{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T06:15:04Z","timestamp":1788416104473,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["DUT24LAB119"],"award-info":[{"award-number":["DUT24LAB119"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Obstructive sleep apnoea (OSA) is a common chronic multisystem disorder, and cortical structural alterations have been detected via conventional neuroimaging techniques. Recent advances in diffusion\u2010weighted imaging have yielded novel techniques for investigating neural microstructure, which may potentially offer supplementary insights into neurodegenerative processes associated with OSA. In the present study, we employed the neurite orientation dispersion and density imaging (NODDI) model to explore cortical microstructure in patients with OSA. Multi\u2010shell diffusion magnetic resonance imaging (MRI) was acquired to fit the NODDI diffusion models. Scanned participants included individuals with mild OSA (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200924), moderate OSA (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200926), severe OSA (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200923) and healthy controls (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200924). Grey matter\u2010based spatial statistics (GBSS) were used to compare NODDI\u2010derived microstructural measures, orientation dispersion index (ODI) and neurite density index (NDI), among the four groups. The results demonstrated significant alterations (both increases and decreases) in NODDI metrics across OSA groups with different severity levels, with relatively more pronounced and widespread ODI changes observed compared with those of NDI. Our findings suggest a potential association between OSA and widespread alterations in grey matter cytoarchitecture. Neurite parameters provide important insights into the microstructure of grey matter in OSA.\n                  <\/jats:p>","DOI":"10.1111\/jsr.70444","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:32:52Z","timestamp":1788413572000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neurite Imaging Reveals Widespread Alterations in Grey Matter Neurite Morphology in Obstructive Sleep Apnoea"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3109-2353","authenticated-orcid":false,"given":"Liping","family":"Qi","sequence":"first","affiliation":[{"name":"School of Control Science and Engineering Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0871-0977","authenticated-orcid":false,"given":"Qiu","family":"Chu","sequence":"additional","affiliation":[{"name":"School of Information and Communication Engineering Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9463-5397","authenticated-orcid":false,"given":"Ya\u2010Jie","family":"Liu","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Dalian Medical University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong\u2010Hua","family":"Li","sequence":"additional","affiliation":[{"name":"School of Control Science and Engineering Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Wen","sequence":"additional","affiliation":[{"name":"Chongqing's Changshou District Mental Health Center  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Zhong","family":"Lin","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Dalian 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