{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T05:18:32Z","timestamp":1787980712908,"version":"build-2784847793"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004795","name":"Institut Universitaire de France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006451","name":"Hospices Civils de Lyon","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006451","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Sleep deprivation (SD) compromises declarative memory encoding and subsequent consolidation, yet its consequences for the acquisition of new motor skill learning remain unknown. Forty\u2010eight healthy adults underwent either one night of total SD or normal sleep and were tested the next morning using a multimodal approach combining psychomotor vigilance, subjective sleepiness, cortisol, brain\u2010derived neurotrophic factor (BDNF), and corticospinal excitability, alongside a standardised explicit motor sequence learning task dissociating goal\u2010based accuracy from movement\u2010based execution speed. SD induced a marked psychophysiological stress state\u2014elevated cortisol, reduced vigilance, and increased sleepiness\u2014without altering BDNF levels or brain excitability. Motor learning elicited the expected intracortical disinhibition across groups, yet SD did not modulate BDNF or corticospinal excitability following skill acquisition. The main findings showed that SD selectively reduced movement time gains during acquisition while sparing spatial accuracy, revealing a dissociation between motor execution efficiency and goal representation. Importantly, this selective alteration did not persist beyond training, as delayed consolidation (24\u2009Hours and 7\u2009Days) remained preserved. Together, these findings provide the first direct evidence of a component\u2010specific vulnerability of sequential motor learning to a full night of SD in the absence of detectable alterations in plasticity\u2010related markers.<\/jats:p>","DOI":"10.1111\/jsr.70445","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:46:11Z","timestamp":1787791571000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Motor Sequence Learning Under Sleep Deprivation"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0414-7444","authenticated-orcid":false,"given":"Guillaume","family":"Digonet","sequence":"first","affiliation":[{"name":"Laboratoire Interuniversitaire de Biologie de la Motricit\u00e9 (LIBM) Universite Claude Bernard Lyon 1 (UCBL1)  Villeurbanne France"},{"name":"Laboratoire Interuniversitaire de Biologie de la Motricit\u00e9 Universit\u00e9 Jean Monnet Saint\u2010Etienne, Lyon 1 Universit\u00e9 Savoie Mont\u2010Blanc  Saint\u2010Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1477-6614","authenticated-orcid":false,"given":"Thomas","family":"Lapole","sequence":"additional","affiliation":[{"name":"Laboratoire Interuniversitaire de Biologie de la Motricit\u00e9 Universit\u00e9 Jean Monnet Saint\u2010Etienne, Lyon 1 Universit\u00e9 Savoie Mont\u2010Blanc  Saint\u2010Etienne France"},{"name":"Institut Universitaire de France  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliette","family":"G\u00e9l\u00e9bart","sequence":"additional","affiliation":[{"name":"Laboratoire Interuniversitaire de Biologie de la Motricit\u00e9 (LIBM) Universite Claude Bernard Lyon 1 (UCBL1)  Villeurbanne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0789-6140","authenticated-orcid":false,"given":"J\u00e9r\u00e9mie","family":"Bouvier","sequence":"additional","affiliation":[{"name":"Laboratoire Interuniversitaire de Biologie de la Motricit\u00e9 (LIBM) Universite Claude Bernard Lyon 1 (UCBL1)  Villeurbanne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"Prudent","sequence":"additional","affiliation":[{"name":"Exploration Fonctionnelle Respiratoire, M\u00e9decine du Sport et de l'Activit\u00e9 Physique Hospices Civils de Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2057-061X","authenticated-orcid":false,"given":"Vincent","family":"Pialoux","sequence":"additional","affiliation":[{"name":"Laboratoire Interuniversitaire de Biologie de la Motricit\u00e9 (LIBM) Universite Claude Bernard Lyon 1 (UCBL1)  Villeurbanne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Pingon","sequence":"additional","affiliation":[{"name":"Exploration Fonctionnelle Respiratoire, M\u00e9decine du Sport et de l'Activit\u00e9 Physique Hospices Civils de Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emeric","family":"Stauffer","sequence":"additional","affiliation":[{"name":"Laboratoire Interuniversitaire de Biologie de la Motricit\u00e9 (LIBM) Universite Claude Bernard Lyon 1 (UCBL1)  Villeurbanne France"},{"name":"Exploration Fonctionnelle Respiratoire, M\u00e9decine du Sport et de l'Activit\u00e9 Physique Hospices Civils de Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9628-2350","authenticated-orcid":false,"given":"Ursula","family":"Debarnot","sequence":"additional","affiliation":[{"name":"Laboratoire Interuniversitaire de Biologie de la Motricit\u00e9 (LIBM) Universite Claude Bernard Lyon 1 (UCBL1)  Villeurbanne France"},{"name":"Institut Universitaire de France  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.02.008"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059490"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.71.6.809"},{"key":"e_1_2_11_5_1","first-page":"27","volume-title":"Progress in Brain Research","author":"Cousins J. 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