{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:14:36Z","timestamp":1787015676330,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100023510","name":"UZH Foundation","doi-asserted-by":"publisher","award":["STWF\u201023\u2010010"],"award-info":[{"award-number":["STWF\u201023\u2010010"]}],"id":[{"id":"10.13039\/501100023510","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Data on sleep and respiratory patterns among adolescents residing at very high altitude (&gt;\u20093500\u2009m) remain scarce, and altitude\u2010related physiological differences may influence these parameters. Studying adolescents at different very high altitudes is crucial, as subtle environmental variations could affect sleep\u2010related oxygenation and respiratory function. This study aimed to characterise sleep\u2010related oxygenation and respiratory parameters in healthy adolescents native to two distinct very high\u2010altitude environments. Overnight sleep polygraphy was performed in 163 healthy adolescents aged 13.5 to &lt; 18\u2009years living in La Paz (3620\u2009m) and El Alto (4060\u2009m), Bolivia. Mean nocturnal oxygen saturation, oxygen desaturation index, and apnea\u2013hypopnea index were assessed alongside subjective sleep quality, morning blood pressure, heart rate, haemoglobin concentration, and Epworth Sleepiness Scale scores. Adolescents at 4060\u2009m had significantly lower mean nocturnal oxygen saturation (84.8%\u2009\u00b1\u20092.2%) compared with those at 3620\u2009m (87.8%\u2009\u00b1\u20091.8%), and a higher oxygen desaturation index (21.2\u2009\u00b1\u20098.5\/h vs. 17.1\u2009\u00b1\u20099.0\/h). The apnea\u2010hypopnea index did not differ significantly between altitudes (6.2\u2009\u00b1\u20094.8\/h vs. 5.6\u2009\u00b1\u20094.6\/h). At 3620\u2009m, females showed lower oxygen desaturation and apnea\u2010hypopnea indices compared with males. Despite the more pronounced nocturnal hypoxemia at 4060\u2009m, haemoglobin concentration did not increase, suggesting limited haematological compensation. Subjective sleep quality, blood pressure, and heart rate were similar between both altitude groups. Healthy adolescents living chronically at very high altitude exhibit altitude\u2010dependent reductions in nocturnal oxygenation and increased desaturation frequency, without evidence of sleep\u2010disordered breathing. These findings underscore the need for altitude\u2010specific normative values to support accurate interpretation of sleep studies in high\u2010altitude populations.<\/jats:p>","DOI":"10.1111\/jsr.70326","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T07:27:16Z","timestamp":1773646036000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nocturnal Sleep Breathing Patterns in Healthy Adolescents Residing at Very High Altitudes in Bolivia"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6848-5278","authenticated-orcid":false,"given":"Keaton","family":"Patterson","sequence":"first","affiliation":[{"name":"Institute of Veterinary Physiology, Vetsuisse Faculty University of Z\u00fcrich  Z\u00fcrich Switzerland"},{"name":"Department of Pulmonology University Hospital Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5868-1265","authenticated-orcid":false,"given":"Santiago Ucr\u00f3s","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Universidad de Los Andes  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Nicol\u00e1s","family":"Arancibia\u2010Levit","sequence":"additional","affiliation":[{"name":"Universidad Privada de Santa Cruz de la Sierra (UPSA)  Santa Cruz Bolivia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Aliaga","family":"Raduan","sequence":"additional","affiliation":[{"name":"Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec (IUCPQ) Laval University  Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0579-5186","authenticated-orcid":false,"given":"Jos\u00e9 Antonio Viruez","family":"Soto","sequence":"additional","affiliation":[{"name":"Hospital del Norte  El Alto Bolivia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Gassmann","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Physiology, Vetsuisse Faculty University of Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Ulrich","sequence":"additional","affiliation":[{"name":"Department of Pulmonology University Hospital Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Furian","sequence":"additional","affiliation":[{"name":"Department of Pulmonology University Hospital Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7371-1477","authenticated-orcid":false,"given":"Edith M.","family":"Schneider Gasser","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Physiology, Vetsuisse Faculty University of Z\u00fcrich  Z\u00fcrich Switzerland"},{"name":"Department of Pulmonology University Hospital Z\u00fcrich  Z\u00fcrich Switzerland"},{"name":"Universidad Privada de Santa Cruz de la Sierra (UPSA)  Santa Cruz Bolivia"},{"name":"Zurich Neuroscience Center (ZNZ) University of Z\u00fcrich and ETH Z\u00fcrich  Z\u00fcrich 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