{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:54:53Z","timestamp":1787068493929,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T00:00:00Z","timestamp":1758326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T00:00:00Z","timestamp":1758326400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    While Zepbound (Tirzepetide) is the only FDA\u2010approved drug for obstructive sleep apnea (OSA), pharmacological options remain limited. Emerging data suggest sodium glucose co\u2010transporter (SGLT\u20102) inhibitors may offer a novel therapeutic benefit in this population. Our meta\u2010analysis aims to evaluate their efficacy based on current evidence. PubMed and Google Scholar were searched from inception to September 2024 for Randomised Controlled Trials (RCTs) and observational studies comparing SGLT\u20102 inhibitors to placebo in patients with OSA using continuous positive airway pressure (CPAP). After careful screening, 4 studies involving 686 patients were analysed using the random\u2010effects model in RevMan 5.4.1, and mean differences (MD) were calculated. The addition of an SGLT\u20102 inhibitor showed a statistically significant reduction in the apnea\u2010hypopnea index (AHI) [MD\u2009=\u2009\u22125.52 (95% CI: \u22129.72 to \u22121.32) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.01)], oxygen desaturation index [MD\u2009=\u2009\u22123.16 (95% CI: \u22125.33 to \u22120.99) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.004)], and Body Mass Index (BMI) [MD\u2009=\u2009\u22121.29 (95% CI: \u22122.20 to \u22120.39) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.005)]. However, they failed to show any significant improvement in daytime sleepiness [MD\u2009=\u2009\u22122.28 (95% CI: \u22124.92 to 0.37) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.90)] and Haemoglobin A1c [MD\u2009=\u20090.25 (95% CI: \u22120.32 to 0.82) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.88)]. Similarly, SGLT\u20102 inhibitors failed to depict any significant improvement in blood pressure or serum lipid levels. SGLT\u20102 inhibitors, along with significantly reducing AHI, also offer added cardiometabolic benefits in OSA patients. These findings support their role as a promising adjunct or alternative to existing therapeutic options. Further studies are warranted to define their place in OSA management.\n                  <\/jats:p>","DOI":"10.1111\/jsr.70196","type":"journal-article","created":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T07:44:46Z","timestamp":1758354286000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluating the Efficacy of Sodium Glucose Cotransporter\u20102 Inhibitors in Management of Obstructive Sleep Apnea; a Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4753-3591","authenticated-orcid":false,"given":"Sana","family":"Murtaza","sequence":"first","affiliation":[{"name":"Department of Medicine Punjab Medical College  Faisalabad Punjab Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8526-4502","authenticated-orcid":false,"given":"Rohab","family":"Sohail","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Bayhealth Medical Center  Delaware USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bisma","family":"Akram","sequence":"additional","affiliation":[{"name":"Department of Medicine King Edward Medical University  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameen","family":"Tahira","sequence":"additional","affiliation":[{"name":"Department of Medicine Allama Iqbal Medical College  Lahore Punjab Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3551-0046","authenticated-orcid":false,"given":"Maham","family":"Zaman","sequence":"additional","affiliation":[{"name":"Department of Medicine Quaid\u2010e\u2010Azam Medical College  Bahawalpur Punjab Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Nazeer","family":"Mehmood","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Pulmonary\/Critical Care Bayhealth Medical Center  Delaware USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,20]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12050937"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(19)30198-5"},{"issue":"17","key":"e_1_2_13_4_1","first-page":"1840","article-title":"Sleep Apnea and Cardiovascular Disease: Lessons From Recent Trials and Need for Team Science","volume":"128","author":"Drager L. 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T.Higgins.2020. \u201cRisk\u2010Of\u2010Bias VISualization (Robvis): An R Package and Shiny Web App for Visualizing Risk\u2010Of\u2010Bias Assessments.\u201d12 no.1:55\u201361.","DOI":"10.1002\/jrsm.1411"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573399813666170816142351"},{"issue":"2","key":"e_1_2_13_21_1","first-page":"123","article-title":"Clinical Outcomes of Chronic Heart Failure Patients With Unsuppressed Sleep Apnea by Positive Airway Pressure Therapy","volume":"81","author":"Naito R.","year":"2023","journal-title":"Frontiers in Cardiovascular Medicine"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-1096"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.5114\/amsad\/161170"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.7640"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws342"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ17-0440"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)92140-1"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41387-019-0098-5"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-022-02606-1"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.245159"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-0517"},{"key":"e_1_2_13_33_1","first-page":"318","article-title":"Efficacy of Dapagliflozin in the Treatment of HFrEF With Obstructive Sleep Apnea Syndrome (DAHOS Study): Study Protocol for a Multicentric, Prospective, Randomized Controlled Clinical Trial","volume":"24","author":"Xie L.","year":"2023","journal-title":"BMC"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2109080"},{"key":"e_1_2_13_35_1","first-page":"373","article-title":"Empagliflozin, Cardiovascular Outcomes and Mortality in Type 2 Diabetes","volume":"22","author":"Zinman B.","year":"2015","journal-title":"New England Journal of Medicine"}],"container-title":["Journal of Sleep Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsr.70196","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jsr.70196","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsr.70196","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T06:06:08Z","timestamp":1779257168000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jsr.70196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,20]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/jsr.70196"],"URL":"https:\/\/doi.org\/10.1111\/jsr.70196","archive":["Portico"],"relation":{},"ISSN":["0962-1105","1365-2869"],"issn-type":[{"value":"0962-1105","type":"print"},{"value":"1365-2869","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,20]]},"assertion":[{"value":"2025-05-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70196"}}