{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T08:16:42Z","timestamp":1787991402986,"version":"build-2784847793"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Sleep bruxism (SB) is a motor activity characterized by repetitive masticatory muscle contractions during sleep, commonly associated with tooth damage and jaw pain or headache. Pharmacological management strategies targeting its central nervous system\u2010related mechanisms remain limited. This study aimed to evaluate whether a low dose of a central muscle relaxant, cyclobenzaprine, reduces SB\u2010related muscle activity, maximum voluntary bite force and self\u2010reported bruxism awareness. A randomized, double\u2010blind, placebo\u2010controlled, crossover clinical trial was conducted. Twenty participants underwent baseline SB motor activity recordings followed by two intervention phases consisting of 5\u2009mg of cyclobenzaprine or placebo for three consecutive nights. Masticatory muscle activity during sleep was quantified using portable surface electromyography. Maximum voluntary bite force was measured using a bite force\u2010recording device. Self\u2010reported outcomes related to SB and secondary effects (e.g., dry mouth) were collected each morning. Comparison of cyclobenzaprine to placebo and baseline nights failed to show a difference in mean frequency of masticatory muscle activity during sleep and maximum voluntary bite force. No self\u2010reported differences were observed for SB awareness. Few secondary effects were identified between cyclobenzaprine use and placebo; a significant increase in perception of tolerable dry mouth upon awakening (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.034) and a marginally statistically significant reduction in the perceived leg movements during sleep (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.046). In conclusion, low\u2010dose cyclobenzaprine was not effective in modifying SB\u2013related muscle activity or masticatory muscle force, suggesting limited clinical utility for SB. Future studies using higher doses of cyclobenzaprine are warranted before ruling out its clinical utility, within a safety profile.\n                  <\/jats:p>","DOI":"10.1111\/jsr.70446","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T07:36:26Z","timestamp":1787988986000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lack of Efficacy of Low\u2010Dose Cyclobenzaprine on Electromyographic Activity Related to Sleep Bruxism: A Randomized Crossover Double\u2010Blind Placebo\u2010Controlled Clinical Trial"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2829-9505","authenticated-orcid":false,"given":"Matheus","family":"Herreira\u2010Ferreira","sequence":"first","affiliation":[{"name":"Bauru School of Dentistry University of S\u00e3o Paulo  Bauru Brazil"},{"name":"Ribeir\u00e3o Preto School of Dentistry University of S\u00e3o Paulo  Ribeir\u00e3o Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0424-9076","authenticated-orcid":false,"given":"Cibele Dal","family":"Fabbro","sequence":"additional","affiliation":[{"name":"Faculty of Dental Medicine Universite de Montreal  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3041-8099","authenticated-orcid":false,"given":"Gilles J.","family":"Lavigne","sequence":"additional","affiliation":[{"name":"Faculty of Dental Medicine and Oral Health Sciences McGill University  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7805-5672","authenticated-orcid":false,"given":"Juliana","family":"Stuginski\u2010Barbosa","sequence":"additional","affiliation":[{"name":"Instituto de Ensino Odontol\u00f3gico Bauru Orofacial Pain Group  Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9524-8089","authenticated-orcid":false,"given":"Peter","family":"Svensson","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry National University of Singapore and National University Centre for Oral Health  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0413-4658","authenticated-orcid":false,"given":"Paulo C\u00e9sar Rodrigues","family":"Conti","sequence":"additional","affiliation":[{"name":"Bauru School of Dentistry University of S\u00e3o Paulo  Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0080-7678","authenticated-orcid":false,"given":"Leonardo Rigoldi","family":"Bonjardim","sequence":"additional","affiliation":[{"name":"Bauru School of Dentistry University of S\u00e3o Paulo  Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.12821"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149\u20102918(03)80067\u2010X"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.13.1613"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/33.12.1711"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.17219\/dmp\/156400"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.13061"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.15331\/jdsm.5114"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4378"},{"issue":"10","key":"e_1_2_11_10_1","first-page":"1313","article-title":"Centrally Acting Oral Skeletal Muscle Relaxants","volume":"37","author":"Elenbaas J. 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