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Ancient civilisations used their understanding of the sedative nature of natural herbs and compounds to induce sleep. The discovery of barbiturates and bromides heralded a new era of synthetic sleep medicine in the 19th century. This was followed by the development of benzodiazepines that were used to inhibit signalling throughout the brain by promoting gamma\u2010amino butyric acid release and thereby produce loss of consciousness. As our understanding of sleep has deepened, newer therapies have more specifically targeted the wake\u2010inducing neurotransmitter orexin with fewer side effects. Given the newly highlighted role of kinases in sleep\/wake regulation, we predict that the next breakthroughs in sleep medicine will likely target these kinases. Given the fundamental role that sleep plays in maintaining brain health through processes such as glymphatic clearance, sleep medicine has therapeutic potential beyond just sleep. Recent evidence suggests that sleep disruptions directly contribute to the build\u2010up of pathological neuronal proteins in neurodegenerative disorders. Therefore, sleep medicine could improve prognosis in disorders such as these. Great attention must be paid to the mechanism of action of each sleep medicine, however, as sleep medicines which do not fully mimic sleep could actually worsen disease progression.<\/jats:p>","DOI":"10.1111\/jsr.70087","type":"journal-article","created":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T04:19:16Z","timestamp":1746850756000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Dreaming of Better Treatments: Advances in Drug Development for Sleep Medicine and Chronotherapy"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9858-3625","authenticated-orcid":false,"given":"Brooke A.","family":"Prakash","sequence":"first","affiliation":[{"name":"Department of Pharmacology University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishani","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Pharmacology University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohao","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Pharmacology University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sridhar","family":"Vasudevan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2132-8200","authenticated-orcid":false,"given":"Aarti","family":"Jagannath","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences, Sleep and Circadian Neuroscience Institute (SCNi) University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell G.","family":"Foster","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences, Sleep and Circadian Neuroscience Institute (SCNi) University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,10]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.4324\/9781315071558"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/medhum-2019-011683"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881115581963"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102826.2005.01333.x"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2004.05.002"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23020729"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.yco.0000165594.60434.84"},{"key":"e_1_2_14_9_1","first-page":"1","volume-title":"Atlas of Sleep Medicine","author":"Bonnema S. 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