{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:59:19Z","timestamp":1790621959334,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The onset of altitude\u2010induced central sleep apnea (CSA) varies among individuals and may be influenced by genetic factors affecting respiratory control. Tibetans, who have undergone high\u2010altitude adaptation over generations, may exhibit physiologic traits that protect against CSA. This study investigated the impact of Tibetan ancestry on respiratory control and hypoxia\u2010induced CSA. Nine healthy unacclimatized Tibetans living in Switzerland for at least 5\u2009years and 20 Caucasians (all males; median[IQR] age: 28 [27\u201332] vs. 24 [23.5\u201326] years; median[IQR] BMI: 23.8 [23.1\u201328] vs. 22.1[21.2\u201323.1]kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ) underwent two full polysomnographies, one at low altitude and one in a hypoxic chamber simulating 3500\u2009m. The apnea\u2010hypopnea index (AHI) and the percentage of sleep spent in periodic breathing (PB) were calculated. A hyperoxic hypercapnic ventilatory response (HCVR) test and hypoxic ventilatory response tests at rest (HVRr) and during exercise (HVRe) were performed. Parameters were compared between groups using non\u2010parametric tests. At simulated altitude, Tibetans exhibited a significantly lower AHI (51.2 [12.7\u201372.1]\/h vs. 107.0 [36.7\u2013140.3]\/h;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0231) and spent less sleep time in PB (27.6 [2.6\u201344.5]% vs. 58.8 [14.0\u201389.0]%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0334) compared to Caucasians. HCVR did not differ significantly between groups (Tibetans: 1.983 [1.349\u20132.224] L\/min\/mmHg; Caucasians: 2.227 [1.698\u20133.071] L\/min\/mmHg;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.2167). Tibetans showed a significantly lower HVRr (Tibetans: 0.001 [\u22120.211\u20130.074] L\/min\/%\/kg; Caucasians: 0.384 [0.160\u20130.637] L\/min\/%\/kg;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0112) and a blunted HVRe (Tibetans: 0.311 [0.225\u20130.789] L\/min\/%\/kg; Caucasians: 0.806 [0.518\u20131.196] L\/min\/%\/kg;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0448). These results indicate that Tibetan ancestry is associated with a partial protection from hypoxia\u2010induced central sleep apnea, likely related to a blunted hypoxic ventilatory response. These findings suggest that inherited differences in ventilatory control may modulate breathing stability during sleep at high altitude.\n                  <\/jats:p>","DOI":"10.1111\/jsr.70346","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T02:06:23Z","timestamp":1778033183000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Tibetan Ancestry on Respiratory Control and Central Sleep Apnea in Hypoxia"],"prefix":"10.1111","volume":"35","author":[{"given":"Gr\u00e9gory","family":"Heiniger","sequence":"first","affiliation":[{"name":"Center for Investigation and Research in Sleep Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise","family":"Piquilloud","sequence":"additional","affiliation":[{"name":"Adult Intensive Care Unit Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7135-133X","authenticated-orcid":false,"given":"Geoffroy","family":"Solelhac","sequence":"additional","affiliation":[{"name":"Center for Investigation and Research in Sleep Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Th\u00e9o","family":"Imler","sequence":"additional","affiliation":[{"name":"Center for Investigation and Research in Sleep Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien","family":"Waeber","sequence":"additional","affiliation":[{"name":"Center for Investigation and Research in Sleep Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Bradley","sequence":"additional","affiliation":[{"name":"Center for Investigation and Research in Sleep Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianpaolo","family":"Lecciso","sequence":"additional","affiliation":[{"name":"Center for Investigation and Research in Sleep Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Degache","sequence":"additional","affiliation":[{"name":"Institute of Sport Sciences University of Lausanne (ISSUL) University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alban","family":"Lovis","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karma","family":"Lambercy","sequence":"additional","affiliation":[{"name":"Head and Neck Surgery Department Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengt","family":"Kayser","sequence":"additional","affiliation":[{"name":"Institute of Sport Sciences University of Lausanne (ISSUL) University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Sands","sequence":"additional","affiliation":[{"name":"Division of Sleep and Circadian Disorders Brigham and Women's Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Wellman","sequence":"additional","affiliation":[{"name":"Division of Sleep and Circadian Disorders Brigham and Women's Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Heinzer","sequence":"additional","affiliation":[{"name":"Center for Investigation and Research in Sleep Lausanne University Hospital and University of Lausanne  Lausanne 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