{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:27:38Z","timestamp":1788881258642,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cognitive processes commonly affected by obstructive sleep apnea (OSA) are more strongly associated with hypoxic load parameters than the apnea\u2010hypopnea index (AHI). Additionally, lower SpO\n                    <jats:sub>2<\/jats:sub>\n                    during wake affects cognition, emphasising the need for concurrent assessment with sleep SpO\n                    <jats:sub>2<\/jats:sub>\n                    . This study examined which OSA severity parameters best predict cognitive performance and the role of wake SpO\n                    <jats:sub>2<\/jats:sub>\n                    . Sixty\u2010one participants (53% female), with an average age of 46.9\u2009years (range 19\u201379), completed a three\u2010night self\u2010applied polysomnography (PSG) and a digital neurocognitive battery. Oxygen saturation\u2010based PSG parameters predicted immediate recall, vigilance, and processing speed, whereas the AHI did not. Greater hypoxic severity from 100% SpO\n                    <jats:sub>2<\/jats:sub>\n                    baseline was the strongest predictor of slower processing speed (\n                    <jats:italic>\u03c7<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    (6)\u2009=\u200917.74,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.007) (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u2009\u22125.72,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.023). Lower average SpO\n                    <jats:sub>2<\/jats:sub>\n                    during sleep most strongly predicted immediate recall (\n                    <jats:italic>\u03c7<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    (6)\u2009=\u200928.94,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u20090.38,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03) and vigilance (\n                    <jats:italic>\u03c7<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    (6)\u2009=\u200916.72,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.010) (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u20090.15,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002). Additionally, lower wake SpO\n                    <jats:sub>2<\/jats:sub>\n                    was associated with reduced vigilance performance. The results confirm the AHI's limitation in capturing OSA symptom severity and highlight the stronger associations between oxygen saturation\u2010based OSA parameters and cognitive abilities. Furthermore, we recommend incorporating wake SpO\n                    <jats:sub>2<\/jats:sub>\n                    measures in sleep research to gain a more comprehensive understanding of the relationship between SpO\n                    <jats:sub>2<\/jats:sub>\n                    and cognitive abilities.\n                  <\/jats:p>","DOI":"10.1111\/jsr.70136","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T22:38:20Z","timestamp":1751582300000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Hypoxic Load and Average Oxygen\u2010Saturation During Sleep and Wake Are Associated With Cognitive Function in Obstructive Sleep Apnea"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4310-1547","authenticated-orcid":false,"given":"K.","family":"Thorisdottir","sequence":"first","affiliation":[{"name":"Reykjavik University Sleep Institute, School of Technology Reykjavik University  Reykjavik Iceland"},{"name":"Department of Psychology Reykjavik University  Reykjavik Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4017-821X","authenticated-orcid":false,"given":"T.","family":"Lepp\u00e4nen","sequence":"additional","affiliation":[{"name":"Department of Technical Physics University of Eastern Finland  Kuopio Finland"},{"name":"Diagnostic Imaging Center Kuopio University Hospital  Kuopio Finland"},{"name":"School of Electrical Engineering and Computer Science The University of Queensland  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Hrubos\u2010Str\u00f8m","sequence":"additional","affiliation":[{"name":"Akershus University Hospital  Akershus Norway"},{"name":"Institute of Clinical Medicine, University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0919-4879","authenticated-orcid":false,"given":"E.","family":"Richert","sequence":"additional","affiliation":[{"name":"Reykjavik University Sleep Institute, School of Technology Reykjavik University  Reykjavik Iceland"},{"name":"Department of Psychology Reykjavik University  Reykjavik Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Biedebach","sequence":"additional","affiliation":[{"name":"Reykjavik University Sleep Institute, School of Technology Reykjavik University  Reykjavik Iceland"},{"name":"Department of Computer Science Reykjavik University  Reykjavik Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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