pengo","sequence":"additional","affiliation":[{"name":"Istituto Auxologico Italiano IRCCS  Milan Italy"},{"name":"Department of Medicine and Surgery University of Milano\u2010Bicocca  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Ulrich","sequence":"additional","affiliation":[{"name":"Department of Pulmonology and Sleep Disorders Centre University Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8840-981X","authenticated-orcid":false,"given":"Esther I.","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Department of Pulmonology and Sleep Disorders Centre University Hospital Zurich  Zurich Switzerland"},{"name":"Centre of Competence Sleep &amp; Health Zurich University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.20f13681"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(21)01921\u20108"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(07)61538\u20104"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl\u20102013\u2010204993"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.154.5.8912770"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00651\u20102017"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2012.02.005"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2015.09.002"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000170138.56903.7a"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.171553"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resinv.2024.05.004"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.049730"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2021.101446"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0895\u20107061(01)02143\u20104"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0962280216669183"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000003480"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.281250"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.2170"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(22)00172\u20103"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.14.1829"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n160"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.179788"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01945\u20102019"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005113421901"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.17465"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1429"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118235"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00204209"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1356"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/30.6.711"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.9811"}],"container-title":["Journal of Sleep Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsr.70072","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T13:58:32Z","timestamp":1764597512000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jsr.70072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,20]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/jsr.70072"],"URL":"https:\/\/doi.org\/10.1111\/jsr.70072","archive":["Portico"],"relation":{},"ISSN":["0962-1105","1365-2869"],"issn-type":[{"value":"0962-1105","type":"print"},{"value":"1365-2869","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,20]]},"assertion":[{"value":"2024-12-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70072"}}