{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:07:11Z","timestamp":1791216431759,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["PI19\/00875"],"award-info":[{"award-number":["PI19\/00875"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["PI11\/00495"],"award-info":[{"award-number":["PI11\/00495"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007509","name":"Sociedad Espa\u00f1ola de Neumolog\u00eda y Cirug\u00eda Tor\u00e1cica","doi-asserted-by":"publisher","award":["2020\u2010820"],"award-info":[{"award-number":["2020\u2010820"]}],"id":[{"id":"10.13039\/501100007509","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2026,6]]},"abstract":"ABSTRACT<\/jats:title>\n \n The prevalence of obstructive sleep apnea (\n OSA<\/jats:styled-content>\n ) increases during pregnancy and is associated with gestational diabetes mellitus (\n GDM<\/jats:styled-content>\n ), although its clinical impact on birth outcomes remains unclear. We aimed to assess the effect of several\n OSA<\/jats:styled-content>\n criteria and intermittent hypoxia in the third trimester on perinatal outcomes in women with\n GDM<\/jats:styled-content>\n . In this prospective study, polysomnography was performed on 89 women with\n GDM<\/jats:styled-content>\n . Insulin resistance indices (\n HOMA<\/jats:styled-content>\n \u2010\n IR<\/jats:styled-content>\n \/\n QUICKI<\/jats:styled-content>\n ) were calculated, and biomarkers (insulin\u2010like growth factor\u20101 (\n IGF<\/jats:styled-content>\n \u20101), resistin, soluble endoglobulin, galectin\u20103, and free fatty acids) were analysed from women and some cord blood samples using enzyme\u2010linked immunosorbent assay. Whereas\n OSA<\/jats:styled-content>\n did not significantly affect overall perinatal outcomes, specific\n OSA<\/jats:styled-content>\n features\u2014including\n REM<\/jats:styled-content>\n \u2010\n OSA<\/jats:styled-content>\n , supine\u2010position\n OSA<\/jats:styled-content>\n , and an oxygen desaturation index (\n ODI<\/jats:styled-content>\n )\u2009\u2265\u20091\u2009h\n \u22121<\/jats:sup>\n \u2014were linked to adverse effects on neonatal birthweight and length. Moreover, apnea duration was an independent predictor of birthweight, while insulin resistance was more impaired in women with\n OSA<\/jats:styled-content>\n and showed an inverse relationship with sleep and\n REM<\/jats:styled-content>\n time, respectively.\n IGF<\/jats:styled-content>\n \u20101 was elevated and demonstrated a significant predictive value for\n OSA<\/jats:styled-content>\n , as indicated by the\n AUC<\/jats:styled-content>\n \u2013\n ROC<\/jats:styled-content>\n curve. In summary, although\n OSA<\/jats:styled-content>\n did not adversely affect overall perinatal outcomes in women with\n GDM<\/jats:styled-content>\n , specific\n OSA<\/jats:styled-content>\n characteristics were associated with adverse neonatal growth metrics. Insulin resistance was higher in women with\n OSA<\/jats:styled-content>\n , and\n IGF<\/jats:styled-content>\n \u20101 may serve as a potential biomarker for\n OSA<\/jats:styled-content>\n in this population. Further prospective studies with attention to\n REM<\/jats:styled-content>\n \u2010stage, supine\u2010position\n OSA<\/jats:styled-content>\n , apnea duration, and hypoxic burden are needed to elucidate the complex interactions between\n OSA<\/jats:styled-content>\n ,\n GDM<\/jats:styled-content>\n , and fetal outcomes.\n <\/jats:p>","DOI":"10.1111\/jsr.70204","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T11:33:30Z","timestamp":1758195210000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Influence of Obstructive Sleep Apnea on Maternal and Perinatal Outcomes in Patients With Gestational Diabetes Mellitus"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7029-5276","authenticated-orcid":false,"given":"Mar\u00eda Cerd\u00e0","family":"Moncadas","sequence":"first","affiliation":[{"name":"Health Research Institute of the Balearic Islands 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