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This investigation aimed to explore the effect of ferroptosis on OSAHS\u2010hypertension. Ferroptosis\u2010associated genes were screened based on the GSE205050 dataset and FerrDb database. An OSAHS\u2010hypertension model was established by exposing Sprague Dawley rats to chronic intermittent hypoxia for 8\u2009weeks, and human umbilical vein endothelial cells (HUVECs) were exposed to intermittent hypoxia in\u00a0vitro. CDC25A was overexpressed using recombinant adeno\u2010associated virus in\u00a0vivo and plasmid transfection in\u00a0vitro. Ferroptosis markers, oxidative stress indicators, blood pressure, abdominal aortic tissue histopathology, and endothelial cell viability\/apoptosis were then assessed. Six ferroptosis\u2010associated hub genes were identified, including CDC25A, EZH2, PARP1, HELLS, FANCD2, and RRM2, all of which were lowly expressed. In the rat model of OSAHS\u2010hypertension, overexpression of CDC25A significantly reduced systolic and diastolic blood pressure as well as vascular wall thickness, while increasing \u03b1\u2010SMA expression. Biochemical analyses showed that CDC25A decreased malondialdehyde (MDA) and Fe\n                    <jats:sup>2+<\/jats:sup>\n                    levels while increasing glutathione (GSH), superoxide dismutase (SOD), and ferroptosis\u2010associated proteins (FTH1, SLC7A11, GPX4). CDC25A overexpression in HUVECs ameliorated hypoxia\u2010induced endothelial dysfunction by inhibiting ferroptosis and apoptosis and promoting cell survival; however, these protective effects were significantly abrogated by co\u2010treatment with erastin. CDC25A inhibits OSAHS\u2010hypertension progression and modulates ferroptosis\u2010related pathways. This study identifies ferroptosis as a potential therapeutic target in OSAHS\u2010associated hypertension, with CDC25A acting as a key regulatory factor.\n                  <\/jats:p>","DOI":"10.1111\/jsr.70155","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T04:08:41Z","timestamp":1753243721000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>CDC25A<\/scp>\n                    Alleviates Obstructive Sleep Apnea\u2010Hypopnea Syndrome With Hypertension and Inhibits Ferroptosis"],"prefix":"10.1111","volume":"35","author":[{"given":"Xin","family":"Yang","sequence":"first","affiliation":[{"name":"Department of General Practice The First Affiliated Hospital, Guangzhou Medical University  Guangzhou City Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunsheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Practice The First Affiliated Hospital, Guangzhou Medical University  Guangzhou City Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deng","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second People's Hospital of Baiyun Guangzhou  Guangzhou City Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haofeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of General Practice The First Affiliated Hospital, Guangzhou Medical University  Guangzhou City Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhile","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Geriatrics The First Affiliated Hospital, Guangzhou Medical University  Guangzhou City Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HuiLing","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of General Practice The First Affiliated Hospital, Guangzhou Medical University  Guangzhou City Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9490-4785","authenticated-orcid":false,"given":"Ping","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of General Practice The First Affiliated Hospital, Guangzhou Medical University  Guangzhou City Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2020.01.003"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00672.2019"},{"key":"e_1_2_12_4_1","doi-asserted-by":"crossref","first-page":"D991","DOI":"10.1093\/nar\/gks1193","article-title":"NCBI GEO: Archive for Functional Genomics Data Sets\u2013Update","volume":"41","author":"Barrett T.","year":"2013","journal-title":"Nucleic Acids Research"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(19)30198-5"},{"key":"e_1_2_12_6_1","doi-asserted-by":"crossref","unstructured":"Bo W. 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