{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:53:31Z","timestamp":1790200411450,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF17OC0024718"],"award-info":[{"award-number":["NNF17OC0024718"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF20SA0067242"],"award-info":[{"award-number":["NNF20SA0067242"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R211\u20102015\u20102937"],"award-info":[{"award-number":["R211\u20102015\u20102937"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This pilot observational study evaluated whether frequent overnight sampling of ventricular cerebrospinal fluid could clarify how sleep, hypocretin and lactate relate to amyloid\u2010\u03b242 dynamics in adults with hydrocephalus. Seven participants underwent hourly ventricular cerebrospinal fluid sampling from early evening to late morning during inpatient monitoring, combined with full polysomnography. Concentrations of amyloid\u2010\u03b242, hypocretin, lactate, melatonin and electrolytes were measured and normalised to each individual's mean. Relationships with sleep stage and circadian patterns were examined using correlation analysis and cosinor modelling. Sleep was markedly disrupted, with obstructive sleep apnea common and analysable sleep data available for six participants. Non\u2010rapid eye movement sleep peaked at approximately 4\u2009AM Amyloid\u2010\u03b242 rose in the evening, plateaued during peak non\u2010rapid eye movement sleep and increased sharply after 8\u2009AM Hypocretin and lactate were positively correlated and each preceded and correlated with amyloid\u2010\u03b242 surges. Melatonin peaked near 6\u2009AM and was associated with non\u2010rapid eye movement sleep. Intracranial pressure displayed a strong circadian rhythm, peaking during non\u2010rapid eye movement sleep, whereas hypocretin and amyloid\u2010\u03b242 exhibited only modest rhythmicity. These findings demonstrate that overnight ventricular cerebrospinal fluid sampling is feasible in adults with hydrocephalus. Preliminary evidence suggests that processes linked to wakefulness, rather than sleep or intrinsic circadian timing, may be the primary drivers of overnight amyloid\u2010\u03b242 variation. Hypocretin pathways may represent potential therapeutic targets in Alzheimer's disease, but conclusions are limited by abnormal sleep architecture and underlying neurological disease. Validation in larger and more representative populations is warranted.<\/jats:p>","DOI":"10.1111\/jsr.70292","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T09:30:54Z","timestamp":1769679054000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Overnight Dynamics of Ventricular Cerebrospinal Fluid Amyloid\u2010Beta, Lactate and Hypocretin in Patients With Hydrocephalus: A Pilot Study"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9393-0092","authenticated-orcid":false,"given":"Casper Schwartz","family":"Riedel","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Centre of Neuroscience Copenhagen University Hospital\u2014Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Neurophysiology, Danish Center for Sleep Medicine Copenhagen University Hospital\u2014Rigshospitalet  Glostrup Denmark"},{"name":"Centre 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Hospital\u2014Rigshospitalet  Glostrup Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2652-7495","authenticated-orcid":false,"given":"Marianne","family":"Juhler","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Centre of Neuroscience Copenhagen University Hospital\u2014Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen 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