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This investigation aimed to detect clinically distinct age of insomnia onset subgroups utilising latent profile analysis (LPA). Participants were 618 adults, aged 18\u201371\u2009years (\n                    <jats:italic>M<\/jats:italic>\n                    \u2009=\u200928.94, SD\u2009=\u200911.06), with insomnia. Participants completed a survey assessing insomnia natural history and causal attributions; sleep disturbance and impairment; pre\u2010sleep arousal and threat monitoring; stress, mental and physical health; and social functioning. LPA was performed on age of insomnia onset. Binary logistic regression analyses were performed to evaluate associations between clinical measures and early versus late onset insomnia with statistical adjustment for chronological age and sex. Results showed a two\u2010class model (Class 1:\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009547, 88.5%,\n                    <jats:italic>M<\/jats:italic>\n                    <jats:sub>onset<\/jats:sub>\n                    \u2009=\u200919.21\u2009years, range\u2009=\u20090\u201334\u2009years; Class 2:\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200971, 11.5%,\n                    <jats:italic>M<\/jats:italic>\n                    <jats:sub>onset<\/jats:sub>\n                    \u2009=\u200943.49\u2009years, range\u2009=\u200935\u201368\u2009years) was optimal for forming insomnia age of onset subgroups. Bodily arousal and developmental (e.g., childhood experiences, traumatic events) contributors to insomnia onset, greater overall and cognitive pre\u2010sleep arousal, later bedtime and rise time, greater depressive symptoms, and endorsement of lifetime major depressive disorder, migraine, and arthritis were significant indicators of early onset insomnia subgroup membership. Hormonal contributors (e.g., ageing, menopause) to insomnia onset and maintenance, and more positive global mental health were significant indicators of late onset insomnia subgroup membership. Findings suggest the relevance of mindfulness\u2010based, acceptance\u2010based, and trauma\u2010focused adaptations of cognitive\u2010behavioural therapy for early onset insomnia, and management of ageing\u2010related hormonal changes for late onset insomnia.\n                  <\/jats:p>","DOI":"10.1111\/jsr.70103","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T08:30:12Z","timestamp":1750667412000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Age of Onset in Insomnia: A Latent Profile Analysis"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1633-8618","authenticated-orcid":false,"given":"Emily J.","family":"Ricketts","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Biobehavioral Sciences University of California, Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Kircanski","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6407-4653","authenticated-orcid":false,"given":"Daniel S.","family":"Joyce","sequence":"additional","affiliation":[{"name":"School of Psychology &amp; Wellbeing University of Southern Queensland\u2010Ipswich  Ipswich Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel J.","family":"Rissman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Biobehavioral Sciences University of California, Los Angeles  Los Angeles California USA"},{"name":"Gordon F. Derner School of Psychology Adelphi University  Garden City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliet","family":"Ottenberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Biobehavioral Sciences University of California, Los Angeles  Los Angeles California USA"},{"name":"School of Global Public Health New York University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3172-1815","authenticated-orcid":false,"given":"Adriane M.","family":"Soehner","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2021.03.028"},{"key":"e_1_2_9_3_1","first-page":"267","volume-title":"2nd International Symposium on Information Theory","author":"Akaike H.","year":"1973"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291713000470"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/NSS.S125807"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/15402002.2020.1826484"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15402010bsm0201_5"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleepadvances\/zpac018"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-08518-5_11"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3758\/s13428\u2010011\u20100081\u20100"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2016.10.005"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215\u20100366(18)30464\u20104"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/15402002.2022.2109640"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2025.106489"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-016-1072-9"},{"key":"e_1_2_9_16_1","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen J.","year":"1988"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.08.016"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0033291704003253"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.13928"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.64"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsab095"},{"key":"e_1_2_9_22_1","first-page":"1","article-title":"Sleep and Inflammation: A Bidirectional Relationship","volume":"29","author":"Engert L. 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