{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T03:47:01Z","timestamp":1775274421423,"version":"3.50.1"},"reference-count":82,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:00:00Z","timestamp":1759449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Restless legs syndrome (RLS) is a common sensorimotor disorder, and the most common sleep\u2010related movement disorder with a prevalence of up to 15% in the European and US population. This review addresses key aspects of RLS, focusing on novel data that have or will likely have an impact on clinical practice. These include novel insights into pathophysiology and motor activity during sleep, with a key focus on implications for RLS treatment. Along this line, we discuss the problem of augmentation before introducing new treatment paradigms and insights into new drug targets from genetics. Besides RLS, restless sleep disorder, neck myoclonus, fragmentary myoclonus, propriospinal myoclonus at the wake\u2013sleep transition, and facio\u2010mandibular myoclonus are discussed. This review provides an overview of the most recent insights into sleep\u2010related movement disorders, and of how they are changing clinical practice.<\/jats:p>","DOI":"10.1111\/jsr.70210","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T10:31:16Z","timestamp":1759487476000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sleep Related Movement Disorders: What's New and Changing Clinical Practice"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4259-8824","authenticated-orcid":false,"given":"Ambra","family":"Stefani","sequence":"first","affiliation":[{"name":"Medical University Innsbruck  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Tang","sequence":"additional","affiliation":[{"name":"Medical University Innsbruck  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2616-0558","authenticated-orcid":false,"given":"Stefan","family":"Clemens","sequence":"additional","affiliation":[{"name":"East Carolina University  Greenville North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3349-8426","authenticated-orcid":false,"given":"Lourdes M.","family":"DelRosso","sequence":"additional","affiliation":[{"name":"University of California San Francisco  Fresno California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Garcia\u2010Borreguero","sequence":"additional","affiliation":[{"name":"Sleep Research Institute  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6937-3065","authenticated-orcid":false,"given":"Raffaele","family":"Ferri","sequence":"additional","affiliation":[{"name":"Sleep Research Centre, Department of Neurology IC Oasi Research Institute \u2013 IRCCS  Troina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"Frauscher","sequence":"additional","affiliation":[{"name":"Duke University  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evi","family":"Holzknecht","sequence":"additional","affiliation":[{"name":"Medical University Innsbruck  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9063-2658","authenticated-orcid":false,"given":"Federica","family":"Provini","sequence":"additional","affiliation":[{"name":"Department of Biomedical and NeuroMotor Sciences University of Bologna  Bologna Italy"},{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Schormair","sequence":"additional","affiliation":[{"name":"Institute of Neurogenomics Computational Health Department  Helmholtz Munich, Munich Germany"},{"name":"Institute of Human Genetics, TUM School of Medicine and Health Technical University Munich  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Winkelman","sequence":"additional","affiliation":[{"name":"Departments of Psychiatry and Neurology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"H\u00f6gl","sequence":"additional","affiliation":[{"name":"Medical University Innsbruck  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ANA.27040"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsmc.2015.05.022"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMOA1303646"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/SLEEP\/19.3.205"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2017.11.1126"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2014.03.025"},{"key":"e_1_2_10_8_1","unstructured":"American Academy of Sleep Medicine.2023.\u201cThe AASM International Classification of Sleep Disorders \u2013 Third Edition. Text Revision (ICSD\u20103\u2010TR)\u201d."},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2014.10.007"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JSMC.2021.02.008"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/JSR.13921"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/JSR.14074"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2024.05.044"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2023.04.003"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/SLEEP\/ZSAD190"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/JSR.13783"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013\u20104694(84)90152\u20104"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.brain.a101857"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2014.01.024"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/FGENE.2020.00424\/PDF"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/MDS.30274"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/BRAIN\/AWP125"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000123251.60485.AC"},{"key":"e_1_2_10_24_1","article-title":"Su di un fenomeno motorio costante del sonno normale: le mioclonie ipniche fisiologiche","volume":"481","author":"De Lisi L.","year":"1932","journal-title":"Rivista di Patologia Nervosa e Mentale"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.5664\/JCSM.8718"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/JSR.12870"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2020.08.011"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2020.07.033"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/S42003\u2010020\u201001430\u20101"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.SLEEP.2014.05.009"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2005.09.006"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/MDS.25627"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858418791763"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/SLEEP\/ZSAB092"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1126\/SCITRANSLMED.AAG1166"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/SLEEP\/33.8.1091"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.5665\/SLEEP.3586"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2010.08.016"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2017.03.012"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/MDS.28668"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2018.02.002"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2016.01.017"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2007.03.022"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/ENE.15221"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/PNAS.0708930105"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00415\u2010009\u20105299\u20108"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.2147\/NSS.S331893"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/SLEEP\/ZSAD129"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/MDC3.14306"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002504"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/SLEEP\/ZSAA165"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/SLEEP\/19.3.224"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41586\u2010024\u201007316\u20100"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/SLEEP\/ZSAE113"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/JSR.14447"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/SLEEP\/ZSAE310"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00415\u2010004\u20100478\u20100"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/MDS.870120112"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.5664\/JCSM.9600"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/NG.3314"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.0954\u20106820.1953.TB07042.X"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/D41573\u2010022\u201000120\u20103"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.SLEEP.2017.06.030"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2016.09.002"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2016.04.018"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41576\u2010021\u201000387\u2010Z"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.3390\/MOLECULES27051489"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41588\u2010024\u201001763\u20101"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2020.12.026"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2010.11.002"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1186\/S42466\u2010024\u201000353\u20100"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/24.7.835"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.4.644"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/MDS.1214"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/S41105\u2010024\u201000524\u20101"},{"key":"e_1_2_10_76_1","unstructured":"Willis T.1685.\u201cThe London Practice of Physick or the Whole Practical Part of Physick Contained in the Works of Dr. Willis Faithfully Made English and Printed Together for the Publick Good.\u201dAccessed 26 August 2025.https:\/\/name.umdl.umich.edu\/A66498.0001.001."},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.5664\/JCSM.11392"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.5664\/JCSM.11390"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000206855"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/JSR.12831"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2024.08.024"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/ANA.25104"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2020.08.018"}],"container-title":["Journal of Sleep Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsr.70210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T07:04:49Z","timestamp":1762499089000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jsr.70210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,3]]},"references-count":82,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/jsr.70210"],"URL":"https:\/\/doi.org\/10.1111\/jsr.70210","archive":["Portico"],"relation":{},"ISSN":["0962-1105","1365-2869"],"issn-type":[{"value":"0962-1105","type":"print"},{"value":"1365-2869","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,3]]},"assertion":[{"value":"2025-08-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70210"}}