{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:18:56Z","timestamp":1791296336810,"version":"4.1.0"},"reference-count":98,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T00:00:00Z","timestamp":1670284800000},"content-version":"vor","delay-in-days":3657,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1111\/jth.12009","type":"journal-article","created":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T01:40:38Z","timestamp":1349055638000},"page":"2418-2427","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":87,"title":["The future of glycoprotein\u00a0VI as an antithrombotic target"],"prefix":"10.1016","volume":"10","author":[{"given":"M.","family":"ZAHID","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"MANGIN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"LOYAU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"HECHLER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"BILLIALD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"GACHET","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"JANDROT\u2010PERRUS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/jth.12009_bb0010","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/nrcardio.2011.96","article-title":"The evolution of antiplatelet therapy in cardiovascular disease","volume":"8","author":"Yousuf","year":"2011","journal-title":"Nat Rev Cardiol"},{"key":"10.1111\/jth.12009_bb0015","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/WCO.0b013e328341f8d6","article-title":"Reperfusion therapy in acute cerebrovascular syndrome","volume":"24","author":"Mazighi","year":"2011","journal-title":"Curr Opin Neurol"},{"key":"10.1111\/jth.12009_bb0020","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0140-6736(04)16721-4","article-title":"Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high\u2010risk patients (MATCH): randomised, double\u2010blind, placebo\u2010controlled trial","volume":"364","author":"Diener","year":"2004","journal-title":"Lancet"},{"key":"10.1111\/jth.12009_bb0025","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1056\/NEJMoa060989","article-title":"Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events","volume":"354","author":"Bhatt","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1111\/jth.12009_bb0030","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nrd1198","article-title":"Antiplatelet therapy: in search of the \u2018magic bullet\u2019","volume":"2","author":"Jackson","year":"2003","journal-title":"Nat Rev Drug Discov"},{"key":"10.1111\/jth.12009_bb0035","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1055\/s-0030-1251505","article-title":"Diagnostic and therapeutic potentials of platelet glycoprotein\u00a0VI","volume":"36","author":"Bigalke","year":"2010","journal-title":"Semin Thromb Hemost"},{"key":"10.1111\/jth.12009_bb0040","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1182\/blood.V69.6.1712.1712","article-title":"A novel platelet aggregating factor found in a patient with defective collagen\u2010induced platelet aggregation and autoimmune thrombocytopenia","volume":"69","author":"Sugiyama","year":"1987","journal-title":"Blood"},{"key":"10.1111\/jth.12009_bb0045","doi-asserted-by":"crossref","first-page":"23528","DOI":"10.1074\/jbc.272.38.23528","article-title":"A novel association of Fc receptor gamma\u2010chain with glycoprotein\u00a0VI and their co\u2010expression as a collagen receptor in human platelets","volume":"272","author":"Tsuji","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.12009_bb0050","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0014-5793(97)00926-5","article-title":"Glycoprotein\u00a0VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor gamma\u2010chain","volume":"413","author":"Gibbins","year":"1997","journal-title":"FEBS Lett"},{"key":"10.1111\/jth.12009_bb0055","doi-asserted-by":"crossref","first-page":"27035","DOI":"10.1074\/jbc.272.43.27035","article-title":"Adhesion and activation of human platelets induced by convulxin involve glycoprotein\u00a0VI and integrin alpha2beta1","volume":"272","author":"Jandrot\u2010Perrus","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.12009_bb0060","doi-asserted-by":"crossref","first-page":"13576","DOI":"10.1074\/jbc.272.21.13576","article-title":"Platelet activation and signal transduction by convulxin, a C\u2010type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62\/GPVI collagen receptor","volume":"272","author":"Polgar","year":"1997","journal-title":"J Biol Chem"},{"issue":"Pt 2","key":"10.1111\/jth.12009_bb0065","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1042\/bj3390413","article-title":"Monomeric (glycine\u2010proline\u2010hydroxyproline)10 repeat sequence is a partial agonist of the platelet collagen receptor glycoprotein\u00a0VI","volume":"339","author":"Asselin","year":"1999","journal-title":"Biochem J"},{"key":"10.1111\/jth.12009_bb0070","doi-asserted-by":"crossref","first-page":"29019","DOI":"10.1074\/jbc.274.41.29019","article-title":"The platelet collagen receptor glycoprotein\u00a0VI is a member of the immunoglobulin superfamily closely related to FcalphaR and the natural killer receptors","volume":"274","author":"Clemetson","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.12009_bb0075","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1182\/blood.V96.5.1798","article-title":"Cloning, characterization, and functional studies of human and mouse glycoprotein\u00a0VI: a platelet\u2010specific collagen receptor from the immunoglobulin superfamily","volume":"96","author":"Jandrot\u2010Perrus","year":"2000","journal-title":"Blood"},{"key":"10.1111\/jth.12009_bb0080","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0049-3848(00)00182-1","article-title":"Cloning and expression of the platelet\u2010specific collagen receptor glycoprotein\u00a0VI","volume":"98","author":"Miura","year":"2000","journal-title":"Thromb Res"},{"key":"10.1111\/jth.12009_bb0085","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1182\/blood-2006-01-010215","article-title":"Structural basis for platelet collagen responses by the immune\u2010type receptor glycoprotein\u00a0VI","volume":"108","author":"Horii","year":"2006","journal-title":"Blood"},{"key":"10.1111\/jth.12009_bb0090","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1161\/01.ATV.0000137974.85068.93","article-title":"Principal role of glycoprotein\u00a0VI in alpha2beta1 and alphaIIbbeta3 activation during collagen\u2010induced thrombus formation","volume":"24","author":"Lecut","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1111\/jth.12009_bb0095","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1182\/blood-2003-01-0308","article-title":"Identification of the primary collagen\u2010binding surface on human glycoprotein\u00a0VI by site\u2010directed mutagenesis and by a blocking phage antibody","volume":"103","author":"Smethurst","year":"2004","journal-title":"Blood"},{"key":"10.1111\/jth.12009_bb0100","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.1182\/blood-2005-04-1454","article-title":"The influence of N\u2010linked glycosylation on the function of platelet glycoprotein\u00a0VI","volume":"106","author":"Kunicki","year":"2005","journal-title":"Blood"},{"key":"10.1111\/jth.12009_bb0105","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1111\/j.1538-7836.2005.01764.x","article-title":"Gain\u2010 and loss\u2010of\u2010function mutants confirm the importance of apical residues to the primary interaction of human glycoprotein\u00a0VI with collagen","volume":"4","author":"O\u2019Connor","year":"2006","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.12009_bb0110","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.jmb.2006.06.053","article-title":"Chimeric Fc receptors identify ligand binding regions in human glycoprotein\u00a0VI","volume":"361","author":"Dumont","year":"2006","journal-title":"J Mol Biol"},{"key":"10.1111\/jth.12009_bb0115","doi-asserted-by":"crossref","first-page":"33505","DOI":"10.1074\/jbc.M606480200","article-title":"Selective blockade of glycoprotein\u00a0VI clustering on collagen helices","volume":"281","author":"O\u2019Connor","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.12009_bb0120","doi-asserted-by":"crossref","first-page":"46197","DOI":"10.1074\/jbc.M204029200","article-title":"Analysis of the interaction of platelet collagen receptor glycoprotein\u00a0VI (GPVI) with collagen. A dimeric form of GPVI, but not the monomeric form, shows affinity to fibrous collagen","volume":"277","author":"Miura","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.12009_bb0125","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1111\/j.1538-7836.2009.03496.x","article-title":"Glycoprotein (GP)\u00a0VI dimer as a major collagen\u2010binding site of native platelets: direct evidence obtained with dimeric GPVI\u2010specific Fabs","volume":"7","author":"Jung","year":"2009","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.12009_bb0130","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1161\/ATVBAHA.111.241067","article-title":"Platelet glycoprotein\u00a0VI dimerization, an active process inducing receptor competence, is an indicator of platelet reactivity","volume":"32","author":"Loyau","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1111\/jth.12009_bb0135","doi-asserted-by":"crossref","first-page":"3611","DOI":"10.1182\/blood-2004-04-1549","article-title":"Regulation of platelet membrane levels of glycoprotein\u00a0VI by a platelet\u2010derived metalloproteinase","volume":"104","author":"Gardiner","year":"2004","journal-title":"Blood"},{"key":"10.1111\/jth.12009_bb0140","doi-asserted-by":"crossref","first-page":"4311","DOI":"10.1182\/blood-2011-10-386607","article-title":"Pathologic shear triggers shedding of vascular receptors: a novel mechanism for down\u2010regulation of platelet glycoprotein\u00a0VI in stenosed coronary vessels","volume":"119","author":"Al\u2010Tamimi","year":"2012","journal-title":"Blood"},{"key":"10.1111\/jth.12009_bb0145","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1373\/clinchem.2010.158527","article-title":"Sandwich immunoassay for soluble glycoprotein\u00a0VI in patients with symptomatic coronary artery disease","volume":"57","author":"Bigalke","year":"2011","journal-title":"Clin Chem"},{"key":"10.1111\/jth.12009_bb0150","doi-asserted-by":"crossref","first-page":"3912","DOI":"10.1182\/blood-2010-08-301523","article-title":"Coagulation\u2010induced shedding of platelet glycoprotein\u00a0VI mediated by factor\u00a0Xa","volume":"117","author":"Al\u2010Tamimi","year":"2011","journal-title":"Blood"},{"key":"10.1111\/jth.12009_bb0155","doi-asserted-by":"crossref","first-page":"21561","DOI":"10.1074\/jbc.M201012200","article-title":"Association of Fyn and Lyn with the proline\u2010rich domain of glycoprotein\u00a0VI regulates intracellular signaling","volume":"277","author":"Suzuki\u2010Inoue","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.12009_bb0160","doi-asserted-by":"crossref","first-page":"21167","DOI":"10.1073\/pnas.0906436106","article-title":"Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role","volume":"106","author":"Schmaier","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/jth.12009_bb0165","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1111\/j.1538-7836.2005.01429.x","article-title":"GPVI and integrin alphaIIb beta3 signaling in platelets","volume":"3","author":"Watson","year":"2005","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.12009_bb0170","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1161\/ATVBAHA.111.239194","article-title":"Rap1\u2013Rac1 circuits potentiate platelet activation","volume":"32","author":"Stefanini","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1111\/jth.12009_bb0175","doi-asserted-by":"crossref","first-page":"53955","DOI":"10.1074\/jbc.M410355200","article-title":"Vav1 and vav3 have critical but redundant roles in mediating platelet activation by collagen","volume":"279","author":"Pearce","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.12009_bb0180","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1074\/jbc.M606479200","article-title":"Structural basis for the platelet\u2013collagen interaction: the smallest motif within collagen that recognizes and activates platelet glycoprotein\u00a0VI contains two glycine\u2010proline\u2010hydroxyproline triplets","volume":"282","author":"Smethurst","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.12009_bb0185","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1093\/emboj\/20.9.2120","article-title":"Glycoprotein\u00a0VI but not alpha2beta1 integrin is essential for platelet interaction with collagen","volume":"20","author":"Nieswandt","year":"2001","journal-title":"EMBO J"},{"key":"10.1111\/jth.12009_bb0190","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1182\/blood-2003-03-0717","article-title":"The contribution of glycoprotein\u00a0VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletion","volume":"102","author":"Kato","year":"2003","journal-title":"Blood"},{"key":"10.1111\/jth.12009_bb0195","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1111\/j.1538-7836.2003.00495.x","article-title":"Human platelet glycoprotein\u00a0VI function is antagonized by monoclonal antibody\u2010derived Fab fragments","volume":"1","author":"Lecut","year":"2003","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.12009_bb0200","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1182\/blood-2003-03-0889","article-title":"Platelet receptor interplay regulates collagen\u2010induced thrombus formation in flowing human blood","volume":"103","author":"Siljander","year":"2004","journal-title":"Blood"},{"key":"10.1111\/jth.12009_bb0205","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1182\/blood-2008-12-193490","article-title":"Distinct spatio\u2010temporal Ca2+ signaling elicited by integrin alpha2beta1 and glycoprotein\u00a0VI under flow","volume":"114","author":"Mazzucato","year":"2009","journal-title":"Blood"},{"key":"10.1111\/jth.12009_bb0210","doi-asserted-by":"crossref","first-page":"5069","DOI":"10.1182\/blood-2010-01-260778","article-title":"Synergism between platelet collagen receptors defined using receptor\u2010specific collagen\u2010mimetic peptide substrata in flowing blood","volume":"115","author":"Pugh","year":"2010","journal-title":"Blood"},{"key":"10.1111\/jth.12009_bb0215","doi-asserted-by":"crossref","first-page":"3829","DOI":"10.1182\/blood.V97.12.3829","article-title":"Evidence for cross\u2010talk between glycoprotein\u00a0VI and Gi\u2010coupled receptors during collagen\u2010induced platelet aggregation","volume":"97","author":"Nieswandt","year":"2001","journal-title":"Blood"},{"key":"10.1111\/jth.12009_bb0220","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/j.1432-1033.1982.tb05898.x","article-title":"Generation of prothrombin\u2010converting activity and the exposure of phosphatidylserine at the outer surface of platelets","volume":"122","author":"Bevers","year":"1982","journal-title":"Eur J Biochem"},{"key":"10.1111\/jth.12009_bb0225","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.tcm.2005.03.003","article-title":"Platelet collagen receptors and coagulation. A characteristic platelet response as possible target for antithrombotic treatment","volume":"15","author":"Heemskerk","year":"2005","journal-title":"Trends Cardiovasc Med"},{"key":"10.1111\/jth.12009_bb0230","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1182\/blood-2005-06-2406","article-title":"Laminin stimulates spreading of platelets through integrin alpha6beta1\u2010dependent activation of GPVI","volume":"107","author":"Inoue","year":"2006","journal-title":"Blood"},{"key":"10.1111\/jth.12009_bb0235","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.yjmcc.2010.04.009","article-title":"Impact of glycoprotein\u00a0VI and platelet adhesion on atherosclerosis \u2013 a possible role of fibronectin","volume":"49","author":"Bultmann","year":"2010","journal-title":"J Mol Cell Cardiol"},{"key":"10.1111\/jth.12009_bb0240","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1365-2141.2007.06799.x","article-title":"Platelet glycoprotein\u00a0VI\u2010related clinical defects","volume":"139","author":"Arthur","year":"2007","journal-title":"Br J Haematol"},{"key":"10.1111\/jth.12009_bb0245","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1002\/ajh.1128","article-title":"Antibody against platelet membrane glycoprotein\u00a0VI in a patient with systemic lupus erythematosus","volume":"67","author":"Takahashi","year":"2001","journal-title":"Am J Hematol"},{"key":"10.1111\/jth.12009_bb0250","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1182\/blood-2004-03-0896","article-title":"Anti\u2010GPVI\u2010associated ITP: an acquired platelet disorder caused by autoantibody\u2010mediated clearance of the GPVI\/FcRgamma\u2010chain complex from the human platelet surface","volume":"104","author":"Boylan","year":"2004","journal-title":"Blood"},{"key":"10.1111\/jth.12009_bb0255","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1111\/j.1538-7836.2009.03537.x","article-title":"An acquired inhibitor to the GPVI platelet collagen receptor in a patient with lupus nephritis","volume":"7","author":"Nurden","year":"2009","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.12009_bb0260","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1172\/JCI114318","article-title":"A patient with platelets deficient in glycoprotein\u00a0VI that lack both collagen\u2010induced aggregation and adhesion","volume":"84","author":"Moroi","year":"1989","journal-title":"J Clin Invest"},{"key":"10.1111\/jth.12009_bb0265","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/ajh.2830390107","article-title":"Deficiency of P62, a putative collagen receptor, in platelets from a patient with defective collagen\u2010induced platelet aggregation","volume":"39","author":"Ryo","year":"1992","journal-title":"Am J Hematol"},{"key":"10.1111\/jth.12009_bb0270","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1182\/blood-2009-03-213504","article-title":"Absence of collagen\u2010induced platelet activation caused by compound heterozygous GPVI mutations","volume":"114","author":"Dumont","year":"2009","journal-title":"Blood"},{"key":"10.1111\/jth.12009_bb0275","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1111\/j.1538-7836.2009.03520.x","article-title":"A compound heterozygous mutation in glycoprotein\u00a0VI in a patient with a bleeding disorder","volume":"7","author":"Hermans","year":"2009","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.12009_bb0280","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.thromres.2005.08.001","article-title":"GPVI\u2010deficient mice lack collagen responses and are protected against experimentally induced pulmonary thromboembolism","volume":"118","author":"Lockyer","year":"2006","journal-title":"Thromb Res"},{"key":"10.1111\/jth.12009_bb0285","doi-asserted-by":"crossref","first-page":"23998","DOI":"10.1074\/jbc.M003803200","article-title":"Expression and function of the mouse collagen receptor glycoprotein\u00a0VI is strictly dependent on its association with the FcRgamma chain","volume":"275","author":"Nieswandt","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.12009_bb0290","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1084\/jem.193.4.459","article-title":"Long\u2010term antithrombotic protection by in\u00a0vivo depletion of platelet glycoprotein\u00a0VI in mice","volume":"193","author":"Nieswandt","year":"2001","journal-title":"J Exp Med"},{"key":"10.1111\/jth.12009_bb0295","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1182\/blood-2007-09-111369","article-title":"The modifier of hemostasis (Mh) locus on chromosome\u00a04 controls in\u00a0vivo hemostasis of Gp6\u2212\/\u2212 mice","volume":"111","author":"Cheli","year":"2008","journal-title":"Blood"},{"key":"10.1111\/jth.12009_bb0300","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1111\/j.1538-7836.2006.02086.x","article-title":"Distinct antithrombotic consequences of platelet glycoprotein Ibalpha and VI deficiency in a mouse model of arterial thrombosis","volume":"4","author":"Konstantinides","year":"2006","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.12009_bb0305","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1161\/hc0802.105256","article-title":"Platelets activated by collagen through immunoreceptor tyrosine\u2010based activation motif play pivotal role in initiation and generation of neointimal hyperplasia after vascular injury","volume":"105","author":"Konishi","year":"2002","journal-title":"Circulation"},{"key":"10.1111\/jth.12009_bb0310","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1084\/jem.20020945","article-title":"A crucial role of glycoprotein\u00a0VI for platelet recruitment to the injured arterial wall in\u00a0vivo","volume":"197","author":"Massberg","year":"2003","journal-title":"J Exp Med"},{"key":"10.1111\/jth.12009_bb0315","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1111\/j.1538-7836.2011.04328.x","article-title":"Genetic and antibody\u2010induced glycoprotein\u00a0VI deficiency equally protects mice from mechanically and FeCl(3)\u2010induced thrombosis","volume":"9","author":"Bender","year":"2011","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.12009_bb0320","doi-asserted-by":"crossref","first-page":"4346","DOI":"10.1182\/blood-2005-10-4244","article-title":"Thrombin overcomes the thrombosis defect associated with platelet GPVI\/FcRgamma deficiency","volume":"107","author":"Mangin","year":"2006","journal-title":"Blood"},{"key":"10.1111\/jth.12009_bb0325","doi-asserted-by":"crossref","first-page":"3902","DOI":"10.1182\/blood-2005-09-3687","article-title":"Glycoprotein\u00a0VI\u2010dependent and \u2010independent pathways of thrombus formation in\u00a0vivo","volume":"107","author":"Dubois","year":"2006","journal-title":"Blood"},{"key":"10.1111\/jth.12009_bb0330","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1111\/j.1538-7836.2011.04218.x","article-title":"Mechanisms underlying FeCl(3)\u2010induced arterial thrombosis","volume":"9","author":"Eckly","year":"2011","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.12009_bb0335","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.atherosclerosis.2004.12.037","article-title":"Contribution of platelet glycoprotein\u00a0VI to the thrombogenic effect of collagens in fibrous atherosclerotic lesions","volume":"181","author":"Cosemans","year":"2005","journal-title":"Atherosclerosis"},{"key":"10.1111\/jth.12009_bb0340","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.jacc.2009.11.051","article-title":"A 2\u2010step mechanism of arterial thrombus formation induced by human atherosclerotic plaques","volume":"55","author":"Reininger","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1111\/jth.12009_bb0345","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1538-7836.2008.03186.x","article-title":"Complementary roles of platelets and coagulation in thrombus formation on plaques acutely ruptured by targeted ultrasound treatment: a novel intravital model","volume":"7","author":"Kuijpers","year":"2009","journal-title":"J Thromb Haemost"},{"issue":"Suppl. 1","key":"10.1111\/jth.12009_bb0350","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1160\/THS10-11-0730","article-title":"Comparison of two murine models of thrombosis induced by atherosclerotic plaque injury","volume":"105","author":"Hechler","year":"2011","journal-title":"Thromb Haemost"},{"key":"10.1111\/jth.12009_bb0355","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1093\/cvr\/cvn169","article-title":"The immunoadhesin glycoprotein\u00a0VI\u2010Fc regulates arterial remodelling after mechanical injury in ApoE\u2212\/\u2212 mice","volume":"80","author":"Schonberger","year":"2008","journal-title":"Cardiovasc Res"},{"key":"10.1111\/jth.12009_bb0360","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1096\/fj.03-0464fje","article-title":"Soluble glycoprotein\u00a0VI dimer inhibits platelet adhesion and aggregation to the injured vessel wall in\u00a0vivo","volume":"18","author":"Massberg","year":"2004","journal-title":"FASEB J"},{"key":"10.1111\/jth.12009_bb0365","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1182\/blood-2004-06-2391","article-title":"Relative antithrombotic effect of soluble GPVI dimer compared with anti\u2010GPVI antibodies in mice","volume":"105","author":"Gruner","year":"2005","journal-title":"Blood"},{"key":"10.1111\/jth.12009_bb0370","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1160\/TH05-11-0731","article-title":"Local delivery of soluble platelet collagen receptor glycoprotein\u00a0VI inhibits thrombus formation in\u00a0vivo","volume":"95","author":"Bultmann","year":"2006","journal-title":"Thromb Haemost"},{"key":"10.1111\/jth.12009_bb0375","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1161\/CIRCULATIONAHA.110.980623","article-title":"Novel antiplatelet drug revacept (dimeric glycoprotein\u00a0VI\u2010Fc) specifically and efficiently inhibited collagen\u2010induced platelet aggregation without affecting general hemostasis in humans","volume":"123","author":"Ungerer","year":"2011","journal-title":"Circulation"},{"key":"10.1111\/jth.12009_bb0380","doi-asserted-by":"crossref","first-page":"e5585","DOI":"10.1371\/journal.pone.0005585","article-title":"Non\u2010invasive molecular imaging of fibrosis using a collagen\u2010targeted peptidomimetic of the platelet collagen receptor glycoprotein\u00a0VI","volume":"4","author":"Muzard","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1111\/jth.12009_bb0385","first-page":"A10987","article-title":"Discovery of a novel aptamer\u2010based inhibitor of GPVI and its matched active control agent","volume":"122","author":"Rusconi","year":"2010","journal-title":"Circulation"},{"key":"10.1111\/jth.12009_bb0390","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1161\/ATVBAHA.106.138693","article-title":"EXP3179 inhibits collagen\u2010dependent platelet activation via glycoprotein receptor\u2010VI independent of AT1\u2010receptor antagonism: potential impact on atherothrombosis","volume":"27","author":"Grothusen","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1111\/jth.12009_bb0395","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1021\/jm901534d","article-title":"Structural basis for platelet antiaggregation by angiotensin\u00a0II type\u00a01 receptor antagonist losartan (DuP\u2010753) via glycoprotein\u00a0VI","volume":"53","author":"Ono","year":"2010","journal-title":"J Med Chem"},{"key":"10.1111\/jth.12009_bb0400","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1517\/14728222.12.6.677","article-title":"Novel mechanistic concept of platelet inhibition","volume":"12","author":"Sigalov","year":"2008","journal-title":"Expert Opin Ther Targets"},{"key":"10.1111\/jth.12009_bb0405","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1172\/JCI32513","article-title":"A novel antiplatelet antibody therapy that induces cAMP\u2010dependent endocytosis of the GPVI\/Fc receptor gamma\u2010chain complex","volume":"118","author":"Takayama","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1111\/jth.12009_bb0410","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1182\/blood-2005-07-2937","article-title":"Activation\u2010independent, antibody\u2010mediated removal of GPVI from circulating human platelets: development of a novel NOD\/SCID mouse model to evaluate the in\u00a0vivo effectiveness of anti\u2010human platelet agents","volume":"108","author":"Boylan","year":"2006","journal-title":"Blood"},{"key":"10.1111\/jth.12009_bb0415","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1111\/j.1538-7836.2008.03016.x","article-title":"Compromised ITAM\u2010based platelet receptor function in a patient with immune thrombocytopenic purpura","volume":"6","author":"Gardiner","year":"2008","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.12009_bb0420","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1182\/blood-2006-11-058107","article-title":"Diverging signaling events control the pathway of GPVI down\u2010regulation in\u00a0vivo","volume":"110","author":"Rabie","year":"2007","journal-title":"Blood"},{"key":"10.1111\/jth.12009_bb0425","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1182\/blood-2004-07-2842","article-title":"Platelet activation induces metalloproteinase\u2010dependent GP\u00a0VI cleavage to down\u2010regulate platelet reactivity to collagen","volume":"105","author":"Stephens","year":"2005","journal-title":"Blood"},{"key":"10.1111\/jth.12009_bb0430","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1080\/09537100802645029","article-title":"Anti\u2010glycoprotein\u00a0VI monoclonal antibodies directly aggregate platelets independently of FcgammaRIIa and induce GPVI ectodomain shedding","volume":"20","author":"Al\u2010Tamimi","year":"2009","journal-title":"Platelets"},{"key":"10.1111\/jth.12009_bb0435","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3233\/HAB-2002-11306","article-title":"Anti GPVI human antibodies neutralizing collagen\u2010induced platelet aggregation isolated from a combinatorial phage display library","volume":"11","author":"Qian","year":"2002","journal-title":"Hum Antibodies"},{"key":"10.1111\/jth.12009_bb0440","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1080\/09537100902893792","article-title":"Single domain antibodies against the collagen signalling receptor glycoprotein\u00a0VI are inhibitors of collagen induced thrombus formation","volume":"20","author":"Walker","year":"2009","journal-title":"Platelets"},{"key":"10.1111\/jth.12009_bb0445","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1055\/s-0037-1613401","article-title":"A new monoclonal antibody, mAb\u00a0204\u201011, that influences the binding of platelet GPVI to fibrous collagen","volume":"89","author":"Moroi","year":"2003","journal-title":"Thromb Haemost"},{"key":"10.1111\/jth.12009_bb0450","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.thromres.2006.01.023","article-title":"Highly potent anti\u2010human GPVI monoclonal antibodies derived from GPVI knockout mouse immunization","volume":"119","author":"Matsumoto","year":"2007","journal-title":"Thromb Res"},{"key":"10.1111\/jth.12009_bb0455","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1160\/TH06-05-0266","article-title":"Ex\u00a0vivo evaluation of anti\u2010GPVI antibody in cynomolgus monkeys: dissociation between anti\u2010platelet aggregatory effect and bleeding time","volume":"96","author":"Matsumoto","year":"2006","journal-title":"Thromb Haemost"},{"key":"10.1111\/jth.12009_bb0460","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1161\/ATVBAHA.107.140590","article-title":"The Fab fragment of a novel anti\u2010GPVI monoclonal antibody, OM4, reduces in\u00a0vivo thrombosis without bleeding risk in rats","volume":"27","author":"Li","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1111\/jth.12009_bb0465","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1111\/j.1538-7836.2008.02976.x","article-title":"Ex\u00a0vivo inhibition of thrombus formation by an anti\u2010glycoprotein\u00a0VI Fab fragment in non\u2010human primates without modification of glycoprotein\u00a0VI expression","volume":"6","author":"Ohlmann","year":"2008","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.12009_bb0470","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1124\/jpet.111.189050","article-title":"A humanized glycoprotein\u00a0VI (GPVI) mouse model to assess the antithrombotic efficacies of anti\u2010GPVI agents","volume":"341","author":"Mangin","year":"2012","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1111\/jth.12009_bb0475","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1160\/TH04-12-0783","article-title":"Fibrillar type\u00a0I collagens enhance platelet\u2010dependent thrombin generation via glycoprotein\u00a0VI with direct support of alpha2beta1 but not alphaIIbbeta3 integrin","volume":"94","author":"Lecut","year":"2005","journal-title":"Thromb Haemost"},{"key":"10.1111\/jth.12009_bb0480","doi-asserted-by":"crossref","first-page":"4207","DOI":"10.1111\/j.1742-4658.2009.07129.x","article-title":"Design and humanization of a murine scFv that blocks human platelet glycoprotein\u00a0VI in\u00a0vitro","volume":"276","author":"Muzard","year":"2009","journal-title":"FEBS J"},{"key":"10.1111\/jth.12009_bb0485","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1468-1331.2009.02754.x","article-title":"Expression of platelet glycoprotein\u00a0VI is associated with transient ischemic attack and stroke","volume":"17","author":"Bigalke","year":"2010","journal-title":"Eur J Neurol"},{"key":"10.1111\/jth.12009_bb0490","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1161\/STROKEAHA.110.602532","article-title":"Soluble glycoprotein\u00a0VI is raised in the plasma of patients with acute ischemic stroke","volume":"42","author":"Al\u2010Tamimi","year":"2011","journal-title":"Stroke"},{"key":"10.1111\/jth.12009_bb0495","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1016\/S0140-6736(11)60516-3","article-title":"Medical treatment in acute and long\u2010term secondary prevention after transient ischaemic attack and ischaemic stroke","volume":"377","author":"Rothwell","year":"2011","journal-title":"Lancet"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjth.12009","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjth.12009","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622065254?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622065254?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/jth.12009\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T02:57:17Z","timestamp":1761533837000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783622065254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":98,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S1538783622065254"],"URL":"https:\/\/doi.org\/10.1111\/jth.12009","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The future of glycoprotein\u00a0VI as an antithrombotic target","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/jth.12009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 International Society on Thrombosis and Haemostasis. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}