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To identify whether these associations are potentially causal, we conducted phenome\u2010wide Mendelian randomisation analyses of short sleep, insomnia symptoms, total sleep duration, long sleep, snoring, daytime sleepiness and morning chronotype with a broad range of health\u2010related phenotypes. We assessed the association between the genetic predisposition to these traits and the occurrence of 702 health\u2010related phenotypes, using summary statistics of the largest genome\u2010wide association studies in European individuals. Results that were significant (multiple comparisons: False Discovery Rate) and valid (robust genetic instruments, unaffected by horizontal pleiotropy) were validated using data from the second largest European genome\u2010wide association study. Genetically determined short sleep was associated with increased risks of attention\u2010deficit\/hyperactivity disorder and neuroticism, musculoskeletal conditions, asthma and gastroesophageal reflux and lower educational attainment. Genetically determined insomnia symptoms showed associations with increased risk of coronary artery disease, major depression and osteoarticular disease. Genetically determined long sleep was linked to higher risk of iron deficiency anaemia and lower bone mineral density. Genetic predisposition to snoring was associated with more falls, greater body mass and higher low\u2010grade inflammation. Genetically determined morning chronotype was related to higher vitamin D levels and lower risk of irritable bowel syndrome. No associations were found for daytime sleepiness. Overall, these findings indicate that genetically determined short sleep duration and insomnia symptoms are associated with mental and neurological problems, cardiovascular disease and musculoskeletal disorders, suggesting a potentially preventive, causal role of healthy sleeping patterns on chronic disease.<\/jats:p>","DOI":"10.1111\/jsr.70411","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T08:53:11Z","timestamp":1785228791000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sleep\u2010Related and Chronobiology Traits and Health\u2010Related Phenotypes: A Phenome\u2010Wide Mendelian Randomisation Study"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6983-413X","authenticated-orcid":false,"given":"Marta H.","family":"Hernandez","sequence":"first","affiliation":[{"name":"Blanquerna Faculty of Health Sciences University Ramon Llull  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9340-2708","authenticated-orcid":false,"given":"Camille","family":"Lassale","sequence":"additional","affiliation":[{"name":"ISGlobal  Barcelona Spain"},{"name":"Universitat Pompeu Fabra  Barcelona Spain"},{"name":"CIBER de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBEROBN) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9644-8421","authenticated-orcid":false,"given":"Anna","family":"Camps\u2010Vilar\u00f3","sequence":"additional","affiliation":[{"name":"Registre Giron\u00ed del Cor (REGICOR) Study Group Hospital del Mar Research Institute (IMIM)  Barcelona Spain"},{"name":"CIBER de Enfermedades Cardiovasculares (CIBERCV) Instituto de Salud Carlos III  Madrid Spain"},{"name":"Faculty of Medicine University of Vic\u2010Central University of Catalonia (UVic\u2010UCC)  Vic 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Study Group Hospital del Mar Research Institute (IMIM)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5026-4162","authenticated-orcid":false,"given":"Eleonora","family":"Fornara","sequence":"additional","affiliation":[{"name":"Blanquerna Faculty of Health Sciences University Ramon Llull  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3834-7101","authenticated-orcid":false,"given":"Elena","family":"Carrillo\u2010\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Blanquerna Faculty of Health Sciences University Ramon Llull  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5615-7961","authenticated-orcid":false,"given":"Mar\u00eda Fernanda","family":"Zer\u00f3n\u2010Rugerio","sequence":"additional","affiliation":[{"name":"Nutrition and Food Safety Research Institute (INSA\u2010UB) University of Barcelona  Santa Coloma de Gramenet Spain"},{"name":"Department of Fundamental and Clinical Nursing, Faculty of Nursing University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Izquierdo\u2010Pulido","sequence":"additional","affiliation":[{"name":"Nutrition and Food Safety Research Institute (INSA\u2010UB) University of Barcelona  Santa Coloma de Gramenet Spain"},{"name":"Department of Nutrition, Food Science, and Gastronomy University of Barcelona  Santa Coloma de Gramenet Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6860-1556","authenticated-orcid":false,"given":"Maria","family":"Gil\u2010Vives","sequence":"additional","affiliation":[{"name":"Grup d'Enginyeria de Materials (Gemat) Universitat Ramon Llull, Institut Qu\u00edmic de Sarri\u00e0  Barcelona 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