{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T23:45:33Z","timestamp":1791762333319,"version":"4.3.4"},"reference-count":45,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Sleep Research"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The relationship between linear growth and obstructive sleep\u2010disordered breathing (SDB) has not been extensively studied. Hypoxic burden (HB) is a new metric that may better capture end\u2010organ damage in paediatric SDB compared to the traditional apnea\u2010hypopnea index (AHI). This observational cross\u2010sectional study examined the association between HB and linear growth in nonobese children aged 3\u20139\u2009years with SDB. HB was assessed as the area under the peripheral oxygen desaturation curve, alongside standard polysomnography indices. A cohort of 164 children without comorbidities except for asthma was evaluated for suspected SDB, with demographic and anthropometric data collected. The mean\u2009\u00b1\u2009standard deviation height\n                    <jats:italic>z<\/jats:italic>\n                    score was \u22120.05\u2009\u00b1\u20091.09, and the median [25th; 75th percentile] HB was 1.4 [0.4; 3.5] %min\/h. Forty children (24%) had an obstructive AHI greater than 5\/h. HB and frequent snoring (\u2265\u20093 nights\/week) were significantly and negatively associated with height\n                    <jats:italic>z<\/jats:italic>\n                    score (standardized\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u2009\u22120.21,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.036 and \u22120.37,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.043, respectively), whereas AHI did not predict linear growth outcomes. In multivariate analyses, HB remained independently associated with lower height\n                    <jats:italic>z<\/jats:italic>\n                    score and accounted for 7.5% of its variance, compared with 12.7% for ethnicity and 6.4% for body mass index\n                    <jats:italic>z<\/jats:italic>\n                    score. The oxygen desaturation index was also a significant predictor, but it explained less variance in height\n                    <jats:italic>z<\/jats:italic>\n                    score than HB. These findings suggest that intermittent hypoxia may contribute to impaired linear growth in children with SDB, although its contribution is modest and other determinants of growth remain important.\n                  <\/jats:p>","DOI":"10.1111\/jsr.70477","type":"journal-article","created":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T23:16:41Z","timestamp":1791760601000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hypoxic Burden Is an Important Determinant of Height in Nonobese Children With Sleep\u2010Disordered Breathing"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0604-2482","authenticated-orcid":false,"given":"Plamen","family":"Bokov","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris\u2010Cit\u00e9, AP\u2010HP, H\u00f4pital Robert Debr\u00e9, Service de Physiologie P\u00e9diatrique\u2010Centre du Sommeil, INSERM NeuroDiderot  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0827-616X","authenticated-orcid":false,"given":"Benjamin","family":"Dudoignon","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Cit\u00e9, AP\u2010HP, H\u00f4pital Robert Debr\u00e9, Service de Physiologie P\u00e9diatrique\u2010Centre du Sommeil, INSERM NeuroDiderot  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2786-0812","authenticated-orcid":false,"given":"Christophe","family":"Delclaux","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Cit\u00e9, AP\u2010HP, H\u00f4pital Robert Debr\u00e9, Service de Physiologie P\u00e9diatrique\u2010Centre du Sommeil, INSERM NeuroDiderot  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,11]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.78.5.1195"},{"key":"e_1_2_13_3_1","volume-title":"The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology, and Technical Specifications","author":"Berry R. B.","year":"2017"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.72.1854.44"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2023.02.016"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.70211"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsad170"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.141192"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2010.11.010"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(16)36806-7"},{"key":"e_1_2_13_11_1","first-page":"1495","article-title":"Overnight Growth Hormone Secretion in Short Children: Independence of the Sleep Pattern","volume":"77","author":"Buzi F.","year":"1993","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2018.03.001"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/NSS.S475390"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2012.07.001"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119207"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2025.05.039"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.6868"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2007.04.013"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.58.1.23"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.65.1.119"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-8-4-426"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.5672"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599810392328"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00385-2015"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2021.100977"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2024.2554"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200708-135MG"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-1671"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(94)70007-9"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1390023"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.4.e55"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyq180"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2018.01.001"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2011.01.019"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12398"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.3109\/03014460903049074"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.165.3892.513"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2010.11.011"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-3164"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.70032"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2011.07.007"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2023.2145"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.359"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/33.9.1165"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00652.2013"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2013.08.801"}],"container-title":["Journal of Sleep Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsr.70477","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jsr.70477","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jsr.70477","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T23:16:42Z","timestamp":1791760602000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jsr.70477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,11]]},"references-count":45,"alternative-id":["10.1111\/jsr.70477"],"URL":"https:\/\/doi.org\/10.1111\/jsr.70477","archive":["Portico"],"relation":{},"ISSN":["0962-1105","1365-2869"],"issn-type":[{"value":"0962-1105","type":"print"},{"value":"1365-2869","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,11]]},"assertion":[{"value":"2026-01-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70477"}}