{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T01:10:23Z","timestamp":1789089023625,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Obstructive sleep apnoea (OSA) is associated with major depressive disorder (MDD). However, limited data exist regarding the impact of continuous positive airway pressure (CPAP) on MDD incidence. Data from the Pays de la Loire Cohort were linked to health administrative data to identify incident MDD, defined by antidepressant prescription or hospitalisation for MDD, in patients with no history of psychiatric disorders (depressive, bipolar, psychotic and anxiety disorders) who were prescribed CPAP. Patients with documented CPAP use of at least 4\u2009h per night were compared to those with less than 4\u2009h of use. Cox proportional hazards models were used. After a median follow\u2010up of 8.45\u2009years, 561 (20.7%) of 2712 patients developed MDD, including 200 (24.2%) in the non\u2010adherent group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009827) and 361 (19.2%) in the adherent group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091885). CPAP adherence was associated with a reduced risk of MDD, even after adjusting for age, sex, BMI, socio\u2010professional factors, insomnia complaint and baseline depressive symptoms (HR\u2009=\u20090.83 [0.70\u20130.99],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.04). In a population free of prior all psychiatric disorders and treated for OSA with CPAP, adherence to therapy is associated with a lower incidence of MDD. Further studies are warranted to clarify whether non\u2010adherent patients display vulnerability factors\u2014such as insomnia\u2014that may increase their risk of developing MDD.\n                  <\/jats:p>","DOI":"10.1111\/jsr.70452","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T01:00:56Z","timestamp":1789088456000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Continuous Positive Airway Pressure Therapy Adherence and Incident Depression Risk in Patients With Obstructive Sleep Apnoea"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6589-8064","authenticated-orcid":false,"given":"Julie","family":"Garrivet","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Addictology Angers University Hospital  Angers France"},{"name":"Department of Respiratory and Sleep Medicine Angers University Hospital  Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8382-4037","authenticated-orcid":false,"given":"Margaux","family":"Blanchard","sequence":"additional","affiliation":[{"name":"IRSRpl  Beaucouz\u00e9 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3613-4903","authenticated-orcid":false,"given":"B\u00e9n\u00e9dicte","family":"Gohier","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Addictology Angers University Hospital  Angers France"},{"name":"University of Angers, University of Nantes, LPPL, SFR CONFLUENCES  Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9121-209X","authenticated-orcid":false,"given":"Pierre A.","family":"Geoffroy","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Addictology, AP\u2010HP, GHU Paris Nord, DMU Neurosciences, Bichat\u2010Claude Bernard Hospital  Paris France"},{"name":"Universit\u00e9 Paris Cit\u00e9, NeuroDiderot, Inserm  Paris France"},{"name":"Centre ChronoS, GHU Paris\u2014Psychiatry &amp; Neurosciences  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7135-133X","authenticated-orcid":false,"given":"Geoffroy","family":"Solelhac","sequence":"additional","affiliation":[{"name":"Center for Investigation and Research in Sleep (CIRS), Lausanne University Hospital (CHUV) University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Jouvenot","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases Le Mans General Hospital  Le Mans France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Thomas","sequence":"additional","affiliation":[{"name":"Respiratory Unit P\u00f4le sant\u00e9 des Olonnes  Olonne sur Mer France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4231-5102","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric","family":"Gagnadoux","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Sleep Medicine Angers University Hospital  Angers France"},{"name":"INSERM Unit 1063  Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0426-3273","authenticated-orcid":false,"given":"Wojciech","family":"Trzepizur","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Sleep Medicine Angers University Hospital  Angers France"},{"name":"INSERM Unit 1063  Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S2213-2600(25)00002-5","article-title":"Positive Airway Pressure Therapy and All\u2010Cause and Cardiovascular Mortality in People With Obstructive Sleep Apnoea: A Systematic Review and Meta\u2010Analysis of Randomised Controlled Trials and Confounder\u2010Adjusted, Non\u2010Randomised Controlled Studies","volume":"13","author":"Benjafield A. V.","year":"2025","journal-title":"Lancet Respiratory Medicine"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/S0013-7006(17)30155-0","article-title":"Prise en Charge des Troubles D\u00e9pressifs R\u00e9sistants: Recommandations Fran\u00e7aises Formalis\u00e9es par des Experts de l'AFPBN et de la Fondation FondaMental","volume":"43","author":"Charpeaud T.","year":"2017","journal-title":"L'Enc\u00e9phale"},{"key":"e_1_2_10_4_1","first-page":"679","article-title":"Performing Pharmacoepidemiological Studies Using the French Health Insurance Data Warehouse (SNDS): How to Translate Guidelines Into Practice","volume":"78","author":"Germay S.","year":"2023","journal-title":"Th\u00e9rapie"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1007\/s11325-020-02266-z","article-title":"The Presence of Insomnia and Depression Contributes to the Acceptance of an Initial Treatment Trial of Continuous Positive Airway Pressure Therapy in Patients With Obstructive Sleep Apnea","volume":"25","author":"Drakou T.","year":"2021","journal-title":"Sleep & Breathing"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jeph.2024.202315","article-title":"Epid\u00e9miologie de la d\u00e9pression p\u00e9rinatale \u00e0 travers les donn\u00e9es du Syst\u00e8me national des donn\u00e9es de sant\u00e9 (SNDS)","volume":"72","author":"Ea E.","year":"2024","journal-title":"Journal of Epidemiology and Population Health"},{"key":"e_1_2_10_7_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.smrv.2024.101932","article-title":"The PAP\u2010RES Algorithm: Defining Who, Why and How to Use Positive Airway Pressure Therapy for OSA","volume":"75","author":"Gagnadoux F.","year":"2024","journal-title":"Sleep Medicine Reviews"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jad.2018.10.096","article-title":"Clinical Characteristics of Obstructive Sleep Apnea in Bipolar Disorders","volume":"245","author":"Geoffroy P. 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W.","year":"2024","journal-title":"Canadian Journal of Psychiatry"},{"key":"e_1_2_10_15_1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.5664\/jcsm.6546","article-title":"Associations of Undiagnosed Obstructive Sleep Apnea and Excessive Daytime Sleepiness With Depression: An Australian Population Study","volume":"13","author":"Lang C. J.","year":"2017","journal-title":"Journal of Clinical Sleep Medicine"},{"key":"e_1_2_10_16_1","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/s41380-018-0237-8","article-title":"Healthy Dietary Indices and Risk of Depressive Outcomes: A Systematic Review and Meta\u2010Analysis of Observational Studies","volume":"24","author":"Lassale C.","year":"2019","journal-title":"Molecular Psychiatry"},{"key":"e_1_2_10_17_1","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.chest.2024.05.024","article-title":"Association Between Healthy Behaviors and Health Care Resource Use With Subsequent Positive Airway Pressure Therapy Adherence in OSA","volume":"166","author":"Launois C.","year":"2024","journal-title":"Chest"},{"key":"e_1_2_10_18_1","volume-title":"Facteurs de risque des \u00e9pisodes d\u00e9pressifs en population g\u00e9n\u00e9rale","author":"Leroux I.","year":"2006"},{"key":"e_1_2_10_19_1","first-page":"134","article-title":"Effects of Insomnia and Depression on CPAP Adherence in a Military Population","volume":"36","author":"Mitzkewich M. 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