{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T06:16:12Z","timestamp":1779257772121,"version":"3.51.4"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100014180","name":"Junta de Castilla y Le\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014180","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007515","name":"Universidad de Valladolid","doi-asserted-by":"publisher","award":["UVa PROYEMER\u20102021\u201057"],"award-info":[{"award-number":["UVa PROYEMER\u20102021\u201057"]}],"id":[{"id":"10.13039\/501100007515","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Obstructive sleep apnea (OSA), marked by intermittent hypoxia, is associated with obesity, type 2 diabetes and metabolic associated fatty liver disease. In pregnancy, it remains underdiagnosed despite links to gestational diabetes, hypertension, and foetal growth restriction. Intermittent hypoxia may alter foetal programming and increase the risk of long\u2010term metabolic issues in offspring. This study evaluates the effects of gestational OSA on offspring metabolic function, focusing on weight gain, glucose homeostasis, insulin sensitivity, hepatic glucose metabolism, inflammation and oxidative stress. Experiments were performed on pregnant female Wistar rats submitted to a chronic intermittent hypoxia (CIH) protocol during the last 2\u2009weeks of pregnancy. Offspring were evaluated for body weight, glucose tolerance and insulin sensitivity at 1, 3, and 12\u2009months of age. Liver western blot analysis was performed to assess markers of glucose metabolism (glucokinase, pyruvate kinase and glucose\u20106\u2010phosphatase), inflammation (NF\u2010kB, IL\u20101R, IL\u20106R, TNF\u2010\u0251R and NRLP3) and antioxidant enzymes (catalase, SOD\u20101 and iNOS). CIH did not modify body weight, glucose tolerance and insulin sensitivity at 1, 3 and 12\u2009months of age, except for a transient increase in glucose intolerance observed in 3\u2010month\u2010old females, which was attenuated by 12\u2009months. Moreover, no evidence was found of modifications caused by gestational CIH on markers of hepatic glucose metabolism, inflammation or antioxidant defence. However, there was a gradual increase in inflammation with age. No sexual dimorphism was observed. Overall, these findings suggest that gestational CIH does not predispose offspring to long\u2010term metabolic dysfunction later in life and does not affect biological ageing, regardless of sex.<\/jats:p>","DOI":"10.1111\/jsr.70245","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T14:03:58Z","timestamp":1763129038000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exposure to Gestational Intermittent Hypoxia Does Not Impair the Metabolic Function or Accelerate the Biological Ageing Process of Offspring of Either Sex"],"prefix":"10.1111","volume":"35","author":[{"given":"Esther","family":"Valverde\u2010Perez","sequence":"first","affiliation":[{"name":"Instituto de Biomedicina y Gen\u00e9tica Molecular (IBGM) Consejo Superior de Investigaciones Cient\u00edficas \u2013 Universidad de Valladolid  Valladolid Spain"},{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular y Fisiolog\u00eda, Facultad de Medicina Universidad de Valladolid  Valladolid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarida B.","family":"Almeida","sequence":"additional","affiliation":[{"name":"INOVA4Health, NOVA Medical School, Faculdade de Ci\u00eancias M\u00e9dicas Universidade NOVA de Lisboa  Lisboa Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joana F.","family":"Sacramento","sequence":"additional","affiliation":[{"name":"INOVA4Health, NOVA Medical School, Faculdade de Ci\u00eancias M\u00e9dicas Universidade NOVA de Lisboa  Lisboa Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Olea","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina y Gen\u00e9tica Molecular (IBGM) Consejo Superior de Investigaciones Cient\u00edficas \u2013 Universidad de Valladolid  Valladolid Spain"},{"name":"Departamento de Enfermer\u00eda, Facultad de Enfermeria Universidad de Valladolid  Valladolid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesus","family":"Prieto\u2010Lloret","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina y Gen\u00e9tica Molecular (IBGM) Consejo Superior de Investigaciones Cient\u00edficas \u2013 Universidad de Valladolid  Valladolid Spain"},{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular y Fisiolog\u00eda, Facultad de Medicina Universidad de Valladolid  Valladolid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9043-0474","authenticated-orcid":false,"given":"Asuncion","family":"Rocher","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina y Gen\u00e9tica Molecular (IBGM) Consejo Superior de Investigaciones Cient\u00edficas \u2013 Universidad de Valladolid  Valladolid Spain"},{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular y Fisiolog\u00eda, Facultad de Medicina Universidad de Valladolid  Valladolid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia V.","family":"Conde","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina y Gen\u00e9tica Molecular (IBGM) Consejo Superior de Investigaciones Cient\u00edficas \u2013 Universidad de Valladolid  Valladolid Spain"},{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular y Fisiolog\u00eda, Facultad de Medicina Universidad de Valladolid  Valladolid Spain"},{"name":"INOVA4Health, NOVA Medical School, Faculdade de Ci\u00eancias M\u00e9dicas Universidade NOVA de Lisboa  Lisboa Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph22020214"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.13418"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00303.2019"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.674997"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000065506"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.04.022"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169850"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP277775"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP277936"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00003413"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010020\u201003566\u2010z"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S2040174420000355"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12111910"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0047\u20106374(97)00102\u20104"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357\u2010012\u20109475\u2010x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2015.122"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metop.2022.100177"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0736\u20105748(95)00071\u20102"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.08.027"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.578001"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bj.2022.10.003"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00345.2018"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(13)60734\u20105"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05482"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP273570"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1261298"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.07.009"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.15"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2018\u201000248"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2007.11.003"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/neurolint16030039"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1239145"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12030403"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11010054"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.2350\/15\u201006\u20101647\u2010OA.1"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00586"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2017.05.009"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1159\/000213320"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2023.101868"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14\u20100970"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21593"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP090442"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25031852"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032\u2010021\u201000739\u20104"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.30387"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201029052\u2010y"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.14435"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010031\u201032371\u20103_8"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3001502"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.907228"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1067683"}],"container-title":["Journal of Sleep Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsr.70245","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jsr.70245","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsr.70245","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T06:04:52Z","timestamp":1779257092000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jsr.70245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,14]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/jsr.70245"],"URL":"https:\/\/doi.org\/10.1111\/jsr.70245","archive":["Portico"],"relation":{},"ISSN":["0962-1105","1365-2869"],"issn-type":[{"value":"0962-1105","type":"print"},{"value":"1365-2869","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,14]]},"assertion":[{"value":"2025-07-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70245"}}