{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:00:20Z","timestamp":1790622020188,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100013373","name":"NIHR Oxford Biomedical Research Centre","doi-asserted-by":"publisher","award":["BRC\u20101215\u201020008"],"award-info":[{"award-number":["BRC\u20101215\u201020008"]}],"id":[{"id":"10.13039\/501100013373","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Insomnia may play a causal role in type 2 diabetes (T2D). Addressing insomnia through cognitive behavioural therapy (CBTi) in people with non\u2010diabetic hyperglycaemia could potentially reduce the risk of progression to T2D. To inform a future randomised trial, we performed a feasibility study of digital CBT (dCBTi) in individuals at increased risk of T2D. Participants were identified from 10 primary care practices in the UK and given access to dCBTi. Outcomes were evaluated at baseline (Week\u20100) and post\u2010treatment (Week\u201011). Primary feasibility outcomes were ability to recruit and treatment engagement. We also quantified within\u2010group mean change (95% CI) in insomnia severity (Insomnia Severity Index), health\u2010related quality of life (EQ\u20105D\u20103L), depression (Center for Epidemiologic Studies Depression Scale), chronotype (reduced Morningness\u2010Eveningness Questionnaire), sleep (7\u2010day actigraphy and diary), continuous glucose monitoring (7\u2010days) and fasting blood metabolites (insulin, lipids, glucose and C\u2010reactive protein). The recruitment target was 20. Of 242 people completing screening, 36 were eligible and 24 were enrolled (age 65.5\u2009\u00b1\u200912.4\u2009years, 70.8% female). Twenty\u2010three (96%) completed post\u2010intervention assessments. Treatment engagement was excellent (83.3% completed \u2265\u20094 sessions). The intervention was associated with a large reduction in insomnia severity [\u22124.7 (95% CI: \u22126.2 to \u22123.2),\n                    <jats:italic>d<\/jats:italic>\n                    \u2009=\u2009\u22121.4] and medium reduction in depressive symptoms [\u22122.7 (95% CI: \u22125.1 to \u22120.2),\n                    <jats:italic>d<\/jats:italic>\n                    \u2009=\u2009\u22120.5]. Sleep diary parameters tended to show greater improvement following intervention relative to actigraphy. There was evidence of a reduction in serum lactate, glycerol and triglycerides but no clear change in glucose or insulin. Results suggest a full trial is likely feasible and that people with NDH find the intervention acceptable and beneficial.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    This trial was prospectively registered on the UKs clinical study registry, the ISRCTN (ISRCTN19682964,\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/doi.org\/10.1186\/ISRCTN19682964\">https:\/\/doi.org\/10.1186\/ISRCTN19682964<\/jats:ext-link>\n                    )\n                  <\/jats:p>","DOI":"10.1111\/jsr.70306","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T02:59:42Z","timestamp":1771210782000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sleep Improvement for Metabolic Health: A Feasibility Trial of a Digital Sleep Treatment in People With Insomnia and Non\u2010Diabetic Hyperglycaemia"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1683-0477","authenticated-orcid":false,"given":"Rachel","family":"Sharman","sequence":"first","affiliation":[{"name":"Sir Jules Thorn Sleep and Circadian Neuroscience Institute Nuffield Department of Clinical Neurosciences, University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ray","sequence":"additional","affiliation":[{"name":"Sir Jules Thorn Sleep and Circadian Neuroscience Institute Nuffield Department of Clinical Neurosciences, University of Oxford  Oxford UK"},{"name":"Oxford Centre for Diabetes, Endocrinology and Metabolism University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Farmer","sequence":"additional","affiliation":[{"name":"Nuffield Department of Primary Care Health Sciences University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poppy C. E.","family":"Green","sequence":"additional","affiliation":[{"name":"Sir Jules Thorn Sleep and Circadian Neuroscience Institute Nuffield Department of Clinical Neurosciences, University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Harris","sequence":"additional","affiliation":[{"name":"Nuffield Department of Primary Care Health Sciences University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"Karpe","sequence":"additional","affiliation":[{"name":"Oxford Centre for Diabetes, Endocrinology and Metabolism University of Oxford  Oxford UK"},{"name":"NIHR Oxford Biomedical Research Centre, OUH Trust  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1294-8734","authenticated-orcid":false,"given":"Colin A.","family":"Espie","sequence":"additional","affiliation":[{"name":"Sir Jules Thorn Sleep and Circadian Neuroscience Institute Nuffield Department of Clinical Neurosciences, University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Mantripp","sequence":"additional","affiliation":[{"name":"Oxford Centre for Diabetes, Endocrinology and Metabolism University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Marjot","sequence":"additional","affiliation":[{"name":"Oxford Centre for Diabetes, Endocrinology and Metabolism University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niall M.","family":"McGowan","sequence":"additional","affiliation":[{"name":"Sir Jules Thorn Sleep and Circadian Neuroscience Institute Nuffield Department of Clinical Neurosciences, University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy W.","family":"Tomlinson","sequence":"additional","affiliation":[{"name":"Oxford Centre for Diabetes, Endocrinology and Metabolism University of Oxford  Oxford UK"},{"name":"NIHR Oxford Biomedical Research Centre, OUH Trust  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon D.","family":"Kyle","sequence":"additional","affiliation":[{"name":"Sir Jules Thorn Sleep and Circadian Neuroscience Institute Nuffield Department of Clinical Neurosciences, University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0191-8869(91)90110-W"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(22)01655\u20105"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(22)00319\u20109"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0248560"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/33.5.585"},{"key":"e_1_2_11_7_1","doi-asserted-by":"crossref","unstructured":"Carney C. 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S.Toniolo Q.\u2010Y.Tang et\u00a0al.2025.\u201cOCTAL (Oxford Cognitive Testing Portal): A Remote Cross\u2010Cultural Cognitive Assessment Detects Domain\u2010Specific Aging and Dementia.\u201dhttps:\/\/doi.org\/10.1101\/2025.06.23.25330153.","DOI":"10.1101\/2025.06.23.25330153"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(24)02317\u20101"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2019.02.002"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc23\u20101156"}],"container-title":["Journal of Sleep Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsr.70306","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jsr.70306","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsr.70306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:11:00Z","timestamp":1790619060000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jsr.70306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,15]]},"references-count":56,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/jsr.70306"],"URL":"https:\/\/doi.org\/10.1111\/jsr.70306","archive":["Portico"],"relation":{},"ISSN":["0962-1105","1365-2869"],"issn-type":[{"value":"0962-1105","type":"print"},{"value":"1365-2869","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,15]]},"assertion":[{"value":"2025-08-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70306"}}