{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:26:12Z","timestamp":1792452372886,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T00:00:00Z","timestamp":1754352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T00:00:00Z","timestamp":1754352000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This scoping review aims to synthesise prevailing scientific evidence on the sleep\u2010related manifestations of anti\u2010IgLON5 disease to identify distinctive sleep and\/or polysomnographic patterns which may facilitate diagnosis. A systematic search was conducted to identify studies from 2014 to 2023 which included patients with sleep disturbances and immunohistochemically\u2010proven anti\u2010IgLON5 disease. Eligible studies included clinical trials, observational studies, and case series that contained descriptions of their sleep disturbances and\/or polysomnographic features. Data on their clinical features, polysomnographic findings, and non\u2010sleep\u2010related symptoms were extracted and analysed. 55 cases from eight reports were analysed. Median age at onset was 61.8\u2009years, with a 2\u2010year median delay to diagnosis. Sleep apnea (97.4%), parasomnia (61.5%), insomnia (41.0%), and daytime sleepiness (41.0%) were the most prevalent disturbances, of which two\u2010thirds exhibited multiple sleep disorders within the same patient. Most patients had co\u2010existing non\u2010sleep\u2010related features at the initial stages of evaluation, such as bulbar dysfunction (80%), dysautonomia (50.9%), and cognitive impairment (45.5%). Polysomnography (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200926) mostly showed the non\u2010specific features of reduced total sleep time, low sleep efficiency, increased arousal index, and elevated apnea\u2010hypopnea index in affected patients. Diagnosis of anti\u2010IgLON5 disease remains challenging. The diagnostic significance of undifferentiated non\u2010rapid eye movement and poorly\u2010structured N2 remains unproven. Polysomnographic anomalies were often non\u2010specific, and their evolution as with disease progression was difficult to discern without longitudinal polysomnography data. Regardless, anti\u2010IgLON5 disease should be strongly considered in patients with multiple sleep disorders and the above\u2010mentioned polysomnographic abnormalities, especially when accompanied by neurological anomalies.\n                  <\/jats:p>","DOI":"10.1111\/jsr.70159","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T06:53:36Z","timestamp":1754463216000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Review of the Clinical and Polysomnographic Features of Sleep Disturbances in Patients With Anti\u2010\n                    <scp>IgLON5<\/scp>\n                    Disease"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0091-5599","authenticated-orcid":false,"given":"You\u2010Jiang","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Neurology National Neuroscience Institute, Singapore General Hospital Campus  Singapore Singapore"},{"name":"SingHealth Duke\u2010NUS Sleep Centre  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tushar","family":"Gosavi","sequence":"additional","affiliation":[{"name":"Department of Neurology National Neuroscience Institute, Singapore General Hospital Campus  Singapore Singapore"},{"name":"SingHealth Duke\u2010NUS Sleep Centre  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wai\u2010dic","family":"Foong","sequence":"additional","affiliation":[{"name":"Department of Neurology National Neuroscience Institute, Singapore General Hospital Campus  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,5]]},"reference":[{"issue":"4","key":"e_1_2_9_2_1","first-page":"557","article-title":"Clinical \u201cCase Series\u201d: A Concept Analysis","volume":"12","author":"Abu\u2010Zidan F. 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