{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:00:17Z","timestamp":1790622017773,"version":"4.1.0"},"reference-count":9,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T00:00:00Z","timestamp":1777161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T00:00:00Z","timestamp":1777161600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100016372","name":"Desitin Arzneimittel","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016372","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","award":["20180585"],"award-info":[{"award-number":["20180585"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","award":["20210529"],"award-info":[{"award-number":["20210529"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","award":["20210500"],"award-info":[{"award-number":["20210500"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cortical arousals significantly impact obstructive sleep apnoea (OSA) pathophysiology and cardiovascular consequences, often mediated by sympathetic activation. While pulse oximetry (PPG) provides an accessible reflection of autonomic responses such as changes in pulse rate (PR) and pulse wave amplitude (PWA), the dynamic influence on other vascular indices remains less explored. We investigated dynamic changes in PPG\u2010derived pulse propagation time (PPT), a metric reflecting modulation in vascular stiffness. It is hypothesised that PPT beat\u2010to\u2010beat responses to arousals are specific and independent from other pulse wave parameters. Polysomnography data from 87 patients were analysed (mean age 54\u2009\u00b1\u200912\u2009years, 26% female, mean BMI 27.7\u2009\u00b1\u20093.6\u2009kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    , mean Apnea\u2010Hypopnea Index 33\u2009\u00b1\u200923 events\/h; total 18,275 respiratory events). The mean percentage change (shortening, vascular stiffening) of the PPT following respiratory events was significantly greater when accompanied by an EEG arousal in both apnoeas (\u221221.1% vs. \u221217.9%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and hypopneas (\u221219.4% vs. \u221217.0%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). In a multivariate logistic mixed\u2010effect model, \u2206PPT emerged as an independent predictor of EEG arousal presence (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001, scaled odds ratio: 1.14; 95% CI: 1.09\u20131.20), accounting for event type, anthropometrics and changes in PWA, PR, SpO\n                    <jats:sub>2<\/jats:sub>\n                    . Dynamic, short\u2010term changes in PPG\u2010derived PPT are significantly associated with cortical arousals following respiratory events in OSA patients. This parameter provides independent predictive information beyond established PPG metrics, likely reflecting rapid, arousal\u2010induced alterations in vascular tone. These findings highlight a novel PPG\u2010based marker that could quantify the vascular stress in OSA.\n                  <\/jats:p>","DOI":"10.1111\/jsr.70343","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T02:55:43Z","timestamp":1777258543000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Vascular Dynamics During Respiratory Arousal From Sleep Assessed by Oximeter\u2010Based Vascular Stiffness Measures"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4629-3155","authenticated-orcid":false,"given":"Christian","family":"Strassberger","sequence":"first","affiliation":[{"name":"Center for Sleep and Vigilance Disorders, Institute of Medicine, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding","family":"Zou","sequence":"additional","affiliation":[{"name":"Center for Sleep and Vigilance Disorders, Institute of Medicine, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Hedner","sequence":"additional","affiliation":[{"name":"Center for Sleep and Vigilance Disorders, Institute of Medicine, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Center for Sleep Medicine, Department of Respiratory Medicine Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7405-1682","authenticated-orcid":false,"given":"Ludger","family":"Grote","sequence":"additional","affiliation":[{"name":"Center for Sleep and Vigilance Disorders, Institute of Medicine, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Center for Sleep Medicine, Department of Respiratory Medicine Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202010-3900OC"},{"key":"e_1_2_6_3_1","volume-title":"The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications. Version 2.4","author":"Berry R. B.","year":"2017"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/25.7.797"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1569-9048(03)00090-9"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2024.02.059"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/app12041798"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.1983.tb00895.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11517-015-1410-8"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001111"}],"container-title":["Journal of Sleep Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsr.70343","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jsr.70343","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsr.70343","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:10:35Z","timestamp":1790619035000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jsr.70343"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,26]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/jsr.70343"],"URL":"https:\/\/doi.org\/10.1111\/jsr.70343","archive":["Portico"],"relation":{},"ISSN":["0962-1105","1365-2869"],"issn-type":[{"value":"0962-1105","type":"print"},{"value":"1365-2869","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,26]]},"assertion":[{"value":"2025-07-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70343"}}