{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:01:54Z","timestamp":1790622114553,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Emerging evidence links COVID\u201019 to the predisposition of Parkinson's disease (PD). However, the relationship between long COVID and prodromal PD\u2010like features remains unclear, particularly in long COVID participants with dream\u2010enactment behaviours (DEBs) that may be suggestive of possible REM sleep behaviour disorder. This study aimed to quantify the burden of prodromal PD\u2010like features in long COVID. This online survey (May\u2013Nov 2021) across 16 countries\/regions included 11,261 participants. Data on demographics, COVID\u201019 diagnosis, long COVID symptoms, sleep features and other typical prodromal PD\u2010like features were collected. The likelihood ratio (LR) of prodromal PD was calculated as a proxy for each participant's overall burden of prodromal PD\u2010like features, based on the 2019 Movement Disorder Society research criteria. Participants with long COVID (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091155) exhibited more symptoms suggestive of prodromal PD\u2010like features, including DEBs, olfactory dysfunctions, constipation, excessive daytime sleepiness, postural dizziness, depression with\/without anxiety, urinary dysfunctions, cognitive impairment and a higher LR of prodromal PD when compared to non\u2010COVID\u201019 participants and COVID\u201019 recoverees. Long COVID was associated with a 73% higher burden of potential prodromal PD\u2010like features (adjusted odds ratio [aOR]\u2009=\u20091.73, 95% confidence interval [CI]\u2009=\u20091.57\u20131.90). Among those with long COVID, emergence or exacerbation of post\u2010infection DEBs further increased this burden by 38% (aOR\u2009=\u20091.38, 95% CI\u2009=\u20091.19\u20131.60). Our study suggested that long COVID is associated with an increased burden of prodromal PD\u2010like features, which appears to be further enhanced with DEBs.\n                  <\/jats:p>","DOI":"10.1111\/jsr.70371","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T04:55:30Z","timestamp":1780289730000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Prodromal Parkinson's Disease\u2010Like Features in Long\n                    <scp>COVID<\/scp>\n                    With Dream\u2010Enactment Behaviours"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3182-0568","authenticated-orcid":false,"given":"Siyi","family":"Gong","sequence":"first","affiliation":[{"name":"Li Chiu Kong Family Sleep Assessment Unit, Department of Psychiatry, Faculty of Medicine The Chinese University of Hong Kong  Hong Kong SAR 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Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7051-745X","authenticated-orcid":false,"given":"Bj\u00f8rn","family":"Bjorvatn","sequence":"additional","affiliation":[{"name":"Department of Global Public Health and Primary Care University of Bergen, Norway and Norwegian Competence Centre for Sleep Disorders  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilona","family":"Merikanto","sequence":"additional","affiliation":[{"name":"Sleep Well Research Program, Faculty of Medicine University of Helsinki  Helsinki Finland"},{"name":"Orton Orthopedics Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3613-6631","authenticated-orcid":false,"given":"Luigi","family":"De Gennaro","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Rome  Rome 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