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The purpose of this cross\u2010sectional study was to determine the association between sleep characteristics and A\u03b2 burden using polysomnography and positron emission tomography (PET). Cognitively normal older adults (ages 60\u201385) with symptoms of insomnia underwent PET and overnight polysomnography. Pearson correlations determined the association between sleep variables and the standard uptake values ratio (SUVR) within global cerebral cortex, precuneus, posterior cingulate cortex (PCC), and the medial prefrontal cortex (mPFC). Multivariable stepwise regression was performed for each region of interest with apolipoprotein\u2010\u03b5 (APOE) genotype and age as potential covariates. Sleep parameters between those who were A\u03b2 elevated vs. non\u2010elevated were compared using\n                    <jats:italic>t<\/jats:italic>\n                    \u2010tests. Forty\u2010three adults (69.3\u2009\u00b1\u20095.5\u2009years old; 32.6% A\u03b2 elevated; mostly non\u2010Hispanic white and female) were included in analyses. Longer stage 1 was related to greater cortical and mPFC SUVR, greater wake after sleep onset was related to greater cortical, mPFC, and precuneus SUVR, and shorter stage 2 was associated with greater PCC SUVR. Compared to those who were A\u03b2 non\u2010elevated, those who were A\u03b2 elevated had longer stage 1 and shorter stage 2 sleep. Greater sleep fragmentation, longer stage 1 sleep, and shorter stage 2 sleep were associated with greater A\u03b2 burden in various regions of the brain in cognitively normal older adults. The results support poor sleep as an early risk factor for A\u03b2 accumulation and possible target for Alzheimer's prevention.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    The study was registered on\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link>\n                    (NCT03954210).\n                  <\/jats:p>","DOI":"10.1111\/jsr.70098","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T11:24:56Z","timestamp":1749727496000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Sleep Fragmentation and Sleep Stages 1 and 2 Are Associated With Amyloid\u2010Beta Burden in Cognitively Normal Older 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University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eryen","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Rehabilitation Science, and Athletic Training University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1910-7784","authenticated-orcid":false,"given":"Allison","family":"Glaser","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Rehabilitation Science, and Athletic Training University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Drerup","sequence":"additional","affiliation":[{"name":"Sleep Disorders Center Neurological Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milind A.","family":"Phadnis","sequence":"additional","affiliation":[{"name":"Department of Biostatistics &amp; Data Science University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared","family":"Bruce","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Health Informatics School of Medicine, University of Missouri\u2010Kansas City  Kansas City Missouri USA"},{"name":"Department of Neurology and Psychiatry University Health  Kansas City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Burns","sequence":"additional","affiliation":[{"name":"University of Kansas Alzheimer's Disease Research Center  Fairway Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine F.","family":"Siengsukon","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Rehabilitation Science, and Athletic Training University 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