{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:31:53Z","timestamp":1792146713412,"version":"4.4.0"},"reference-count":83,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1197439"],"award-info":[{"award-number":["1197439"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Insomnia disorder is harmful and requires novel treatments. Cannabinol, an oxidative by\u2010product of \u03949\u2010tetrahydrocannabinol, is claimed to be a hypnotic, but its effects on objective sleep and insomnia remain unknown. This randomized, double\u2010blind, placebo\u2010controlled, three\u2010arm, single\u2010night crossover trial evaluated the acute efficacy and safety of cannabinol for insomnia disorder. Twenty adults (aged 25\u201365) with physician\u2010diagnosed insomnia disorder (meeting DSM\u20105 and ICSD\u20103 criteria; Insomnia Severity Index \u2265\u200915) were enrolled at the Woolcock Institute of Medical Research (Sydney, Australia) between August 2022 and September 2023. Participants received a single 2\u2009mL oral dose of 30\u2009mg (1.5%) or 300\u2009mg (15%) cannabinol, or matched placebo (2\u2010week washout). All participants (17 female and 3 males; mean\u2009\u00b1\u2009SD age 42\u2009\u00b1\u200913\u2009years) completed the protocol and were statistically analysed. The primary outcome was wake after sleep onset (WASO) minutes, measured by overnight polysomnography. Cannabinol did not significantly change WASO (300\u2009mg: \u22126.3 min [95% CI: \u221218.2, +5.5],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.29,\n                    <jats:italic>dz<\/jats:italic>\n                    \u2009=\u2009\u22120.22; 30\u2009mg: \u22124.0 min [\u221215.9, +7.9],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.50,\n                    <jats:italic>dz<\/jats:italic>\n                    \u2009=\u20090.11). However, 300\u2009mg cannabinol increased non\u2010rapid eye movement\u20102 sleep (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03,\n                    <jats:italic>dz<\/jats:italic>\n                    \u2009=\u20090.54), subjective sleep quality (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.005,\n                    <jats:italic>dz<\/jats:italic>\n                    \u2009=\u20090.56); and reduced sleep onset latency (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.004,\n                    <jats:italic>dz<\/jats:italic>\n                    \u2009=\u2009\u22120.74) and electroencephalographic arousal indices (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02,\n                    <jats:italic>dz<\/jats:italic>\n                    \u2009=\u2009\u22120.65). There were 247 mild\u2010to\u2010moderate adverse events across arms. Larger, longer trials are warranted.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                    Identifier: NCT05344170.\n                  <\/jats:p>","DOI":"10.1111\/jsr.70284","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T02:15:27Z","timestamp":1771294527000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cannabinol for Acute Treatment of Insomnia Disorder in a Randomized Placebo\u2010Controlled Crossover Trial"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8927-7924","authenticated-orcid":false,"given":"Isobel G.","family":"Lavender","sequence":"first","affiliation":[{"name":"Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research 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