{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:26:38Z","timestamp":1791267998501,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T00:00:00Z","timestamp":1670284800000},"content-version":"vor","delay-in-days":3657,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1111\/jth.12019","type":"journal-article","created":{"date-parts":[[2012,10,5]],"date-time":"2012-10-05T14:01:00Z","timestamp":1349445660000},"page":"2535-2543","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"title":["VKORC1 mutations detected in patients resistant to vitamin K antagonists are not all associated with a resistant VKOR activity"],"prefix":"10.1016","volume":"10","author":[{"given":"A.","family":"HODROGE","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"MATAGRIN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"MOREAU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"FOUREL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"HAMMED","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"BENOIT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"LATTARD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/jth.12019_bb0010","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1001\/archinte.167.13.1414","article-title":"Bleeding complications with warfarin use: a prevalent adverse effect resulting in regulatory action","volume":"167","author":"Wysowski","year":"2007","journal-title":"Arch Intern Med"},{"key":"10.1111\/jth.12019_bb0015","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1056\/NEJMoa044503","article-title":"Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose","volume":"352","author":"Rieder","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1111\/jth.12019_bb0020","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1182\/blood-2004-06-2111","article-title":"A polymorphism in the VKORC1 gene is associated with an interindividual variability in the dose\u2010anticooagulant effect of warfarin","volume":"105","author":"D\u2019Andrea","year":"2005","journal-title":"Blood"},{"key":"10.1111\/jth.12019_bb0025","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1111\/j.1538-7836.2005.01449.x","article-title":"A vitamin K epoxide reductase complex subunit\u20101 (VKORC1) mutation in a patient with vitamin K antagonist resistance","volume":"3","author":"Bodin","year":"2005","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.12019_bb0030","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1097\/01.fpc.0000174789.77614.68","article-title":"Association of vitamin K epoxide reductase complex 1 (VKORC1) variants with warfarin dose in Hong Kong chinese patient population","volume":"15","author":"Veenstra","year":"2005","journal-title":"Pharmacogenet Genomics"},{"key":"10.1111\/jth.12019_bb0035","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1160\/TH04-12-0773","article-title":"Patients with unstable control have a poorer dietary intake of vitamin K compared to patients with stable control of anticoagulation","volume":"93","author":"Sconce","year":"2005","journal-title":"Thromb Haemost"},{"key":"10.1111\/jth.12019_bb0040","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.2217\/pgs.09.125","article-title":"Genotype\u2010guided dosing of coumarin derivatives: the European pharmacogenetics of anticoagulant therapy (EU\u2010PACT) trial design","volume":"10","author":"van Schie","year":"2009","journal-title":"Pharmacogenomics."},{"key":"10.1111\/jth.12019_bb0045","author":"Epstein","year":"2010","journal-title":"Atlanta"},{"key":"10.1111\/jth.12019_bb0050","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nature02254","article-title":"Identification for the gene for vitamin K epoxide reductase","volume":"427","author":"Li","year":"2004","journal-title":"Nature"},{"key":"10.1111\/jth.12019_bb0055","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/nature02214","article-title":"Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2","volume":"427","author":"Rost","year":"2004","journal-title":"Nature"},{"key":"10.1111\/jth.12019_bb0060","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/jbt.20104","article-title":"Warfarin resistance in a French strain of rats","volume":"19","author":"Lasseur","year":"2005","journal-title":"J Biochem Mol Toxicol"},{"key":"10.1111\/jth.12019_bb0065","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0083-6729(07)00003-9","article-title":"The vitamin K cycle","volume":"78","author":"Oldenburg","year":"2008","journal-title":"Vitam Horm"},{"key":"10.1111\/jth.12019_bb0070","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/nature08720","article-title":"Structure of a bacterial homologue of vitamin K epoxide","volume":"463","author":"Li","year":"2010","journal-title":"Nature"},{"key":"10.1111\/jth.12019_bb0075","doi-asserted-by":"crossref","first-page":"7279","DOI":"10.1021\/bi700527j","article-title":"The conversion of vitamin K epoxide to vitamin K quinone and vitamin K quinone to vitamin K hydroquinone uses the same active site cysteines","volume":"46","author":"Jin","year":"2007","journal-title":"Biochemistry"},{"key":"10.1111\/jth.12019_bb0080","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.tibs.2004.04.004","article-title":"Vitamin K epoxide reductase: homology, active site and catalytic mechanism","volume":"29","author":"Goodstadt","year":"2004","journal-title":"Trends Biochem Sci"},{"key":"10.1111\/jth.12019_bb0085","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1534\/genetics.104.040360","article-title":"The genetic basis of resistance to anticoagulants in rodents","volume":"170","author":"Pelz","year":"2005","journal-title":"Genetics"},{"key":"10.1111\/jth.12019_bb0090","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1021\/ja01867a066","article-title":"Hydro, oxydo and other derivatives of vitamin K1 related compounds","volume":"62","author":"Tishler","year":"1940","journal-title":"J Am Chem Soc"},{"key":"10.1111\/jth.12019_bb0095","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.abb.2011.08.010","article-title":"Biochemical characterization of spontaneous mutants of rat VKORC1 involved in the resistance to antivitamin K","volume":"515","author":"Hodroge","year":"2011","journal-title":"Arch Biochem Biophys"},{"key":"10.1111\/jth.12019_bb0100","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1080\/10618600.1996.10474713","article-title":"A language for data analysis and graphics","volume":"5","author":"Ihaka","year":"1996","journal-title":"J Comput Graph Stat."},{"key":"10.1111\/jth.12019_bb0105","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1097\/FPC.0b013e32832ee55b","article-title":"Consequences of the Y139F Vkorc1 mutation on resistance to AVKs: in vivo investigation in a 7th generation of congenic Y139F strain of rats","volume":"19","author":"Grandemange","year":"2009","journal-title":"Pharmacogenet Genomics"},{"key":"10.1111\/jth.12019_bb0110","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1111\/j.1538-7836.2008.03049.x","article-title":"Multiple genetic alterations in vitamin K epoxide reductase complex subunit 1 gene (VKORC1) can explain the high dose requirement during oral anticoagulation in humans","volume":"6","author":"Bodin","year":"2008","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.12019_bb0115","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1111\/j.1538-7836.2008.03116.x","article-title":"Pharmacodynamic resistance to warfarin is associated with nucleotide substitutions in VKORC1","volume":"6","author":"Harrington","year":"2008","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.12019_bb0120","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1538-7836.2010.04095.x","article-title":"Thirteen novel VKORC1 mutations associated with oral anticoagulant resistance: insights into improved patient diagnosis and treatment","volume":"9","author":"Watzka","year":"2011","journal-title":"J Throm Haemost."},{"key":"10.1111\/jth.12019_bb0125","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1111\/j.1538-7836.2006.02039.x","article-title":"Main haplotypes and mutational analysis of vitamin K epoxide reductase (VKORC1) in a Swedish population: a retrospective analysis of case records","volume":"4","author":"Osman","year":"2006","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.12019_bb0130","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1089\/ars.2006.8.347","article-title":"Vitamin K epoxide reductase complex subunit 1 (VKORC1): the key protein of the vitamin K cycle","volume":"8","author":"Oldenburg","year":"2006","journal-title":"Antioxid Redox Signal"},{"key":"10.1111\/jth.12019_bb0135","first-page":"10","article-title":"Novel mutations in the VKORC1 gene of wild rats and mice\u2010a response to 50\u2003years of selection pressure by warfarin","volume":"6","author":"Rost","year":"2009","journal-title":"BMC Genet"},{"key":"10.1111\/jth.12019_bb0140","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1096\/fj.01-0337fje","article-title":"A molecular mechanism for genetic warfarin in the rat","volume":"15","author":"Wallin","year":"2001","journal-title":"FASEB J."},{"key":"10.1111\/jth.12019_bb0145","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1111\/j.1538-7836.2011.04249.x","article-title":"More on: endoplasmic reticulum loop VKORC1 substitutions cause warfarin resistance but do not diminish gamma\u2010carboxylation of the vitamin K\u2010dependent coagulation factors","volume":"9","author":"Harrington","year":"2011","journal-title":"J Thromb Haemost"},{"key":"10.1111\/jth.12019_bb0150","doi-asserted-by":"crossref","first-page":"7267","DOI":"10.1074\/jbc.M110.172213","article-title":"Novel insight into the mechanism of the vitamin K oxidoreductase (VKOR): electron relay through Cys43 and Cys51 reduces VKOR to allow vitamin K reduction and facilitation of vitamin K\u2010dependent protein carboxylation","volume":"286","author":"Rishavy","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1111\/jth.12019_bb0155","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1160\/TH05-02-0082","article-title":"Site\u2010directed mutagenesis of coumarin\u2010type anticoagulant\u2010sensitive VKORC1: evidence that highly conserved amino acids define structural requirements for enzymatic activity and inhibition by warfarin","volume":"94","author":"Rost","year":"2005","journal-title":"Thromb Haemost"},{"key":"10.1111\/jth.12019_bb0160","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1111\/j.1365-2141.2009.07687.x","article-title":"A new VKORC1 mutation leading to an isolated resistance to fluindione","volume":"145","author":"Peoc\u2019h","year":"2009","journal-title":"Br J Haematol"},{"key":"10.1111\/jth.12019_bb0165","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1182\/blood-2006-08-038984","article-title":"A coding VKORC1 Asp36Tyr polymorphism predisposes to warfarin resistance","volume":"109","author":"Loebstein","year":"2007","journal-title":"Blood"},{"key":"10.1111\/jth.12019_bb0170","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1111\/j.1365-2141.2009.08017.x","article-title":"VKORC1 mutations in patients with partial resistance to phenprocoumon","volume":"148","author":"Schmeits","year":"2010","journal-title":"Br J Haematol"},{"key":"10.1111\/jth.12019_bb0175","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1111\/j.1538-7836.2008.02975.x","article-title":"A new VKORC1 allelic variant (p. Trp59Arg) in a patient with partial resistance to acenocoumarol and phenprocoumon","volume":"6","author":"Wilms","year":"2008","journal-title":"J Thromb Haemost"}],"container-title":["Journal of Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjth.12019","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjth.12019","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622065357?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1538783622065357?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/jth.12019\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T02:56:59Z","timestamp":1761533819000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1538783622065357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":34,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S1538783622065357"],"URL":"https:\/\/doi.org\/10.1111\/jth.12019","relation":{},"ISSN":["1538-7836"],"issn-type":[{"value":"1538-7836","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"VKORC1 mutations detected in patients resistant to vitamin K antagonists are not all associated with a resistant VKOR activity","name":"articletitle","label":"Article Title"},{"value":"Journal of Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/jth.12019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 International Society on Thrombosis and Haemostasis. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}