{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T05:34:42Z","timestamp":1784871282946,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["COST Action B26"],"award-info":[{"award-number":["COST Action B26"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008593","name":"European Respiratory Society","doi-asserted-by":"publisher","award":["CRC"],"award-info":[{"award-number":["CRC"]}],"id":[{"id":"10.13039\/100008593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003305","name":"ResMed Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003305","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004326","name":"Bayer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Excessive daytime sleepiness (EDS) as well as insomnia have been associated with a higher risk for cardiovascular disease in patients with obstructive sleep apnoea (OSA). The link is not fully understood but may involve dyslipidaemia. The aim of the study was to analyse if the EDS and insomnia phenotypes were associated with deranged serum lipid values in patients with OSA recruited from a European real\u2010world cohort. Patients with OSA and a full lipid profile participating in the ESADA database were analysed (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200912,153). Based on their symptoms, they were categorised into EDS (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20093123), EDS\u2009+\u2009insomnia (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20092091), insomnia (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20092862) and non\u2010EDS non\u2010insomnia (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20094077) subgroups. Nonparametric ANCOVA adjusted for age, body mass index, smoking, alcohol, study site, apnoea\u2010hypopnoea index and time spent with saturation below 90%, followed by Dunn's test and Bonferroni correction, was used to compare lipid values between the groups. The analyses were also performed in predefined subgroups. There were significant differences in total cholesterol (TC), LDL\u2010cholesterol (LDL\u2010C), HDL\u2010cholesterol (HDL\u2010C) and triglyceride (TG) values between the four groups (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). Patients with EDS had the highest TC (5.11\u2009\u00b1\u20091.08 vs. 5.00\u2009\u00b1\u20091.10, 5.03\u2009\u00b1\u20091.12, 5.04\u2009\u00b1\u20091.10\u2009mmol\/L, EDS vs. EDS\u2009+\u2009insomnia, insomnia, non\u2010EDS non\u2010insomnia, respectively), LDL\u2010C (3.12\u2009\u00b1\u20090.97 vs. 3.01\u2009\u00b1\u20090.98, 3.02\u2009\u00b1\u20091.00, 3.09\u2009\u00b1\u20090.98\u2009mmol\/L) and TG (1.86\u2009\u00b1\u20091.04 vs. 1.76\u2009\u00b1\u20090.97, 1.69\u2009\u00b1\u20090.90, 1.75\u2009\u00b1\u20090.93\u2009mmol\/L) values and the lowest HDL\u2010C results (1.18\u2009\u00b1\u20090.33 vs. 1.21\u2009\u00b1\u20090.34, 1.26\u2009\u00b1\u20090.38, 1.20\u2009\u00b1\u20090.34). Interestingly, patients with insomnia had the highest HDL\u2010C values. EDS is significantly associated with dyslipidaemia in patients with OSA. Further studies are warranted to understand the link in detail and to translate it into clinical practice.\n                  <\/jats:p>","DOI":"10.1111\/jsr.70240","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T11:58:22Z","timestamp":1762862302000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Excessive Daytime Sleepiness, but Not Insomnia Is Associated With Dyslipidaemia in Patients With Obstructive Sleep Apnoea Participating in\n                    <scp>ESADA<\/scp>"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8983-740X","authenticated-orcid":false,"given":"Andras","family":"Bikov","sequence":"first","affiliation":[{"name":"Wythenshawe Hospital Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre  Manchester UK"},{"name":"Division of Infection, Immunity &amp; Respiratory Medicine, Faculty of Biology, Medicine and Health The University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastien","family":"Bailly","sequence":"additional","affiliation":[{"name":"Grenoble Alpes University Inserm, CHU Grenoble Alpes  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulla","family":"Anttalainen","sequence":"additional","affiliation":[{"name":"Division of Medicine, Department of Pulmonary Diseases Turku University Hospital and Sleep Research Centre  Turku Finland"},{"name":"Department of Pulmonary Diseases and Clinical Allergology University of Turku  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarja","family":"Saaresranta","sequence":"additional","affiliation":[{"name":"Division of Medicine, Department of Pulmonary Diseases Turku University Hospital and Sleep Research Centre  Turku Finland"},{"name":"Department of Pulmonary Diseases and Clinical Allergology University of Turku  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8168-6611","authenticated-orcid":false,"given":"Ozen K.","family":"Basoglu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Faculty of Medicine Ege University  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Schiza","sequence":"additional","affiliation":[{"name":"Sleep Disorders Center, Department of Respiratory Medicine, School of Medicine University of Crete  Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izolde","family":"Bouloukaki","sequence":"additional","affiliation":[{"name":"Sleep Disorders Center, Department of Respiratory Medicine, School of Medicine University of Crete  Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawel","family":"Sliwinski","sequence":"additional","affiliation":[{"name":"Second Department of Respiratory Medicine Institute of Tuberculosis and Lung Diseases  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasia","family":"Pataka","sequence":"additional","affiliation":[{"name":"Respiratory Failure Unit, G Papanikolaou Hospital, School of Medicine Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dries","family":"Testelmans","sequence":"additional","affiliation":[{"name":"Department of Pneumology University Hospitals Leuven  Leuven Belgium"},{"name":"Department of Chronic Diseases and Metabolism Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE)  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Fanfulla","sequence":"additional","affiliation":[{"name":"Sleep Medicine Unit\u2014Istituti Clinici Scientifici Maugeri\u2014Istituto Scientifico di Pavia e Montescano IRCCS  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haralampos","family":"Gouveris","sequence":"additional","affiliation":[{"name":"ENT Department at Mainz University Hospital  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7405-1682","authenticated-orcid":false,"given":"Ludger","family":"Grote","sequence":"additional","affiliation":[{"name":"Center for Sleep and Wake Disorders, Institute of Medicine, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Pulmonary Medicine, Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Mihaicuta","sequence":"additional","affiliation":[{"name":"Center for Research and Innovation in Precision Medicine of Respiratory Diseases, Department of Pulmonology \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara  Timisoara Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the ESADA collaborators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325\u2010018\u20101757\u20109"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.14012"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10122457"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9113583"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.3226"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00151110"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.690008"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11030596"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsae240"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241814145"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsx130"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.117.005479"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.119.013043"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2025.02.035"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12952"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2020.02.023"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.13372"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00046710"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/07448481.2020.1799805"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/crj.12276"},{"key":"e_1_2_10_22_1","volume-title":"The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications","author":"Iber C.","year":"2007"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.13563"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01958\u20102021"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.4178\/epih.e2024031"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931\u2010019\u20101248\u2010y"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.120.020187"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201808\u20101509OC"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10112754"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12979"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3182160726"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325\u2010010\u20100472\u2010y"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325\u2010012\u20100655\u20109"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2018.07.014"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569\u2010023\u201000846\u20106"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163439"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2011.08.014"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13690\u2010020\u201000429\u20108"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2025.106526"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11081848"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2012.09.005"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/32.4.491"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.5524"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad089"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12902\u2010025\u201001850\u20102"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.97.18.1837"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888\u2010018\u20101734\u20107"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc21\u20101107"}],"container-title":["Journal of Sleep Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsr.70240","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jsr.70240","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsr.70240","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T06:05:13Z","timestamp":1779257113000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jsr.70240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,11]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/jsr.70240"],"URL":"https:\/\/doi.org\/10.1111\/jsr.70240","archive":["Portico"],"relation":{},"ISSN":["0962-1105","1365-2869"],"issn-type":[{"value":"0962-1105","type":"print"},{"value":"1365-2869","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,11]]},"assertion":[{"value":"2025-06-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70240"}}