{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:00:36Z","timestamp":1790622036992,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"published-print":{"date-parts":[[2026,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Narcolepsy type I is a rare neurological sleep disorder characterised by chronic excessive daytime sleepiness, cataplexy, and low orexin (hypocretin) levels. Infection with\n SARS<\/jats:styled-content>\n \u2010\n CoV<\/jats:styled-content>\n \u20102 has been linked to neurological and neuropsychiatric sequelae, but cases of post\u2010\n COVID<\/jats:styled-content>\n narcolepsy remain extremely uncommon. We report a previously healthy 42\u2010year\u2010old Caucasian female who developed excessive daytime sleepiness, cataplexy, and hypnagogic\/hypnopompic hallucinations within 3\u2009months of confirmed\n SARS<\/jats:styled-content>\n \u2010\n CoV<\/jats:styled-content>\n \u20102 infection. Polysomnography (\n PSG<\/jats:styled-content>\n ) showed disturbed nocturnal sleep with a high arousal index and periodic limb movements and mild sleep apnea, while the multiple sleep latency test (\n MSLT<\/jats:styled-content>\n ) showed a mean latency of 1\u2009min with sleep\u2010onset rapid eye movement (\n REM<\/jats:styled-content>\n ) periods in all naps. Cerebrospinal fluid hypocretin was markedly reduced (<\u200940\u2009ng\/L), confirming narcolepsy type I. Following the diagnosis, medical treatment was initiated\u2014with methylphenidate for hypersomnolence followed by venlafaxine for cataplexy, which led to a substantial symptomatic improvement, enabling a return to daily functioning. The case contributes to the minimal literature on narcolepsy following\n COVID<\/jats:styled-content>\n \u201019 and supports hypotheses of autoimmune\u2010mediated destruction of hypocretin\u2010producing neurons triggered by viral infection. Clinicians should maintain a high index of suspicion for primary sleep disorders in patients with persistent fatigue and hypersomnolence after\n COVID<\/jats:styled-content>\n \u201019, as early recognition and targeted treatment markedly improve outcomes.\n <\/jats:p>","DOI":"10.1111\/jsr.70372","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:09:41Z","timestamp":1780103381000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["COVID<\/scp>\n \u201019\u2013Induced Narcolepsy Type\n I<\/scp>\n With Cataplexy: A Short Report"],"prefix":"10.1111","volume":"35","author":[{"given":"Torsten Vinding","family":"Merinder","sequence":"first","affiliation":[{"name":"Department of Neurology Viborg Regional Hospital Viborg Denmark"},{"name":"Department of Clinical Neurophysiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Langeskov\u2010Christensen","sequence":"additional","affiliation":[{"name":"Department of Neurology Viborg Regional Hospital Viborg Denmark"},{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"Kirov","sequence":"additional","affiliation":[{"name":"Department of Neurology Viborg Regional Hospital Viborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"e_1_2_14_2_1","volume-title":"International Classification of Sleep Disorders","author":"American Academy of Sleep Medicine","year":"2023"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(07)60237\u20102"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(20)30221\u20100"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2022.06.011"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201004049\u20106"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2011.09.003"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2020.1719832"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.14406"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(14)70218\u20102"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2013.04.013"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883\u2010022\u201002940\u20107"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(14)70075\u20104"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2013.09.021"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1500587"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215\u20100366(21)00084\u20105"}],"container-title":["Journal of Sleep Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsr.70372","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jsr.70372","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsr.70372","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:11:30Z","timestamp":1790619090000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jsr.70372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,29]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/jsr.70372"],"URL":"https:\/\/doi.org\/10.1111\/jsr.70372","archive":["Portico"],"relation":{},"ISSN":["0962-1105","1365-2869"],"issn-type":[{"value":"0962-1105","type":"print"},{"value":"1365-2869","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,29]]},"assertion":[{"value":"2025-11-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70372"}}