{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:05:41Z","timestamp":1790139941672,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["965417"],"award-info":[{"award-number":["965417"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Obstructive sleep apnoea (OSA) is common, but current diagnostic pathways rely on single\u2010night assessment and the apnoea\u2013hypopnoea index. Both are limited for assessment of variability and linking only weakly to symptoms, comorbidity and treatment response. The current protocol addresses this gap by aiming to validate a diagnostic pathway integrating a digital platform, mobile application, multiple\u2010night sleep testing, semiautomated analysis and a novel sleep health questionnaire, labelled as \u2018Sleep Revolution\u2019. Study objectives are to compare staff time required for diagnosis between standard care and Sleep Revolution pathway, and to examine associations between multi\u2010night sleep metrics and Positive Airway Pressure (PAP) treatment outcomes, diagnostic concordance, PAP prescription, patient satisfaction, adherence and feasibility. This multicentre, two\u2010arm cross\u2010over study is conducted at 23 sleep centres in Europe within the European Sleep Apnoea Database (ESADA) network. Adults referred for suspected OSA complete both standard care and the Sleep Revolution pathway in randomised order. Standard care includes single\u2010night polygraphy or polysomnography according to local routines. The Sleep Revolution pathway comprises three nights of self\u2010applied polysomnography (NOX\u2010SAS), digital symptom assessment (mobile app) and the Withings ScanWatch (physical activity, physiological signals). Diagnosis and treatment decisions are based solely on the first pathway. Outcomes include staff time (primary), technical performance, diagnostic yield, patient\u2010reported measures, PAP adherence and symptom change. The sample size is calculated as 1000 randomised participants. Ethical approval is obtained at all participating centres. The trial is registered with ISRCTN (ISRCTN17539031). Data acquisition is performed between Q1 2024 and Q2 2025; data cleaning and analyses are ongoing.<\/jats:p>","DOI":"10.1111\/jsr.70457","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:27:01Z","timestamp":1790137621000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Trial Protocol: A Randomised, Controlled Cross\u2010Over Trial Evaluating the Digital Sleep Revolution Diagnostic\u2010Therapeutic Pathway for Obstructive Sleep Apnoea"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7405-1682","authenticated-orcid":false,"given":"Ludger","family":"Grote","sequence":"first","affiliation":[{"name":"Centre for Sleep Research, Institute of Medicine, Sahlgrenska Academy Gothenburg University and Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0877-3529","authenticated-orcid":false,"given":"Erna Sif","family":"Arnardottir","sequence":"additional","affiliation":[{"name":"Sleep Institute, School of Technology Reykjavik University  Reykjav\u00edk Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8168-6611","authenticated-orcid":false,"given":"\u00d6zen K.","family":"Basoglu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Ege University School of Medicine  \u0130zmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4875-7796","authenticated-orcid":false,"given":"Maria R.","family":"Bonsignore","sequence":"additional","affiliation":[{"name":"PROMISE Department University of Palermo  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3138-3887","authenticated-orcid":false,"given":"Zoran","family":"Dogas","sequence":"additional","affiliation":[{"name":"Sleep Medicine Center, Department of Neuroscience University of Split School of Medicine  Split Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6773-3503","authenticated-orcid":false,"given":"Marta","family":"Drummond","sequence":"additional","affiliation":[{"name":"Respiratory Department and Sleep and Ventilation Unit Centro Hospitalare Universit\u00e1rio de S\u00e3o Jo\u00e3o  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8601-423X","authenticated-orcid":false,"given":"Francesco","family":"Fanfulla","sequence":"additional","affiliation":[{"name":"Respiratory Function and Sleep Unit Istituti Clinici Scientifici Maugeri IRCC, Istituto di Pavia e Montescano  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7299-7346","authenticated-orcid":false,"given":"Haralampos","family":"Gouveris","sequence":"additional","affiliation":[{"name":"Sleep Medicine and Neurostimulation Center, Department of Otorhinolaryngology University Medical Center Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Lombardi","sequence":"additional","affiliation":[{"name":"University of Milano Bicocca  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8897-8342","authenticated-orcid":false,"given":"Stefan","family":"Mihaicuta","sequence":"additional","affiliation":[{"name":"Centre for Research and Innovation in Precision Medicine of Respiratory Diseases, Department of Pulmonology \u201cVictor Babes\u201d University of Medicine and Pharmacy  Timi\u0219oara Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3252-6694","authenticated-orcid":false,"given":"Athanasia","family":"Pataka","sequence":"additional","affiliation":[{"name":"Respiratory Failure Unit, G. 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